ChemicalBook > CAS DataBase List > 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE

2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE

Product Name
2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE
CAS No.
1053228-29-7
Chemical Name
2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE
Synonyms
2,6-dichloro-7-fluoro-7-deaza-9H-purine;2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE;7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-5-fluoro-
CBNumber
CB22567309
Molecular Formula
C6H2Cl2FN3
Formula Weight
206
MOL File
1053228-29-7.mol
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2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Property

Melting point:
234 °C(Solv: dichloromethane (75-09-2))
Density 
1.769±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
8.82±0.50(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B419690
Product name
2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Packaging
100mg
Price
$330
Updated
2021/12/16
Apolloscientific
Product number
PC201011
Product name
2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Purity
98%
Packaging
100mg
Price
$174
Updated
2021/12/16
Apolloscientific
Product number
PC201011
Product name
2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Purity
98%
Packaging
250mg
Price
$277
Updated
2021/12/16
SynQuest Laboratories
Product number
3H31-7-2Z
Product name
2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Purity
98%
Packaging
100mg
Price
$279
Updated
2021/12/16
AK Scientific
Product number
1219AA
Product name
2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Packaging
100mg
Price
$305
Updated
2021/12/16
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2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

90213-66-4

1053228-29-7

2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (200 mg, 1.06 mmol) was used as starting material and dissolved in acetonitrile (5.0 mL). Subsequently, 1-chloromethyl-4-fluoro-1,4-diazabicyclo[2.2.2]octanebis(tetrafluoroborate) (561.6 mg, 1.6 mmol) and acetic acid (1 mL) were added sequentially to this solution. The reaction mixture was heated at 80 °C and stirred continuously for 24 hours. Upon completion of the reaction, the organic layer was separated, dried with anhydrous magnesium sulfate, filtered to remove the desiccant, and the filtrate was subsequently concentrated under reduced pressure. The residue was purified by column chromatography to afford the target compound 2,4-dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (170.0 mg, 80.1% yield). The product was confirmed by NMR hydrogen spectroscopy (500 MHz, CD3OD) with a chemical shift δ of 7.36 (s, 1H).

References

[1] Patent: WO2018/4306, 2018, A1. Location in patent: Page/Page column 91
[2] Patent: WO2017/87905, 2017, A1. Location in patent: Page/Page column 177
[3] Patent: WO2009/131687, 2009, A2. Location in patent: Page/Page column 129
[4] Patent: US2010/204221, 2010, A1. Location in patent: Page/Page column 18
[5] Patent: WO2012/151561, 2012, A1. Location in patent: Page/Page column 58

2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Suppliers

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View Lastest Price from 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE manufacturers

Career Henan Chemical Co
Product
2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE 1053228-29-7
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2018-07-30

1053228-29-7, 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINERelated Search:


  • 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE
  • 7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-5-fluoro-
  • 2,6-dichloro-7-fluoro-7-deaza-9H-purine
  • 1053228-29-7
  • C6H2Cl2FN3