3-HYDROXYCYCLOBUTANECARBOXYLIC ACID
Uses- Product Name
- 3-HYDROXYCYCLOBUTANECARBOXYLIC ACID
- CAS No.
- 194788-10-8
- Chemical Name
- 3-HYDROXYCYCLOBUTANECARBOXYLIC ACID
- Synonyms
- 3-HydroxycycL;Cyclobutanecarboxylic acid, 3-hydroxy-;3-Hydroxycyclobutanecarboxylic Acid(WX610009);3-Hydroxycyclobutanecarboxylic acid - [H12369];3-Hydroxycyclobutanecarboxylic Acid (mixture of cis- and trans-)
- CBNumber
- CB5794311
- Molecular Formula
- C5H8O3
- Formula Weight
- 116.12
- MOL File
- 194788-10-8.mol
3-HYDROXYCYCLOBUTANECARBOXYLIC ACID Property
- Boiling point:
- 290.1±33.0 °C(Predicted)
- Density
- 1.45g/ml
- storage temp.
- 2-8°C
- pka
- 4.54±0.40(Predicted)
- form
- solid
- color
- White
- InChI
- InChI=1S/C5H8O3/c6-4-1-3(2-4)5(7)8/h3-4,6H,1-2H2,(H,7,8)
- InChIKey
- ZSHGVMYLGGANKU-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)CC(O)C1
Safety
- RIDADR
- UN2811
- HS Code
- 2918199890
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H950128
- Product name
- 3-HydroxycyclobutanecarboxylicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR308101
- Product name
- 3-Hydroxycyclobutanecarboxylicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $486
- Updated
- 2021/12/16
- Product number
- 113910
- Product name
- 3-Hydroxycyclobutanecarboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $529
- Updated
- 2021/12/16
- Product number
- W4156
- Product name
- 3-Hydroxycyclobutanecarboxylicacid
- Packaging
- 100mg
- Price
- $91
- Updated
- 2021/12/16
- Product number
- W4156
- Product name
- 3-Hydroxycyclobutanecarboxylicacid
- Packaging
- 1g
- Price
- $142
- Updated
- 2021/12/16
3-HYDROXYCYCLOBUTANECARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
3-Hydroxycyclobutylcarboxylic acid and its derivatives are important pharmaceutical intermediates widely used in drug synthesis. For example, they are used to synthesize the clinically widely used anti-inflammatory and analgesic loxoprofen sodium, the bactericide tebuconazole, and the side chain of the broad-spectrum antibacterial drug cefpirome. 3-Hydroxycyclobutylcarboxylic acid is mainly used in the preparation of antiviral and antitumor drugs, and also has wide applications in the design and development of novel functional polymers, specialty surfactants, and high-performance lubricants.
Synthesis
4934-99-0
194788-10-8
General procedure for the synthesis of 3-hydroxycyclobutanecarboxylic acid from methyl 3-hydroxycyclobutanecarboxylate: cis-3-hydroxycyclobutanecarboxylic acid methyl ester (273.3 g, 2.1 mol, 1 eq.) was dissolved in a mixed solvent of H2O/THF (1 L/1.5 L), followed by addition of lithium hydroxide monohydrate (218.2 g, 5.2 mol, 2.5 eq.). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, THF was removed by distillation under reduced pressure. the pH of the reaction solution was adjusted to 4~5 with dilute hydrochloric acid, and then extracted with a chloroform/isopropanol solvent mixture in the ratio of 4:1 by volume. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by ethyl acetate/n-heptane mixed solvent pulping to afford 3-hydroxycyclobutanecarboxylic acid (197.4 g, 1.7 mol) in off-white solid form with 81% yield and 97% purity.
References
[1] Patent: CN107903161, 2018, A. Location in patent: Paragraph 0033; 0034
3-HYDROXYCYCLOBUTANECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-HYDROXYCYCLOBUTANECARBOXYLIC ACID manufacturers
- Product
- 3-HYDROXYCYCLOBUTANECARBOXYLIC ACID 194788-10-8
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-02