N-Boc-1-aminocyclobutanecarboxylic acid
- Product Name
- N-Boc-1-aminocyclobutanecarboxylic acid
- CAS No.
- 120728-10-1
- Chemical Name
- N-Boc-1-aminocyclobutanecarboxylic acid
- Synonyms
- BOC-ACBC-OH;BOC-AC4C-OH;BOC-1, 1-ACCB;BOC-CYCLOVALINE;Boc-1-Aminocyclobutanecarboxylic acid;Boc-1-aminocyclobutane-1-carboxylicaci;1-(BOC-AMINO)CYCLOBUTANECARBOXYLIC ACID;N-BOC-1-AMINOCYCLOBUTANE CARBOXYLIC ACID;BOC-1-AMINOCYCLOBUTANE-1-CARBOXYLIC ACID;BOC-1-AMINO-1-CYCLOBUTANECARBOXYLIC ACID
- CBNumber
- CB7110182
- Molecular Formula
- C10H17NO4
- Formula Weight
- 215.25
- MOL File
- 120728-10-1.mol
N-Boc-1-aminocyclobutanecarboxylic acid Property
- Melting point:
- 129-133 °C(lit.)
- Boiling point:
- 362.1±21.0 °C(Predicted)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 4.14±0.20(Predicted)
- form
- Powder
- color
- White to light brown
- BRN
- 7994003
- InChI
- InChI=1S/C10H17NO4/c1-9(2,3)15-8(14)11-10(7(12)13)5-4-6-10/h4-6H2,1-3H3,(H,11,14)(H,12,13)
- InChIKey
- ROVVUKFHORPDSM-UHFFFAOYSA-N
- SMILES
- C1(NC(OC(C)(C)C)=O)(C(O)=O)CCC1
- CAS DataBase Reference
- 120728-10-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 630802
- Product name
- N-Boc-1-aminocyclobutane carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $98.9
- Updated
- 2023/06/20
- Product number
- 630802
- Product name
- N-Boc-1-aminocyclobutane carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $419
- Updated
- 2023/06/20
- Product number
- B6086
- Product name
- N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
- Packaging
- 1G
- Price
- $26
- Updated
- 2024/03/01
- Product number
- B6086
- Product name
- N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
- Packaging
- 5G
- Price
- $79
- Updated
- 2024/03/01
- Product number
- H62888
- Product name
- 1-(Boc-amino)cyclobutanecarboxylic acid, 97%
- Packaging
- 5g
- Price
- $179
- Updated
- 2021/12/16
N-Boc-1-aminocyclobutanecarboxylic acid Chemical Properties,Usage,Production
Uses
Boc-1-aminocyclobutane-1-carboxylic Acid is used in the synthesis of dipeptidyl nitriles with cathepsin-inhibiting activities. It is also used to prepare alkyl-oxo-aryl amides as novel antagonists of TRPA1 receptor.
Synthesis
Under stirring, add 1-aminocyclobutylcarboxylic acid (500mg, 4.34mmol) to 10mL of 0.5M sodium hydroxide solution, and add 10mL of 1,4-dioxane and di-tert-butyl dicarbonate (1.42g, 6.51 mmol), react for 15 hours. Extract with diethyl ether (20 mL × 2), add hydrochloric acid dropwise until the pH of the aqueous phase is 4, and extract with ethyl acetate (30 mL × 3). The organic phases were then combined, washed with saturated sodium chloride solution (20mL×2), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain the product N-Boc-1-aminocyclobutanecarboxylic acid (750mg, white solid), yield:80.6%.
N-Boc-1-aminocyclobutanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
N-Boc-1-aminocyclobutanecarboxylic acid Suppliers
View Lastest Price from N-Boc-1-aminocyclobutanecarboxylic acid manufacturers
- Product
- N-Boc-1-aminocyclobutanecarboxylic acid 120728-10-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- N-Boc-1-aminocyclobutanecarboxylic acid 120728-10-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2019-08-05