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NVP-HSP990(HSP990)

Product Name
NVP-HSP990(HSP990)
CAS No.
934343-74-5
Chemical Name
NVP-HSP990(HSP990)
Synonyms
CS-786;HSP-990;NVP-HSP990;NVP-HSP990(HSP990);HSP990 (NVP-HSP990);NVP-HSP990, 10 mM in DMSO;HSP990 (NVP-HSP990) ，S7097;NVP-HSP990(HSP990) USP/EP/BP;(7R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d;(R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one
CBNumber
CB22570378
Molecular Formula
C20H18FN5O2
Formula Weight
379.39
MOL File
934343-74-5.mol
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NVP-HSP990(HSP990) Property

Density 
1.332
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥12.3 mg/mL in DMSO
form 
solid
color 
Off-white to yellow
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19149
Product name
HSP-990
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
19149
Product name
HSP-990
Purity
≥98%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
19149
Product name
HSP-990
Purity
≥98%
Packaging
10mg
Price
$283
Updated
2024/03/01
Cayman Chemical
Product number
19149
Product name
HSP-990
Purity
≥98%
Packaging
25mg
Price
$573
Updated
2024/03/01
TRC
Product number
N925900
Product name
NVP-HSP990
Packaging
5mg
Price
$520
Updated
2021/12/16
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NVP-HSP990(HSP990) Chemical Properties,Usage,Production

Uses

NVP-HSP990 is an orally available HSP90 inhibitor.

Biological Activity

hsp990 (nvp-hsp990) is a potent and selective inhibitor of hsp90 with ic50 values of 0.6, 0.8 and 8.5 nm for hsp90α, hsp90β and grp94, respectively [1].heat shock protein 90 (hsp90) is a chaperone protein that stabilizes proteins against heat stress, assists proteins to fold properly and aids in protein degradation. also, hsp90 stabilizes proteins required for tumor growth.hsp990 (nvp-hsp990) is a potent and selective hsp90 inhibitor. nvp-hsp990 bound to the n-terminal atp-binding domain of hsp90. nvp-hsp990 inhibited trap1 atpase activity by 90% with ic50 value of 320 nm. in gtl-16 cells, nvp-hsp990 destabilized the hsp90-p23 complex in a concentration- and time-dependent way. also, nvp-hsp990 decreased c-met with ec50 value of 37 nm and induced hsp70 with ec50 value of 20 nm. nvp-hsp990 inhibited erk and akt phosphorylation with ec50 values of 11 and 6 nm respectively and thus inhibited erk and akt activation. in five human tumor cell lines, nvp-hsp990 inhibited cell growth with gi50 values of 4-40 nm [1]. in glioma tumor-initiating cells, nvp-hsp990 inhibited cell growth with ic50 value of 10-500 nm in a dose-dependent way and reduced cdk2 and cdk4, thus disrupting cell-cycle control [2].in the gtl-16 gastric cancer mice model, nvp-hsp990 exhibited antitumor efficacy [1].

in vivo

NVP-HSP990 (2.5 to 5 mg/kg twice weekly, or 5 to 15 mg/kg weekly, p.o.) causes dose proportional antitumor efficacy, without obvious loss or overt signs of toxicity in a GTL-16 tumor bearing mice. NVP-HSP990 (5 or 10 mg/kg weekly, p.o.) also results in significant inhibition of tumor growth in BT-474 breast cancer model. NVP-HSP990 (5 mg/kg twice weekly or 15 mg/kg weekly, p.o.) inhibits the growth of tumor in the MV4;11 xenograft model. Furthermore, NVP-HSP990 (0.5 mg/kg every day, 14, 5 mg/kg twice weekly, or 15 mg/kg weekly, p.o.) displays antitumor efficacy in H1975 and A549 tumor models[1]. NVP-HSP990 (5, 15 mg/kg, p.o.) shows prolonged suppression of c-Met levels with 30% and 50% reduction and exhibits antitumor activities in GTL-16 tumor xenograft[2].

IC 50

HSP90α: 0.6 nM (IC50); HSP90β: 0.8 nM (IC50); GRP94: 8.5 nM (IC50); TRAP1 ATPase: 320 nM (IC50)

References

[1]. menezes dl, taverna p, jensen mr, et al. the novel oral hsp90 inhibitor nvp-hsp990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. mol cancer ther, 2012, 11(3): 730-739.
[2]. fu j, koul d, yao j, et al. novel hsp90 inhibitor nvp-hsp990 targets cell-cycle regulators to ablate olig2-positive glioma tumor-initiating cells. cancer res, 2013, 73(10): 3062-3074.

NVP-HSP990(HSP990) Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-HSP990(HSP990) Suppliers

China 94 India 2 United States 16 Global 112
Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
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sales@meilune.com
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NCE Biomedical Co.,Ltd.
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+86-27-87599188
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
Email
info@chemexpress.com
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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AdooQ BioScience, LLC
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+1 (866) 930-6790
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+1 (866) 333-9607
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Jinan Mingya Medical Technology Co., Ltd.
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0531-85828981
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+86-531-85806006
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864598798@qq.com
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ChemStrong Scientific Co.,Ltd
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0755-28363542
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sales@chem-strong.com
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
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025-68650336
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Hubei Jusheng Technology Co.,Ltd
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027-59599241 18871490274
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027-59599241
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1400878000@qq.com
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View Lastest Price from NVP-HSP990(HSP990) manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
NVP-HSP990(HSP990) 934343-74-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

934343-74-5, NVP-HSP990(HSP990)Related Search:

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  • (7R)-2-Amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d
  • (7R)-2-AMINO-7-[4-FLUORO-2-(6-METHOXYPYRIDIN-2-YL)PHENYL]-4-METHYL-7,8-DIHYDRO-6H-PYRIDO[4,3-D]PYRIMIDIN-5-ONE
  • (R)-2-Amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one
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  • NVP-HSP990(HSP990) USP/EP/BP
  • NVP-HSP990, 10 mM in DMSO
  • HSP990 (NVP-HSP990) ，S7097
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  • Inhibitors