3-Oxocyclobutanecarboxylic acid

Product Name: 3-Oxocyclobutanecarboxylic acid
CAS No.: 23761-23-1
Chemical Name: 3-Oxocyclobutanecarboxylic acid
Synonyms: 3-oxocyclobutane-1-carboxylic acid;3-OXO-CYCLOBUTANECARBOXYLIC ACID;3-oxocyclobutane-1,1-dicarboxylic acid;3-OxocycL;IFLAB-BB F2124-0041;1-Carboxy-3-oxocyclobutane;3-Oxocyclobutanecarboxylic;3-Oxocyclobutanecarboxyli...;Oxocyclobutanecarboxylic acid;3-Oxycyclobutanecarboxylic acid
CBNumber: CB0111483
Molecular Formula: C5H6O3
Formula Weight: 114.1
MOL File: 23761-23-1.mol

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3-Oxocyclobutanecarboxylic acid Property

Melting point:: 69-70℃
Boiling point:: 296°C
Density: 1.431
Flash point:: 147°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Solid
pka: 4.35±0.20(Predicted)
color: Off-white
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C5H6O3/c6-4-1-3(2-4)5(7)8/h3H,1-2H2,(H,7,8)
InChIKey: IENOFRJPUPTEMI-UHFFFAOYSA-N
SMILES: C1(C(O)=O)CC(=O)C1
CAS DataBase Reference: 23761-23-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 26-37-60
TSCA: No
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS004694
Product name: 3-Oxocyclobutanecarboxylic acid
Purity: AldrichCPR
Packaging: 100mg
Price: $70.9
Updated: 2024/03/01

TCI Chemical

Product number: O0392
Product name: 3-Oxocyclobutanecarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: O0392
Product name: 3-Oxocyclobutanecarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $52
Updated: 2024/03/01

Alfa Aesar

Product number: H64774
Product name: 3-Oxocyclobutanecarboxylic acid, 98%
Packaging: 5g
Price: $51.65
Updated: 2024/03/01

Alfa Aesar

Product number: H64774
Product name: 3-Oxocyclobutanecarboxylic acid, 98%
Packaging: 25g
Price: $207.65
Updated: 2024/03/01

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3-Oxocyclobutanecarboxylic acid Chemical Properties,Usage,Production

Description

3-Oxocyclobutanecarboxylic acid is an organic common intermediate compound used in pharmaceuticals, organic synthesis and organic light-emitting diode (OLED) intermediates. Abrocitinib, prepared from 3-Oxocyclobutanecarboxylic acid, is approved for the treatment of adult patients with atopic dermatitis (AD), as well as patients with refractory moderate to severe AD who have had limited or minimal response to other systemic medications.

Chemical Properties

White solid

Uses

3-Oxocyclobutanecarboxylic Acid (cas# 23761-23-1) is a compound useful in organic synthesis.

Application

3-Oxocyclobutanecarboxylic acid is a very important medicine intermediate, it is widely applied in the synthetic of tens kinds of bulk drugs, such as ACK1 antibody, the MDM2 antagonist, the JAK inhibitor, CETP inhibitor, kinase inhibitor, the PDE10 inhibitor, thrombin inhibitors and in autoimmunization chronic inflammatory diseases and antitumor drug, all being used to.

Preparation

The target product 3-oxocyclobutanecarboxylic acid is obtained by adopting acetone, bromine, and malononitrile as raw materials, adopting ethanol, DMF (dimethyl formamide), and water as solvents, adopting sodium iodide as an activating agent and tetrabutylammonium bromide (TBAB) as a phase transfer catalyst through three-step reaction.

Synthesis Reference(s)

The Journal of Organic Chemistry, 53, p. 3841, 1988 DOI: 10.1021/jo00251a033

3-Oxocyclobutanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Oxocyclobutanecarboxylic acid Suppliers

Americas 1 Canada 3 China 429 Europe 1 Germany 2 India 35 Japan 1 Switzerland 2 Ukraine 2 United Kingdom 6 United States 36 Global 518

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View Lastest Price from 3-Oxocyclobutanecarboxylic acid manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 3-Oxocyclobutanecarboxylic acid 23761-23-1
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-15

Hebei Weibang Biotechnology Co., Ltd

Product: 3-Oxocyclobutanecarboxylic acid 23761-23-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-14

Hebei Dangtong Import and export Co LTD

Product: 3-Oxocyclobutanecarboxylic acid 23761-23-1
Price: US $874.00-862.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-02

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