2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE
- Product Name
- 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE
- CAS No.
- 1053228-29-7
- Chemical Name
- 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE
- Synonyms
- 2,6-dichloro-7-fluoro-7-deaza-9H-purine;2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE;7H-Pyrrolo[2,3-d]pyriMidine, 2,4-dichloro-5-fluoro-
- CBNumber
- CB22567309
- Molecular Formula
- C6H2Cl2FN3
- Formula Weight
- 206
- MOL File
- 1053228-29-7.mol
2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Property
- Melting point:
- 234 °C(Solv: dichloromethane (75-09-2))
- Density
- 1.769±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.82±0.50(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B419690
- Product name
- 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- PC201011
- Product name
- 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 98%
- Packaging
- 100mg
- Price
- $174
- Updated
- 2021/12/16
- Product number
- PC201011
- Product name
- 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $277
- Updated
- 2021/12/16
- Product number
- 3H31-7-2Z
- Product name
- 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
- Purity
- 98%
- Packaging
- 100mg
- Price
- $279
- Updated
- 2021/12/16
- Product number
- 1219AA
- Product name
- 2,4-Dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production
Synthesis
90213-66-4
1053228-29-7
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine (200 mg, 1.06 mmol) was used as starting material and dissolved in acetonitrile (5.0 mL). Subsequently, 1-chloromethyl-4-fluoro-1,4-diazabicyclo[2.2.2]octanebis(tetrafluoroborate) (561.6 mg, 1.6 mmol) and acetic acid (1 mL) were added sequentially to this solution. The reaction mixture was heated at 80 °C and stirred continuously for 24 hours. Upon completion of the reaction, the organic layer was separated, dried with anhydrous magnesium sulfate, filtered to remove the desiccant, and the filtrate was subsequently concentrated under reduced pressure. The residue was purified by column chromatography to afford the target compound 2,4-dichloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (170.0 mg, 80.1% yield). The product was confirmed by NMR hydrogen spectroscopy (500 MHz, CD3OD) with a chemical shift δ of 7.36 (s, 1H).
References
[1] Patent: WO2018/4306, 2018, A1. Location in patent: Page/Page column 91
[2] Patent: WO2017/87905, 2017, A1. Location in patent: Page/Page column 177
[3] Patent: WO2009/131687, 2009, A2. Location in patent: Page/Page column 129
[4] Patent: US2010/204221, 2010, A1. Location in patent: Page/Page column 18
[5] Patent: WO2012/151561, 2012, A1. Location in patent: Page/Page column 58
2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE manufacturers
- Product
- 2,4-DICHLORO-5-FLUORO-7H-PYRROLO[2,3-D]PYRIMIDINE 1053228-29-7
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-07-30