BENZYL 3-OXOCYCLOBUTYLCARBAMATE

Product Name: BENZYL 3-OXOCYCLOBUTYLCARBAMATE
CAS No.: 130369-36-7
Chemical Name: BENZYL 3-OXOCYCLOBUTYLCARBAMATE
Synonyms: benzyl N-(3-oxocyclobutyl)carbamate;(3-Oxocyclobutyl)carbamic acid phenylmethyl ester;3-(Cbz-amino)cyclobutanone;3-Z-amino-cyclobutanone, 98%;BENZYL 3-OXOCYCLOBUTYLCARBAMATE;3-Aminocyclobutanone, N-CBZ protected;Phenylmethyl N-(3-oxocyclobutyl)carbamate;3-Aminocyclobutanone, N-CBZ protected 97%;Benzyl 3-oxocyclobutylcarbamate - [B12364];N-(Benzyloxycarbonyl)-3-amino-1-cyclobutanone
CBNumber: CB82468910
Molecular Formula: C12H13NO3
Formula Weight: 219.24
MOL File: 130369-36-7.mol

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BENZYL 3-OXOCYCLOBUTYLCARBAMATE Property

Boiling point:: 403.3±44.0 °C(Predicted)
Density: 1.22
storage temp.: 2-8°C
pka: 11.39±0.20(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C12H13NO3/c14-11-6-10(7-11)13-12(15)16-8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H,13,15)
InChIKey: PSAMWNBBHLUISE-UHFFFAOYSA-N
SMILES: C(OCC1=CC=CC=C1)(=O)NC1CC(=O)C1

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Safety

HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: B315753
Product name: Benzyl3-Oxocyclobutylcarbamate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B315753
Product name: Benzyl3-Oxocyclobutylcarbamate
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Synthonix

Product number: B12364
Product name: Benzyl3-oxocyclobutylcarbamate
Purity: 97.0%
Packaging: 1g
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43563
Product name: Benzyl 3-oxocyclobutylcarbamate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43563
Product name: Benzyl 3-oxocyclobutylcarbamate
Packaging: 1g
Price: $100
Updated: 2021/12/16

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BENZYL 3-OXOCYCLOBUTYLCARBAMATE Chemical Properties,Usage,Production

Uses

Benzyl 3-Oxocyclobutylcarbamate is used in process for preparation of abrocitinib.

Synthesis

23761-23-1

100-51-6

130369-36-7

3-Oxocyclobutanecarboxylic acid (1.0 g, 8.77 mmol) and benzyl alcohol (1.14 g, 10.52 mmol) were used as raw materials, and 3-oxocyclobutanecarboxylic acid was mixed with DIEA (1.92 g, 14.92 mmol) and DPPA (2.89 g, 10.52 mmol) in toluene (8 mL) under argon protection. The reaction mixture was heated to 60 °C and maintained for 3 h. Benzyl alcohol was then added. Stirring was continued at 60 °C overnight. Upon completion of the reaction, the reaction mixture was concentrated and the residue was purified by silica gel column chromatography (petroleum ether:ethyl acetate = 8:1) to afford the target product benzyl 3-oxocyclobutylcarbamate (240 mg, 50% yield). The product was characterized by 1H NMR (500 MHz, CDCl3) and ESI-MS: 1H NMR δ 7.38-7.33 (m, 5H), 5.12 (d, J = 7.5 Hz, 2H), 4.34-4.33 (brs, 1H), 3.44-3.39 (m, 2H), 3.10-3.07 (brs, 2H) ppm; ESI-MS (m/z): 220.2 [M + 1]+.

References

[1] Patent: WO2012/75381, 2012, A1. Location in patent: Page/Page column 210
[2] Patent: WO2012/9678, 2012, A1. Location in patent: Page/Page column 210
[3] Patent: EP1256578, 2002, A1. Location in patent: Page 22
[4] Patent: WO2014/74421, 2014, A1. Location in patent: Page/Page column 56; 57

BENZYL 3-OXOCYCLOBUTYLCARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZYL 3-OXOCYCLOBUTYLCARBAMATE Suppliers

China 109 Germany 1 India 4 United Kingdom 3 United States 10 Global 127

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View Lastest Price from BENZYL 3-OXOCYCLOBUTYLCARBAMATE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: BENZYL 3-OXOCYCLOBUTYLCARBAMATE 130369-36-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Career Henan Chemical Co

Product: BENZYL 3-OXOCYCLOBUTYLCARBAMATE 130369-36-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%
Supply Ability: 100kg
Release date: 2020-02-01

130369-36-7, BENZYL 3-OXOCYCLOBUTYLCARBAMATERelated Search:

ETHYL 3-OXO CYCLOBUATNE CARBOXYLATE 3-Oxocyclobutanecarboxylic acid Cyclobutanone CYCLOBUTYLHYDRAZINE DIHYDROCHLORIDE 1-CYCLOBUTYLHYDRAZINE HYDROCHLORIDE N-Boc-1-aminocyclobutanecarboxylic acid Carbamic acid, (3-hydroxycyclobutyl)-, 1,1-dimethylethyl ester (9CI) 3-PHENYL-CYCLOBUTAN-1-ONE 3-Methylenecyclobutanecarbonitrile Cyclobutylmethylamine hydrochloride 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 2-AMINO-3-BROMOPHENOL 3-IODO-4-METHOXY-5-AZAINDOLE 1-(5-Bromo-2-fluoropyridin-3-yl)ethanone 4,5-DICHLOROPHTHALIC ACID 1H-Pyrrolo[3,2-c]pyridine-3-carboxylic acid, 6-bromo- 6-CHLORO-5-AZAINDOLE (3-BroMo-pyridin-2-yl)-acetic acid ethyl ester

3-Aminocyclobutanone, N-CBZ protected 97%

BENZYL 3-OXOCYCLOBUTYLCARBAMATE

(3-Oxo-cyclobutyl)-carbamic acid benzyl ester

N-(Benzyloxycarbonyl)-3-amino-1-cyclobutanone

(3-Oxocyclobutyl)carbamic acid phenylmethyl ester

benzyl N-(3-oxocyclobutyl)carbamate

Carbamic acid, N-(3-oxocyclobutyl)-, phenylmethyl ester

3-Z-amino-cyclobutanone, 98%

3-(Cbz-amino)cyclobutanone

Phenylmethyl N-(3-oxocyclobutyl)carbamate

3-Aminocyclobutanone, N-CBZ protected

Benzyl 3-oxocyclobutylcarbamate - [B12364]

130369-36-7

130396-36-7