ChemicalBook > CAS DataBase List > 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE

4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE

Product Name
4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE
CAS No.
67139-79-1
Chemical Name
4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE
Synonyms
Nsc293337;6-dichloro-1H-pyrrolo[3;4,6-Dichloro-5-azaindole ;4,6-Dichloropyrrolo[3,2-c]pyridine;4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE;1H-Pyrrolo[3,2-c]pyridine, 4,6-dichloro-
CBNumber
CB2837882
Molecular Formula
C7H4Cl2N2
Formula Weight
187.03
MOL File
67139-79-1.mol
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4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Property

Melting point:
258 °C(Solv: ethyl acetate (141-78-6))
Boiling point:
371.6±37.0 °C(Predicted)
Density 
1.571±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
13.40±0.40(Predicted)
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C7H4Cl2N2/c8-6-3-5-4(1-2-10-5)7(9)11-6/h1-3,10H
InChIKey
ZTBYPLYMOIIANS-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC2NC=CC1=2
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
D482085
Product name
4,6-dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging
50mg
Price
$110
Updated
2021/12/16
TRC
Product number
D482085
Product name
4,6-dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging
100mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD148713
Product name
4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging
50mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD148713
Product name
4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging
100mg
Price
$121
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD148713
Product name
4,6-Dichloro-1H-pyrrolo[3,2-c]pyridine
Packaging
250mg
Price
$240
Updated
2021/12/16
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4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Chemical Properties,Usage,Production

Uses

4,6-dichloro-1H-pyrrolo[3,2-c]pyridine is an organic intermediate that can be used to prepare anti-influenza virus replication inhibitors.

Synthesis

1826-67-1

25194-01-8

67139-79-1

Step A: Synthesis of 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine: 2,6-dichloro-4-nitropyridine (11 g, 57 mmol) was dissolved in anhydrous tetrahydrofuran (300 mL) and cooled to -78 °C. Magnesium vinyl bromide (1M THF solution, 200 mL, 200 mmol) was added dropwise with stirring. The reaction was kept at -78 °C for 1 h, followed by a slow warming to -20 °C. Upon completion of the reaction, the reaction was quenched with 200 mL of saturated aqueous ammonium chloride solution. The reaction mixture was transferred to a partition funnel and the aqueous layer was extracted with ethyl acetate (200 mL x 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by Combi fast chromatography, first using a 120 g silica gel column eluting with a gradient of cyclohexane/ethyl acetate (0-100%), followed by switching to a 40 g silica gel column eluting with a gradient of dichloromethane/ethyl acetate (0-10%) to afford 4,6-dichloro-1H-pyrrolo[3,2-c]pyridine as a brown solid (0.150 g, 1.4% yield) .

References

[1] Patent: WO2013/156431, 2013, A1. Location in patent: Page/Page column 52

4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE Suppliers

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View Lastest Price from 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE manufacturers

Career Henan Chemical Co
Product
4,6-Dichloro-5-azaindole 67139-79-1
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1ton
Release date
2020-01-10
Career Henan Chemical Co
Product
4,6-Dichloro-5-azaindole 67139-79-1
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09

67139-79-1, 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINERelated Search:

1H-Pyrrolo[3,2-c]pyridine, 7-broMo-4-chloro- 7-CHLORO-4-METHYL-1H-PYRROLO[2,3-C]PYRIDINE 7-CHLORO-5-METHYL-1H-PYRROLO[2,3-C]PYRIDINE 1H-Pyrrolo[2,3-c]pyridine, 4,7-dibroMo- 6-Hydroxy-5-azaindole 4-BROMO-7-METHOXY-6-AZAINDOLE 4-HYDROXY-5-AZAINDOLE 4-METHOXY-5-AZAINDOLE 7-Aza-2-oxindole-6-carboxylic acid Methyl este 3-BROMO-4-METHOXY-5-AZAINDOLE 4-bromo-7-chloro-1H-pyrrolo[2,3-c]pyridine 3-Iodo-7-Methoxy-4-azaindole 4-Methoxy-3-nitro-5-azaindole 1H-Pyrrolo[3,2-c]pyridine, 4-broMo-7-chloro- 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE 4-CHLORO-5-AZAINDOLE Methyl 4,6-dichloro-5-azaindole-2-carboxylate 6-CHLORO-5-AZAINDOLE

  • Nsc293337
  • 6-dichloro-1H-pyrrolo[3
  • 1H-Pyrrolo[3,2-c]pyridine, 4,6-dichloro-
  • 4,6-Dichloro-5-azaindole
  • 4,6-DICHLORO-1H-PYRROLO-[3,2-C]-PYRIDINE
  • 4,6-Dichloropyrrolo[3,2-c]pyridine
  • 67139-79-1
  • CHIRAL CHEMICALS
  • Heterocycle-Pyridine series