Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester
- Product Name
- Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester
- CAS No.
- 4934-99-0
- Chemical Name
- Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester
- Synonyms
- methyl 3-hydroxycyclobutane-1-carboxylate;Methyl 3-hydroxycyclobuta...;methyl 3-hydroxycyclobutanecarboxylate;3-Hydroxycyclobutanecarboxylic acid methyl ester;3-hydroxy-1-cyclobutanecarboxylic acid methyl ester;Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester;Methylester of 3-hydroxycyclobutane-1-carboxylic acid;Methyl 3-Hydroxycyclobutanecarboxylate (mixture of cis- and trans-)
- CBNumber
- CB92525069
- Molecular Formula
- C6H10O3
- Formula Weight
- 130.14
- MOL File
- 4934-99-0.mol
Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester Property
- Boiling point:
- 190℃
- Density
- 1.232
- Flash point:
- 76℃
- storage temp.
- 2-8°C
- pka
- 14.73±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C6H10O3/c1-9-6(8)4-2-5(7)3-4/h4-5,7H,2-3H2,1H3
- InChIKey
- BYKHAEUVLSBWSU-UHFFFAOYSA-N
- SMILES
- C1(C(OC)=O)CC(O)C1
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 6687AB
- Product name
- Methyl3-hydroxycyclobutanecarboxylate
- Packaging
- 5g
- Price
- $146
- Updated
- 2021/12/16
- Product number
- 068649
- Product name
- Methyl 3-hydroxycyclobutanecarboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 2229-1-28
- Product name
- Methyl 3-hydroxycyclobutanecarboxylate
- Packaging
- 1g
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 068649
- Product name
- Methyl 3-hydroxycyclobutanecarboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 2229-1-28
- Product name
- Methyl 3-hydroxycyclobutanecarboxylate
- Packaging
- 5G
- Price
- $320
- Updated
- 2021/12/16
Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester Chemical Properties,Usage,Production
Synthesis
695-95-4
4934-99-0
General procedure for the synthesis of methyl 3-hydroxycyclobutanecarboxylate from methyl 3-carbonyl-cyclobutanecarboxylate: Methyl 3-carbonyl-cyclobutanecarboxylate (307.5 g, 2.4 mol, 1.0 eq.) was dissolved in 3 L of tetrahydrofuran and the solution was cooled down to -78 to -60 °C. Subsequently, 3.5 L of tetrahydrofuran solution of lithium hydrogenated tri-tert-butoxyaluminum (915.4 g, 3.6 mol, 1.5 eq.) was added slowly and dropwise. After 3 hours of reaction, the completion of the reaction was confirmed by TLC. Then, 1 L of 2.5 mol/L hydrochloric acid was added dropwise to terminate the reaction and the pH of the reaction solution was adjusted to about 6 while the temperature was controlled at about 0 °C. The reaction mixture was diluted by adding 3 L of ethyl acetate and stirred for 30 minutes. The reaction mixture was filtered through diatomaceous earth and the filter cake was washed three times with ethyl acetate. The filtrate was separated and the aqueous phase was extracted with ethyl acetate. All organic phases were combined and concentrated by drying to give a yellow liquid methyl cis-3-hydroxycyclobutanecarboxylate (273.3 g, 2.1 mol) in 88% yield and 95% purity.
References
[1] Patent: CN107903161, 2018, A. Location in patent: Paragraph 0025; 0026; 0027; 0028; 0029; 0030; 0031; 0032
[2] Patent: WO2017/48675, 2017, A1. Location in patent: Paragraph 0480
[3] Patent: CN106478651, 2017, A. Location in patent: Paragraph 1112; 1113; 1114
[4] Patent: CN104447583, 2016, B. Location in patent: Paragraph 0160; 0161; 0162
[5] Patent: CN104447747, 2016, B. Location in patent: Paragraph 0176-0177
Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester manufacturers
- Product
- Methyl 3-hydroxycyclobuta 4934-99-0
- Price
- US $1.00-2.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-08-13
- Product
- Methyl 3-hydroxycyclobuta... 4934-99-0
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-08
- Product
- Methyl 3-hydroxycyclobuta... 4934-99-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-11-18