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3-Oxocyclobutanecarboxylic acid

Product Name
3-Oxocyclobutanecarboxylic acid
CAS No.
23761-23-1
Chemical Name
3-Oxocyclobutanecarboxylic acid
Synonyms
3-oxocyclobutane-1-carboxylic acid;3-OXO-CYCLOBUTANECARBOXYLIC ACID;3-oxocyclobutane-1,1-dicarboxylic acid;3-OxocycL;IFLAB-BB F2124-0041;1-Carboxy-3-oxocyclobutane;3-Oxocyclobutanecarboxylic;3-Oxocyclobutanecarboxyli...;Oxocyclobutanecarboxylic acid;3-Oxycyclobutanecarboxylic acid
CBNumber
CB0111483
Molecular Formula
C5H6O3
Formula Weight
114.1
MOL File
23761-23-1.mol
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3-Oxocyclobutanecarboxylic acid Property

Melting point:
69-70℃
Boiling point:
296°C
Density 
1.431
Flash point:
147°C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Solid
pka
4.35±0.20(Predicted)
color 
Off-white
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C5H6O3/c6-4-1-3(2-4)5(7)8/h3H,1-2H2,(H,7,8)
InChIKey
IENOFRJPUPTEMI-UHFFFAOYSA-N
SMILES
C1(C(O)=O)CC(=O)C1
CAS DataBase Reference
23761-23-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
26-37-60
TSCA 
No
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS004694
Product name
3-Oxocyclobutanecarboxylic acid
Purity
AldrichCPR
Packaging
100mg
Price
$70.9
Updated
2024/03/01
TCI Chemical
Product number
O0392
Product name
3-Oxocyclobutanecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
O0392
Product name
3-Oxocyclobutanecarboxylic Acid
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$52
Updated
2024/03/01
Alfa Aesar
Product number
H64774
Product name
3-Oxocyclobutanecarboxylic acid, 98%
Packaging
5g
Price
$51.65
Updated
2024/03/01
Alfa Aesar
Product number
H64774
Product name
3-Oxocyclobutanecarboxylic acid, 98%
Packaging
25g
Price
$207.65
Updated
2024/03/01
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3-Oxocyclobutanecarboxylic acid Chemical Properties,Usage,Production

Description

3-Oxocyclobutanecarboxylic acid is an organic common intermediate compound used in pharmaceuticals, organic synthesis and organic light-emitting diode (OLED) intermediates. Abrocitinib, prepared from 3-Oxocyclobutanecarboxylic acid, is approved for the treatment of adult patients with atopic dermatitis (AD), as well as patients with refractory moderate to severe AD who have had limited or minimal response to other systemic medications.

Chemical Properties

White solid

Uses

3-Oxocyclobutanecarboxylic Acid (cas# 23761-23-1) is a compound useful in organic synthesis.

Application

3-Oxocyclobutanecarboxylic acid is a very important medicine intermediate, it is widely applied in the synthetic of tens kinds of bulk drugs, such as ACK1 antibody, the MDM2 antagonist, the JAK inhibitor, CETP inhibitor, kinase inhibitor, the PDE10 inhibitor, thrombin inhibitors and in autoimmunization chronic inflammatory diseases and antitumor drug, all being used to.

Preparation

The target product 3-oxocyclobutanecarboxylic acid is obtained by adopting acetone, bromine, and malononitrile as raw materials, adopting ethanol, DMF (dimethyl formamide), and water as solvents, adopting sodium iodide as an activating agent and tetrabutylammonium bromide (TBAB) as a phase transfer catalyst through three-step reaction.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 3841, 1988 DOI: 10.1021/jo00251a033

3-Oxocyclobutanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Oxocyclobutanecarboxylic acid Suppliers

BTC Pharmaceutical CO. Ltd
Tel
0513-68015397; 15716293042
Fax
0513-68015394
Email
sales12@btcpharm.com
Country
China
ProdList
686
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55
Mashilabs (Shanghai) Co.,Ltd.
Tel
19916721580
Fax
QQ:3154870176
Email
mafarm@126.com
Country
China
ProdList
4308
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58
Chongqing Acemol Technology Co.,Ltd
Tel
023-86822659,企业QQ3004125759 18611316925
Email
sales@acemol.com
Country
China
ProdList
995
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55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
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50
Z IntellecChem& Tech. Co., Ltd
Tel
15050866711
Fax
QQ:2677337387
Email
saleszchem@163.com
Country
China
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Nanjing Vcare PharmaTech Co., Ltd
Tel
025-58741518 17366379912
Email
sales@vcarepharmatech.com
Country
China
ProdList
505
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58
Beijing Whale Technology Corporation Ltd.
Tel
010-83694934 13671295325
Email
sales@whalecorporation.com
Country
China
ProdList
128
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58
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
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55
Lianhe Aigen Pharmatech Co.,Ltd.
Tel
18918657159
Email
sales-Aigen@lianhetech.com
Country
China
ProdList
2992
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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76
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View Lastest Price from 3-Oxocyclobutanecarboxylic acid manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
3-Oxocyclobutanecarboxylic acid 23761-23-1
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-15
Hebei Dangtong Import and export Co LTD
Product
3-Oxocyclobutanecarboxylic acid 23761-23-1
Price
US $874.00-862.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
100Tons
Release date
2023-03-02
airuikechemical co., ltd.
Product
3-Oxocyclobutane carboxylic acid 23761-23-1
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08

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