4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE
- Product Name
- 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE
- CAS No.
- 67139-79-1
- Chemical Name
- 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE
- Synonyms
- Nsc293337;6-dichloro-1H-pyrrolo[3;4,6-Dichloro-5-azaindole ;4,6-Dichloropyrrolo[3,2-c]pyridine;4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE;1H-Pyrrolo[3,2-c]pyridine, 4,6-dichloro-
- CBNumber
- CB2837882
- Molecular Formula
- C7H4Cl2N2
- Formula Weight
- 187.03
- MOL File
- 67139-79-1.mol
4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Property
- Melting point:
- 258 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 371.6±37.0 °C(Predicted)
- Density
- 1.571±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 13.40±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C7H4Cl2N2/c8-6-3-5-4(1-2-10-5)7(9)11-6/h1-3,10H
- InChIKey
- ZTBYPLYMOIIANS-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC2NC=CC1=2
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D482085
- Product name
- 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- D482085
- Product name
- 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- FD148713
- Product name
- 4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- FD148713
- Product name
- 4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine
- Packaging
- 100mg
- Price
- $121
- Updated
- 2021/12/16
- Product number
- FD148713
- Product name
- 4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine
- Packaging
- 50mg
- Price
- $70
- Updated
- 2021/12/16
4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Chemical Properties,Usage,Production
Uses
4,6-dichloro-1H-pyrrolo[3,2-c]pyridine is an organic intermediate that can be used to prepare anti-influenza virus replication inhibitors.
Synthesis
1826-67-1
25194-01-8
67139-79-1
Step A: Synthesis of 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine: 2,6-dichloro-4-nitropyridine (11 g, 57 mmol) was dissolved in anhydrous tetrahydrofuran (300 mL) and cooled to -78 °C. Magnesium vinyl bromide (1M THF solution, 200 mL, 200 mmol) was added dropwise with stirring. The reaction was kept at -78 °C for 1 h, followed by a slow warming to -20 °C. Upon completion of the reaction, the reaction was quenched with 200 mL of saturated aqueous ammonium chloride solution. The reaction mixture was transferred to a partition funnel and the aqueous layer was extracted with ethyl acetate (200 mL x 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by Combi fast chromatography, first using a 120 g silica gel column eluting with a gradient of cyclohexane/ethyl acetate (0-100%), followed by switching to a 40 g silica gel column eluting with a gradient of dichloromethane/ethyl acetate (0-10%) to afford 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine as a brown solid (0.150 g, 1.4% yield) .
References
[1] Patent: WO2013/156431, 2013, A1. Location in patent: Page/Page column 52
4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE manufacturers
- Product
- 4,6-Dichloro-5-azaindole 67139-79-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10
- Product
- 4,6-Dichloro-5-azaindole 67139-79-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09