3-Hydroxy-cyclobutanecarboxylic acid ethyl ester
- Product Name
- 3-Hydroxy-cyclobutanecarboxylic acid ethyl ester
- CAS No.
- 17205-02-6
- Chemical Name
- 3-Hydroxy-cyclobutanecarboxylic acid ethyl ester
- Synonyms
- Ethyl 3-hydroxycyclobutan...;ethyl 3-hydroxycyclobutane-1-carboxylate;Ethyl 3-hydroxycyclobutane-1-carboxylate 95%;3-Hydroxy-cyclobutanecarboxylic acid ethyl ester;Cyclobutanecarboxylic acid, 3-hydroxy-, ethyl ester
- CBNumber
- CB61856435
- Molecular Formula
- C7H12O3
- Formula Weight
- 144.17
- MOL File
- 17205-02-6.mol
3-Hydroxy-cyclobutanecarboxylic acid ethyl ester Property
- Boiling point:
- 209℃
- Density
- 1.180
- refractive index
- 1.4504
- Flash point:
- 83℃
- storage temp.
- Inert atmosphere,Room Temperature
- form
- liquid
- color
- Clear Colourless
- InChI
- InChI=1S/C7H12O3/c1-2-10-7(9)5-3-6(8)4-5/h5-6,8H,2-4H2,1H3
- InChIKey
- KTVUZBJHOAPDGC-UHFFFAOYSA-N
- SMILES
- C1(C(OCC)=O)CC(O)C1
Safety
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H336May cause drowsiness or dizziness
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E945595
- Product name
- Ethyl3-Hydroxycyclobutanecarboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E945595
- Product name
- Ethyl3-Hydroxycyclobutanecarboxylate
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR308100
- Product name
- Ethyl3-hydroxycyclobutane-1-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 2229-1-29
- Product name
- Ethyl 3-hydroxycyclobutanecarboxylate
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- Y6088
- Product name
- Ethyl3-hydroxycyclobutanecarboxylate
- Packaging
- 5g
- Price
- $211
- Updated
- 2021/12/16
3-Hydroxy-cyclobutanecarboxylic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
87121-89-9
17205-02-6
General procedure for the synthesis of ethyl 3-hydroxycyclobutanecarboxylate from ethyl 3-oxocyclobutanecarboxylate: to a solution of ethyl 3-oxocyclobutanecarboxylate (0.18 g, 1.27 mmol) in methanol (10 mL) was slowly added sodium borohydride (0.048 g, 1.27 mmol) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 30 min, followed by quenching the reaction with aqueous 1N hydrochloric acid. Volatile solvents were removed by distillation under reduced pressure and the residue was extracted by partitioning with ethyl acetate and 1N aqueous hydrochloric acid. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the target product ethyl 3-hydroxycyclobutanecarboxylate (0.17 g, 93% yield) as a mixture of cis and trans isomers. The product was characterized by 1H NMR (500 MHz, CDCl3), δ 4.17-4.24 (m, 1H), 4.15 (d, J=7.2 Hz, 2H), 2.54-2.66 (m, 3H), 2.11-2.22 (m, 2H), 1.27 (t, J=7.2 Hz, 3H).
References
[1] Patent: WO2016/40223, 2016, A1. Location in patent: Paragraph 00218
[2] Patent: WO2018/162607, 2018, A1. Location in patent: Paragraph 0769; 0770
[3] Patent: WO2016/24185, 2016, A1. Location in patent: Page/Page column 127
[4] Patent: US5681858, 1997, A
[5] Patent: WO2011/106273, 2011, A1. Location in patent: Page/Page column 72
3-Hydroxy-cyclobutanecarboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Hydroxy-cyclobutanecarboxylic acid ethyl ester manufacturers
- Product
- Ethyl 3-hydroxycyclobutanecarboxylate 17205-02-6
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 3-Hydroxy-cyclobutanecarboxylic acid ethyl ester 17205-02-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26