NVP-HSP990(HSP990)
- Product Name
- NVP-HSP990(HSP990)
- CAS No.
- 934343-74-5
- Chemical Name
- NVP-HSP990(HSP990)
- Synonyms
- CS-786;HSP-990;NVP-HSP990;NVP-HSP990(HSP990);HSP990 (NVP-HSP990);NVP-HSP990(HSP990) USP/EP/BP;(7R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d;(R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one;(R)-2-Amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one;(7R)-2-AMINO-7-[4-FLUORO-2-(6-METHOXYPYRIDIN-2-YL)PHENYL]-4-METHYL-7,8-DIHYDRO-6H-PYRIDO[4,3-D]PYRIMIDIN-5-ONE
- CBNumber
- CB22570378
- Molecular Formula
- C20H18FN5O2
- Formula Weight
- 379.39
- MOL File
- 934343-74-5.mol
NVP-HSP990(HSP990) Property
- Density
- 1.332
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥12.3 mg/mL in DMSO
- form
- solid
- color
- Off-white to yellow
Safety
- HS Code
- 29339900
N-Bromosuccinimide Price
- Product number
- 19149
- Product name
- HSP-990
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19149
- Product name
- HSP-990
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 19149
- Product name
- HSP-990
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 19149
- Product name
- HSP-990
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $573
- Updated
- 2024/03/01
- Product number
- N925900
- Product name
- NVP-HSP990
- Packaging
- 5mg
- Price
- $520
- Updated
- 2021/12/16
NVP-HSP990(HSP990) Chemical Properties,Usage,Production
Uses
NVP-HSP990 is an orally available HSP90 inhibitor.
Biological Activity
hsp990 (nvp-hsp990) is a potent and selective inhibitor of hsp90 with ic50 values of 0.6, 0.8 and 8.5 nm for hsp90α, hsp90β and grp94, respectively [1].heat shock protein 90 (hsp90) is a chaperone protein that stabilizes proteins against heat stress, assists proteins to fold properly and aids in protein degradation. also, hsp90 stabilizes proteins required for tumor growth.hsp990 (nvp-hsp990) is a potent and selective hsp90 inhibitor. nvp-hsp990 bound to the n-terminal atp-binding domain of hsp90. nvp-hsp990 inhibited trap1 atpase activity by 90% with ic50 value of 320 nm. in gtl-16 cells, nvp-hsp990 destabilized the hsp90-p23 complex in a concentration- and time-dependent way. also, nvp-hsp990 decreased c-met with ec50 value of 37 nm and induced hsp70 with ec50 value of 20 nm. nvp-hsp990 inhibited erk and akt phosphorylation with ec50 values of 11 and 6 nm respectively and thus inhibited erk and akt activation. in five human tumor cell lines, nvp-hsp990 inhibited cell growth with gi50 values of 4-40 nm [1]. in glioma tumor-initiating cells, nvp-hsp990 inhibited cell growth with ic50 value of 10-500 nm in a dose-dependent way and reduced cdk2 and cdk4, thus disrupting cell-cycle control [2].in the gtl-16 gastric cancer mice model, nvp-hsp990 exhibited antitumor efficacy [1].
References
[1]. menezes dl, taverna p, jensen mr, et al. the novel oral hsp90 inhibitor nvp-hsp990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. mol cancer ther, 2012, 11(3): 730-739.
[2]. fu j, koul d, yao j, et al. novel hsp90 inhibitor nvp-hsp990 targets cell-cycle regulators to ablate olig2-positive glioma tumor-initiating cells. cancer res, 2013, 73(10): 3062-3074.
NVP-HSP990(HSP990) Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-HSP990(HSP990) Suppliers
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View Lastest Price from NVP-HSP990(HSP990) manufacturers
- Product
- NVP-HSP990(HSP990) 934343-74-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13