ChemicalBook > CAS DataBase List > 3,4-(Methylenedioxy)cinnamic acid

3,4-(Methylenedioxy)cinnamic acid

Product Name
3,4-(Methylenedioxy)cinnamic acid
CAS No.
2373-80-0
Chemical Name
3,4-(Methylenedioxy)cinnamic acid
Synonyms
AKOS B004102;AKOS AUF01566;AKOS BBS-00006476;RARECHEM BK HC S236;Piperonylideneacetic;PIPERONYL ACRYLIC ACID;3-PIPERONYLACRYLIC ACID;3,4-Methoxy cinnaMic acid;Piperonylideneacetic acid.;Acetic acid, piperonylidene-
CBNumber
CB2257147
Molecular Formula
C10H8O4
Formula Weight
192.17
MOL File
2373-80-0.mol
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3,4-(Methylenedioxy)cinnamic acid Property

Melting point:
242-244 °C (dec.)(lit.)
Boiling point:
248.14°C (rough estimate)
Density 
1.0825 (rough estimate)
refractive index 
1.4440 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
very faint turbidity in Pyridine
form 
powder to crystal
pka
4.37±0.10(Predicted)
color 
White to Light yellow
BRN 
84599
InChI
InChI=1S/C10H8O4/c11-10(12)4-2-7-1-3-8-9(5-7)14-6-13-8/h1-5H,6H2,(H,11,12)
InChIKey
QFQYZMGOKIROEC-DUXPYHPUSA-N
SMILES
C(O)(=O)C=CC1=CC=C2OCOC2=C1
CAS DataBase Reference
2373-80-0(CAS DataBase Reference)
NIST Chemistry Reference
3,4-Methylenedioxycinnamic acid(2373-80-0)
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Safety

Hazard Codes 
Xi
Risk Statements 
38-36/37/38
Safety Statements 
36-24/25-37-26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
146242
Product name
3,4-(Methylenedioxy)cinnamic acid, predominantly trans
Purity
99%
Packaging
5g
Price
$61.4
Updated
2025/07/31
Sigma-Aldrich
Product number
146242
Product name
3,4-(Methylenedioxy)cinnamic acid, predominantly trans
Purity
99%
Packaging
25g
Price
$240
Updated
2025/07/31
TCI Chemical
Product number
M0634
Product name
3,4-Methylenedioxycinnamic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$107
Updated
2025/07/31
TRC
Product number
M304405
Product name
3,4-(Methylenedioxy)cinnamic acid, predominantly trans
Packaging
5g
Price
$45
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK303371
Product name
3,4-(Methylenedioxy)cinnamicacid,99%,predominantlytrans
Packaging
25g
Price
$59
Updated
2021/12/16
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3,4-(Methylenedioxy)cinnamic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow granular powder

Uses

3,4-(Methylenedioxy)cinnamic acid, predominantly trans is an inhibitor of the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase.

Definition

ChEBI: Methylenedioxycinnamic acid is a hydroxycinnamic acid.

General Description

3,4-(Methylenedioxy)cinnamic acid is an inhibitor of the phenylpropanoid enzyme 4-hydroxycinnamoyl-CoA ligase. It undergoes electron transfer reaction with trichloromethylperoxyl radical and reaction has been studied by pulse radiolysis.

Purification Methods

Crystallise the acid from glacial AcOH, EtOH (m 247o) or aqueous EtOH (m 240-242o), and it has m 242o after sublimation. [Beilstein 19 H 278, 19 II 299, 19 III/IV 3548.]

3,4-(Methylenedioxy)cinnamic acid Preparation Products And Raw materials

Raw materials

Piperonyl aldehyde Piperidine Potassium Acetate

Preparation Products

3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOYL CHLORIDE
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3,4-(Methylenedioxy)cinnamic acid Suppliers

Americas 1 Belgium 3 CHINA 129 Europe 1 Germany 6 India 9 Japan 4 Russia 1 Slovakia 1 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 16 United States 32 Global 209
P&S Chemicals
Tel
--
Fax
--
Email
info@pschemicals.com
Country
The Netherlands
ProdList
2724
Advantage
58
Specs
Tel
--
Fax
--
Email
info@specs.net
Country
The Netherlands
ProdList
6833
Advantage
70
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View Lastest Price from 3,4-(Methylenedioxy)cinnamic acid manufacturers

Career Henan Chemical Co
Product
3,4-(Methylenedioxy)cinnamic acid 2373-80-0
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

2373-80-0, 3,4-(Methylenedioxy)cinnamic acidRelated Search:

Methyl cinnamate Ethyl 4-methoxycinnamate Ethyl cinnamate Octyl 4-methoxycinnamate 4-Bromocinnamic acid trans-Cinnamic acid Cinnamic acid 4-Methoxycinnamic acid 2-BROMO-4,5-METHYLENEDIOXYCINNAMIC ACID 4,5-METHYLENEDIOXY-2-NITROCINNAMIC ACID Acrylic acid ETHYL 3-(1,3-BENZODIOXOL-5-YL)-2-CYANOACRYLATE (2E)-3-(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)PROPENOICACID 4-METHOXYPHENYL (E)-3-(6-BROMO-1,3-BENZODIOXOL-5-YL)-2-PROPENOATE 2-PHENYL-4-PIPERONYLIDENE-2-OXAZOLIN-5-ONE 3-(1,3-BENZODIOXOL-5-YL)-2-CYANOACRYLIC ACID ISOBUTYL ALPHA-CYANO-3,4-METHYLENEDIOXYCINNAMATE METHYL (E)-3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOATE

  • 3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid
  • 3-(3,4-Methylene-dioxphenyl)acrylicacid
  • 3-(3,4-Methylenedioxyphenyl)propenoic acid
  • 3-(3,4-Methylenedioxyphenyl)propenoicacid
  • (2E)-3-(1,3-benzodioxol-5-yl)prop-2-enoic acid
  • 3,4-Methylenedioxybenzene-3-acrylic acid
  • Acetic acid, piperonylidene-
  • Cinnamic acid, 3,4-(methylenebis(oxy))-
  • Cinnamic acid, 3,4-(methylenedioxy)-
  • Piperonylideneacetic
  • (E)-3-BENZO[1,3]DIOXOL-5-YL-ACRYLIC ACID
  • 3-BENZO[1,3]DIOXOL-5-YL-ACRYLIC ACID
  • 3-PIPERONYLACRYLIC ACID
  • AKOS B004102
  • AKOS AUF01566
  • AKOS BBS-00006476
  • 3-(1,3-BENZODIOXOL-5-YL)-2-PROPENOIC ACID
  • 3-(1,3-BENZODIOXOL-5-YL)ACRYLIC ACID
  • 3,4-(METHYLENEDIOXY)CINNAMIC ACID
  • 3-(3,4-METHYLENE DIOXO-PHENYL)-ACROLEIC ACID
  • 3-(3,4-METHYLENEDIOXYPHENYL) ACRYLIC ACID
  • (2E)-3-(1,3-BENZODIOXOL-5-YL)ACRYLIC ACID
  • 3,4-(Methylenedioxy)cinnamic acid, predominantly trans 99%
  • trans-3,4-(Methylenedioxy)cinnamic acid
  • 2-Propenoic acid, 3-(1,3-benzodioxol-5-yl)-
  • 3-(1,3-Benzodioxyl-5-yl)-2-propenoicacid
  • 3-(1,3-Benzodioxol-5-yl)propenoic acid
  • PIPERONYL ACRYLIC ACID
  • RARECHEM BK HC S236
  • 3,4-(METHYLENEDIOXY)CINNAMIC ACID, 99%, PREDOMINANTLY TRANS
  • 3,4-(Methylenedioxy)cinnamic acid, predominantly trans, 99%
  • Piperonylideneacetic acid.
  • 1,3-Benzodioxole-5-acrylic acid
  • 1,3-Benzodioxole-5-propenoic acid
  • 3-(1,3-Benzodioxole-5-yl)propenoic acid
  • 3,4-(Methylenebisoxy)benzeneacrylic acid
  • 2-propenoic acid, 3-(1,3-benzodioxol-5-yl)-, (2E)-
  • (2E)-3-(2H-1,3-benzodioxol-5-yl)prop-2-enoic acid
  • (3,4-Methylendioxy)cinnamic acid
  • 3-(1,3-Benzodioxol-5-yl)acrylic Acid 3-Piperonylacrylic Acid
  • 3,4-Methoxy cinnaMic acid
  • 3,4-MethylenedioxycinnamicAcid&gt
  • 3,4-(Methylenedioxy)cinnamicaci
  • 3,4-(Methylenedioxy)cinnamic acid USP/EP/BP
  • 3,4-(Methylenedioxy)cinnamic acid-99%
  • (E)-3-(1,3-benzodioxol-5-yl)prop-2-enoic acid
  • 3',4'-Methylenedioxycinnamic acid
  • 3,4-(Methylenedioxy)cinnamic acid, 10 mM in DMSO
  • 3,4-(Methylenedioxy)cinnamic acid, predominantly <i>trans</i>
  • 3,4-Methylenedioxycinnamic acid 97%min
  • 2373-80-0
  • C10H8O4
  • Organic Building Blocks
  • Building Blocks
  • Carboxylic Acids
  • Carbonyl Compounds
  • C10
  • Aromatic Cinnamic Acids, Esters and Derivatives