N-Boc-1-aminocyclobutanecarboxylic acid

Product Name: N-Boc-1-aminocyclobutanecarboxylic acid
CAS No.: 120728-10-1
Chemical Name: N-Boc-1-aminocyclobutanecarboxylic acid
Synonyms: BOC-ACBC-OH;BOC-AC4C-OH;BOC-1, 1-ACCB;BOC-CYCLOVALINE;Boc-1-Aminocyclobutanecarboxylic acid;Boc-1-aminocyclobutane-1-carboxylicaci;1-(BOC-AMINO)CYCLOBUTANECARBOXYLIC ACID;N-BOC-1-AMINOCYCLOBUTANE CARBOXYLIC ACID;BOC-1-AMINOCYCLOBUTANE-1-CARBOXYLIC ACID;BOC-1-AMINO-1-CYCLOBUTANECARBOXYLIC ACID
CBNumber: CB7110182
Molecular Formula: C10H17NO4
Formula Weight: 215.25
MOL File: 120728-10-1.mol

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N-Boc-1-aminocyclobutanecarboxylic acid Property

Melting point:: 129-133 °C(lit.)
Boiling point:: 362.1±21.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 4.14±0.20(Predicted)
form: Powder
color: White to light brown
BRN: 7994003
InChI: InChI=1S/C10H17NO4/c1-9(2,3)15-8(14)11-10(7(12)13)5-4-6-10/h4-6H2,1-3H3,(H,11,14)(H,12,13)
InChIKey: ROVVUKFHORPDSM-UHFFFAOYSA-N
SMILES: C1(NC(OC(C)(C)C)=O)(C(O)=O)CCC1
CAS DataBase Reference: 120728-10-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 630802
Product name: N-Boc-1-aminocyclobutane carboxylic acid
Purity: 97%
Packaging: 1g
Price: $98.9
Updated: 2023/06/20

Sigma-Aldrich

Product number: 630802
Product name: N-Boc-1-aminocyclobutane carboxylic acid
Purity: 97%
Packaging: 5g
Price: $419
Updated: 2023/06/20

TCI Chemical

Product number: B6086
Product name: N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
Packaging: 1G
Price: $26
Updated: 2024/03/01

TCI Chemical

Product number: B6086
Product name: N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
Packaging: 5G
Price: $79
Updated: 2024/03/01

Alfa Aesar

Product number: H62888
Product name: 1-(Boc-amino)cyclobutanecarboxylic acid, 97%
Packaging: 5g
Price: $179
Updated: 2021/12/16

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N-Boc-1-aminocyclobutanecarboxylic acid Chemical Properties,Usage,Production

Uses

Boc-1-aminocyclobutane-1-carboxylic Acid is used in the synthesis of dipeptidyl nitriles with cathepsin-inhibiting activities. It is also used to prepare alkyl-oxo-aryl amides as novel antagonists of TRPA1 receptor.

Synthesis

Under stirring, add 1-aminocyclobutylcarboxylic acid (500mg, 4.34mmol) to 10mL of 0.5M sodium hydroxide solution, and add 10mL of 1,4-dioxane and di-tert-butyl dicarbonate (1.42g, 6.51 mmol), react for 15 hours. Extract with diethyl ether (20 mL × 2), add hydrochloric acid dropwise until the pH of the aqueous phase is 4, and extract with ethyl acetate (30 mL × 3). The organic phases were then combined, washed with saturated sodium chloride solution (20mL×2), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain the product N-Boc-1-aminocyclobutanecarboxylic acid (750mg, white solid), yield:80.6%.

N-Boc-1-aminocyclobutanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-1-aminocyclobutanecarboxylic acid Suppliers

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View Lastest Price from N-Boc-1-aminocyclobutanecarboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N-Boc-1-aminocyclobutanecarboxylic acid 120728-10-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Career Henan Chemical Co

Product: N-Boc-1-aminocyclobutanecarboxylic acid 120728-10-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2019-08-05

120728-10-1, N-Boc-1-aminocyclobutanecarboxylic acidRelated Search:

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BOC-1-AMINO-1-CYCLOBUTANECARBOXYLIC ACID

BOC-1, 1-ACCB

Boc-1-Aminocyclobutanecarboxylic acid

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1-(tert-butoxycarbonyl)cyclobutanecarboxylic acid

1-(tert-butoxycarbonylaMino)cyclobutanecarboxylic

1-[(tert-Butoxycarbonyl)amino]cyclobutane-1-carboxylic acid, tert-Butyl (1-carboxycyclobut-1-yl)carbamate

1-Aminocyclobutane-1-carboxylic acid, N-BOC protected 97%

Boc-1-aminocyclobutane-1-carboxylicaci

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N-Boc-1-aminocyclobutanecarboxylic acid USP/EP/BP

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N-Boc-1-amino-1-cyclobutane carboxylic acid

N-Boc-amino-1-cyclobutanecarboxylic acid

120728-10-1

20728-10-1

CH33CO2CNHC4H6CO2H

Alicyclic Amino Acids

Unnatural Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Peptide

pharmacetical

Amino Acids and Derivatives

LG

White solid