6-CHLORO-5-AZAINDOLE
- Product Name
- 6-CHLORO-5-AZAINDOLE
- CAS No.
- 74976-31-1
- Chemical Name
- 6-CHLORO-5-AZAINDOLE
- Synonyms
- 6-chloro-5-azindole;6-Chloro-5-azaindol;6-CHORO-5-AZAINDOLE;6-CHLORO-5-AZAINDOLE;6-Chloro-1H-pyrrolo[3,2-c]pyridine;1H-Pyrrolo[3,2-c]pyridine, 6-chloro-
- CBNumber
- CB3848546
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 74976-31-1.mol
6-CHLORO-5-AZAINDOLE Property
- Melting point:
- 193-194 °C(Solv: benzene (71-43-2))
- Boiling point:
- 335.8±22.0 °C(Predicted)
- Density
- 1.425±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 14.30±0.40(Predicted)
- color
- Beige
- InChI
- InChI=1S/C7H5ClN2/c8-7-3-6-5(4-10-7)1-2-9-6/h1-4,9H
- InChIKey
- CBHXTZKXDLDMJZ-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC2NC=CC1=2
- CAS DataBase Reference
- 74976-31-1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C364648
- Product name
- 6-Chloro-5-azaindole
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- FC138885
- Product name
- 6-Chloro-5-azaindole
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 3H32-5-2N
- Product name
- 6-Chloro-1H-pyrrolo[3,2-c]pyridine
- Packaging
- 1g
- Price
- $128
- Updated
- 2021/12/16
- Product number
- FC138885
- Product name
- 6-Chloro-5-azaindole
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- W8252
- Product name
- 6-chloro-5-azaindole
- Packaging
- 100mg
- Price
- $62
- Updated
- 2021/12/16
6-CHLORO-5-AZAINDOLE Chemical Properties,Usage,Production
Uses
6-Chloro-5-azaindole is used in preparation of oxodiphenyldihydropyrazolecarboxamide derivatives and analogs for use as ACSS2 inhibitors.
Synthesis
1190862-36-2
74976-31-1
2-Chloro-5-[(E)-2-ethoxyvinyl]pyridin-4-amine (CAS:1190862-36-2, 1.00 g, 5.30 mmol) was used as a raw material, which was dissolved in methanol (20 mL), followed by the addition of concentrated hydrochloric acid (1.00 mL, 32.64 mmol). The reaction mixture was stirred at 75°C for 21 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure, neutralized with saturated aqueous potassium carbonate solution and then extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give 6-chloro-5-azaindole (0.76 g, 99% yield) as a beige solid. The product was detected by mass spectrometry (LRMS), m/z: 153 (M + 1)+; 1H-NMR (CDCl3) δ: 6.65 (m, 1H), 7.20 (s, 2H), 8.60 (m, 2H).
References
[1] Patent: EP2108641, 2009, A1. Location in patent: Page/Page column 49-50
6-CHLORO-5-AZAINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-CHLORO-5-AZAINDOLE manufacturers
- Product
- 6-CHLORO-5-AZAINDOLE 74976-31-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 6-CHLORO-5-AZAINDOLE 74976-31-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 6-CHLORO-5-AZAINDOLE 74976-31-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-03