ChemicalBook > CAS DataBase List > N-Boc-1-aminocyclobutanecarboxylic acid

N-Boc-1-aminocyclobutanecarboxylic acid

Product Name
N-Boc-1-aminocyclobutanecarboxylic acid
CAS No.
120728-10-1
Chemical Name
N-Boc-1-aminocyclobutanecarboxylic acid
Synonyms
BOC-ACBC-OH;BOC-AC4C-OH;Boc-cVal-OH;BOC-1, 1-ACCB;BOC-CYCLOVALINE;Boc-1-Aminocyclobutanecarboxylic acid;Boc-1-aminocyclobutane-1-carboxylicaci;1-(BOC-AMINO)CYCLOBUTANECARBOXYLIC ACID;N-BOC-1-AMINOCYCLOBUTANE CARBOXYLIC ACID;BOC-1-AMINOCYCLOBUTANE-1-CARBOXYLIC ACID
CBNumber
CB7110182
Molecular Formula
C10H17NO4
Formula Weight
215.25
MOL File
120728-10-1.mol
More
Less

N-Boc-1-aminocyclobutanecarboxylic acid Property

Melting point:
129-133 °C(lit.)
Boiling point:
362.1±21.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
4.14±0.20(Predicted)
form 
Powder
color 
White to light brown
BRN 
7994003
InChI
InChI=1S/C10H17NO4/c1-9(2,3)15-8(14)11-10(7(12)13)5-4-6-10/h4-6H2,1-3H3,(H,11,14)(H,12,13)
InChIKey
ROVVUKFHORPDSM-UHFFFAOYSA-N
SMILES
C1(NC(OC(C)(C)C)=O)(C(O)=O)CCC1
CAS DataBase Reference
120728-10-1(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29242990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
630802
Product name
N-Boc-1-aminocyclobutane carboxylic acid
Purity
97%
Packaging
1g
Price
$98.9
Updated
2023/06/20
Sigma-Aldrich
Product number
630802
Product name
N-Boc-1-aminocyclobutane carboxylic acid
Purity
97%
Packaging
5g
Price
$419
Updated
2023/06/20
TCI Chemical
Product number
B6086
Product name
N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
Packaging
1G
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
B6086
Product name
N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
Packaging
5G
Price
$79
Updated
2024/03/01
Alfa Aesar
Product number
H62888
Product name
1-(Boc-amino)cyclobutanecarboxylic acid, 97%
Packaging
5g
Price
$179
Updated
2021/12/16
More
Less

N-Boc-1-aminocyclobutanecarboxylic acid Chemical Properties,Usage,Production

Description

N-Boc-1-aminocyclobutanecarboxylic acid (1-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid) is an organic compound used in the preparation of intermediates for Boc-apalutamide. Apalutamide is a prescription drug used to treat prostate cancer.

Uses

Boc-1-aminocyclobutane-1-carboxylic Acid is used in the synthesis of dipeptidyl nitriles with cathepsin-inhibiting activities. It is also used to prepare alkyl-oxo-aryl amides as novel antagonists of TRPA1 receptor.

Synthesis

Under stirring, add 1-aminocyclobutylcarboxylic acid (500mg, 4.34mmol) to 10mL of 0.5M sodium hydroxide solution, and add 10mL of 1,4-dioxane and di-tert-butyl dicarbonate (1.42g, 6.51 mmol), react for 15 hours. Extract with diethyl ether (20 mL × 2), add hydrochloric acid dropwise until the pH of the aqueous phase is 4, and extract with ethyl acetate (30 mL × 3). The organic phases were then combined, washed with saturated sodium chloride solution (20mL×2), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain the product N-Boc-1-aminocyclobutanecarboxylic acid (750mg, white solid), yield:80.6%.

N-Boc-1-aminocyclobutanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-Boc-1-aminocyclobutanecarboxylic acid Suppliers

Americas 1 Belgium 1 Canada 2 China 246 Europe 1 France 3 Germany 8 India 11 Japan 5 South Korea 1 Spain 1 Switzerland 3 United Kingdom 8 United States 54 Global 345
Varnor Chemical Co., Ltd.
Tel
0796-8330061 18779971813
Email
sales@varnorchem.com
Country
China
ProdList
66
Advantage
58
Shanghai Arbor Chemical Co., Ltd.
Tel
021-60451682 15021268886
Fax
+86-21-60451682
Email
sales@arborchemical.com
Country
China
ProdList
856
Advantage
55
Varnor Chemical Co., Ltd.
Tel
0796-8330061 18779971813
Fax
0086-796-8330061
Email
sales@varnorchem.com
Country
China
ProdList
21
Advantage
55
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
15523000485
Email
xingcanyaoye@sina.com
Country
China
ProdList
1687
Advantage
58
CE Pharm Co.,Ltd
Tel
15317222985
Fax
binbin.lin@cepharm.cn
Email
bingna.wang@cepharm.cn
Country
China
ProdList
141
Advantage
58
Junyu Chemexpress Co., Ltd.
Tel
0731-88036271 13723890100
Fax
0731-88036271
Email
info@csjyyy.com
Country
China
ProdList
47
Advantage
58
Wuhan Luyi New Material Co., Ltd.
Tel
027-81360608 13971310049
Fax
027-81360608
Email
109321999@qq.com
Country
China
ProdList
72
Advantage
58
Beijing InnoChem Science & Technology Co., Ltd.
Tel
15652467323 15652467323
Email
sales@inno-chem.com.cn
Country
China
ProdList
8293
Advantage
58
Hangzhou Chemtrue Bio-Tech Co.,Ltd.
Tel
0571-86828652 18857119830
Fax
0571-83522824
Email
sales@chemtrue-bio.com
Country
China
ProdList
326
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Sichuan Tongsheng Amino acids Co.,Ltd.
Tel
0838-2809458 13350585791
Fax
+86-838-2274207
Email
pharm@biots.cn
Country
China
ProdList
333
Advantage
66
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Changzhou Huanling Chemical Co., Ltd.
Tel
0519-89803565 13776850645
Fax
0519-89803575
Email
info4@huanlingchem.com
Country
China
ProdList
641
Advantage
68
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9513
Advantage
66
Nanjing Habo Medical Technology Co., Ltd.
Tel
025-85760892 13376090521
Fax
025-85766769
Email
sales@habotech.com
Country
China
ProdList
969
Advantage
60
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Boc Chemical Co.,Ltd
Tel
021-34975603-808 18721111801
Fax
+86-21-34975602-805
Email
sales@bocpharma.com
Country
China
ProdList
997
Advantage
64
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Shanghai Feibo Chemical Technology Co., Ltd
Tel
021-58955608,2250286 15921236618
Email
blinkzeng@gmail.com
Country
China
ProdList
522
Advantage
62
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
shanghai Rainbow MediTech.Co.Ltd.
Tel
21-021-64968085,64968086-5815,5812 13918693646
Fax
+86 21 64968087
Email
bd@rainbowpharma.cn
Country
China
ProdList
976
Advantage
65
Jinan Chenghui Shuangda biological Co., LTD
Tel
0531-58897003 15550412551
Fax
0531-58897003
Email
market@jnchsd.com
Country
China
ProdList
217
Advantage
62
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9458
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
Tel
021-34666753 13311639313
Fax
+86-21-34979012
Email
info@shyrchem.com
Country
China
ProdList
571
Advantage
55
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-021-36680027 15800370750
Email
1706640024@qq.com
Country
China
ProdList
547
Advantage
56
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Shanghai Sheepchem Co., Ltd.
Tel
+86 (21) 6715-7650
Fax
+86 (21) 6715-7651
Email
sheepchem@163.com
Country
China
ProdList
994
Advantage
60
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
028-85122536 15928766785
Fax
QQ961458712
Email
wupengcheng@astatech.cn
Country
China
ProdList
2001
Advantage
55
More
Less

View Lastest Price from N-Boc-1-aminocyclobutanecarboxylic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
N-Boc-1-aminocyclobutanecarboxylic acid 120728-10-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30
Career Henan Chemical Co
Product
N-Boc-1-aminocyclobutanecarboxylic acid 120728-10-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10KG
Release date
2019-08-05

120728-10-1, N-Boc-1-aminocyclobutanecarboxylic acidRelated Search:

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 6-Aminocaproic acid Ethyl 2-(Chlorosulfonyl)acetate Cyclopropane Hyaluronic acid ALTRENOGEST Folic acid ISOBUTANE Sodium N-cyclohexylsulfamate 1,2,3,4-Butanetetracarboxylic acid Citric acid n-Butane Glycine Tris(hydroxymethyl)aminomethane 1-Chloro-2-methylpropane Ascoric Acid Cyclobutylamine 1-AMINO-CYCLOBUTANECARBOXYLIC ACID

  • N-BOC-1-AMINOCYCLOBUTANE CARBOXYLIC ACID
  • 1-AMINOCYCLOBUTYL-1-CARBOXYLIC ACID, N-BOC PROTECTED
  • 1-(BOC-AMINO)CYCLOBUTANECARBOXYLIC ACID
  • 1-N-BOC-AMINO-CYCLOBUTANE CARBOXYLIC ACID
  • 1-(TERT-BUTYLOXYCARBONYL-AMINO)-CYCLOBUTYL-1-CARBOXYLIC ACID
  • 1-Aminocyclobutane-1-carboxylic acid, N-BOC protected
  • Boc-1-amino-1-cyclobutane carboxylic acid, 97.5%
  • 1-TERT-BUTOXYCARBONYLAMINO-CYCLOBUTANECARBOXYLIC ACID
  • 1-(T-BUTYLOXYCARBONYL-AMINO)-CYCLOBUTYL-1-CARBOXYLIC ACID
  • BOC-AC4C-OH
  • BOC-ACBC-OH
  • BOC-CYCLOVALINE
  • BOC-1-AMINOCYCLOBUTANE-1-CARBOXYLIC ACID
  • BOC-1-AMINO-1-CYCLOBUTANECARBOXYLIC ACID
  • BOC-1, 1-ACCB
  • Boc-1-Aminocyclobutanecarboxylic acid
  • N-BOC-1-AMINOCYCLOBUTYL-1-CARBOXYLIC ACID
  • Boc-1-aminocyclobutanecarboxylic acid-OH
  • 1-(Boc-amino)cyclobutanecarboxylic acid, Boc-cyclovaline
  • Cyclobutanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-
  • 1-[(tert-Butoxycarbonyl)amino]cyclobutane-1-carboxylic acid
  • 1N-1-BOC-Aminocyclobutyl-1-carboxylic acid
  • 1-(tert-butoxycarbonylaMino)cyclobutanecarboxylic axid
  • 1-aMino-2-[(tert-butoxy)carbonyl]cyclobutane-1-carboxylic acid
  • 1-(tert-butoxycarbonyl)cyclobutanecarboxylic acid
  • 1-(tert-butoxycarbonylaMino)cyclobutanecarboxylic
  • 1-[(tert-Butoxycarbonyl)amino]cyclobutane-1-carboxylic acid, tert-Butyl (1-carboxycyclobut-1-yl)carbamate
  • 1-Aminocyclobutane-1-carboxylic acid, N-BOC protected 97%
  • Boc-1-aminocyclobutane-1-carboxylicaci
  • N-tert-Butoxycarbonyl-1-aminocyclobutanecarboxylic Acid
  • N-Boc-1-aminocyclobutanecarboxylic acid USP/EP/BP
  • 1-(t-Butoxycarbonyl)aminocyclobutanecarboxylic acid
  • 1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclobutane-1-carboxylic acid
  • N-Boc-1-amino-1-cyclobutane carboxylic acid
  • N-Boc-amino-1-cyclobutanecarboxylic acid
  • Boc-cVal-OH
  • 120728-10-1
  • 20728-10-1
  • CH33CO2CNHC4H6CO2H
  • Alicyclic Amino Acids
  • Unnatural Amino Acid Derivatives
  • Peptide Synthesis
  • Specialty Synthesis
  • Peptide
  • pharmacetical
  • Amino Acids and Derivatives
  • LG
  • White solid