METHYL 3-OXOCYCLOBUTANECARBOXYLATE
- Product Name
- METHYL 3-OXOCYCLOBUTANECARBOXYLATE
- CAS No.
- 695-95-4
- Chemical Name
- METHYL 3-OXOCYCLOBUTANECARBOXYLATE
- Synonyms
- methyl 3-oxocyclobutane-1-carboxylate;Methyl oxetane-3-carboxylate;Carboplatin 10;Methyl 3-oxo-cyclobutanec...;3-methoxycarbonylcyclobutanone;METHYL 3-OXOCYCLOBUTANECARBOXYLATE;Methyl 3-oxocyclobutan-1-carboxylate;3-Oxo-cyclobutanecarboxylic acid methyl ester;Cyclobutanecarboxylic acid, 3-oxo-, Methyl ester
- CBNumber
- CB8823171
- Molecular Formula
- C6H8O3
- Formula Weight
- 128.13
- MOL File
- 695-95-4.mol
METHYL 3-OXOCYCLOBUTANECARBOXYLATE Property
- Boiling point:
- 188.0±33.0 °C(Predicted)
- Density
- 1.219g/ml
- storage temp.
- 2-8°C
- form
- liquid
- color
- Colourless
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H8O3/c1-9-6(8)4-2-5(7)3-4/h4H,2-3H2,1H3
- InChIKey
- IHLHSAIBOSSHQV-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)CC(=O)C1
Safety
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- O870105
- Product name
- 3-OxocyclobutanecarboxylicAcidMethylEster
- Packaging
- 500mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 160708
- Product name
- 3-Oxocyclobutanecarboxylic Acid Methyl Ester
- Packaging
- 250mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- J90272
- Product name
- Methyl3-oxocyclobutanecarboxylate
- Packaging
- 5g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 068561
- Product name
- Methyl 3-oxocyclobutanecarboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 068561
- Product name
- Methyl 3-oxocyclobutanecarboxylate
- Purity
- >95%
- Packaging
- 25g
- Price
- $69
- Updated
- 2021/12/16
METHYL 3-OXOCYCLOBUTANECARBOXYLATE Chemical Properties,Usage,Production
Uses
Methyl 3-oxocyclobutanecarboxylate can be used as an intermediate for the synthesis of various pharmaceutical compounds. It is used for the preparation of novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders.
Synthesis
67-56-1
23761-23-1
695-95-4
Concentrated sulfuric acid (0.2 mL) was slowly added dropwise to a solution of 3-oxocyclobutanecarboxylic acid (1 g, 8.77 mmol) in methanol (appropriate amount), followed by heating and refluxing the reaction mixture at 75 °C. The reaction progress was monitored by thin layer chromatography (TLC) and after complete conversion of the feedstock, saturated sodium bicarbonate solution was added to the reaction solution to quench the reaction. The solvent methanol was removed by distillation under reduced pressure and the resulting residue was separated by extraction with ethyl acetate and water. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl 3-oxocyclobutanecarboxylate (1.1 g, 99% yield) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 3.22-3.34 (m, 3H), 3.40-3.47 (m, 2H), 3.78 (s, 3H).
References
[1] Patent: EP3235819, 2017, A1. Location in patent: Paragraph 0213; 0214
[2] Patent: WO2011/6621, 2011, A1. Location in patent: Page/Page column 36
[3] Patent: WO2017/48675, 2017, A1. Location in patent: Paragraph 0479
[4] Patent: CN104402754, 2016, B. Location in patent: Paragraph 0187; 0188
[5] Patent: CN104447583, 2016, B. Location in patent: Paragraph 0135; 0136; 0137; 0138; 0139
METHYL 3-OXOCYCLOBUTANECARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL 3-OXOCYCLOBUTANECARBOXYLATE manufacturers
- Product
- Methyl 3-oxocyclobutanecarboxylate 695-95-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Methyl 3-oxocyclobutanecarboxylate 695-95-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- METHYL 3-OXOCYCLOBUTANECARBOXYLATE 695-95-4
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05