5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine

Product Name: 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine
CAS No.: 1363380-51-1
Chemical Name: 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine
Synonyms: arotrectinib CNPP Impurity;Larotrectinib CNPP Impurity;5-Chloro-3-nitropyrazolo[...;Chloro-3-nitropyrazolo[1,5-a]pyrimidine;5-Chloro-3-nitropyrazolo[1,5-a]pyriMidin;5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine;5-chloro-3-nitropyrazole [1,5-a] pyrimidine;Pyrazolo[1,5-a]pyrimidine, 5-chloro-3-nitro-;5-chloro-3-nitropyrazolo[1,5-a]pyrimidine (Nitro );Larotrectinib Impurity 1（Larotrectinib CNPP Impurity）
CBNumber: CB22582618
Molecular Formula: C6H3ClN4O2
Formula Weight: 198.57
MOL File: 1363380-51-1.mol

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5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine Property

Melting point:: 163 - 165°C
Density: 1.85±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly, Heated), DMSO (Slightly)
form: Solid
pka: -3.59±0.40(Predicted)
color: Purple
InChI: InChI=1S/C6H3ClN4O2/c7-5-1-2-10-6(9-5)4(3-8-10)11(12)13/h1-3H
InChIKey: VYEUPRYCLWAOMU-UHFFFAOYSA-N
SMILES: C12=C([N+]([O-])=O)C=NN1C=CC(Cl)=N2

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C371555
Product name: 5-Chloro-3-nitro-pyrazolo[1,5-a]pyrimidine
Packaging: 250mg
Price: $130
Updated: 2021/12/16

ChemScene

Product number: CS-M3730
Product name: Pyrazolo[1,5-a]pyrimidine,5-chloro-3-nitro-
Purity: 97.75%
Packaging: 5g
Price: $141
Updated: 2021/12/16

ChemScene

Product number: CS-M3730
Product name: Pyrazolo[1,5-a]pyrimidine,5-chloro-3-nitro-
Purity: 97.75%
Packaging: 1g
Price: $33
Updated: 2021/12/16

Apolloscientific

Product number: OR52568
Product name: 5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine
Purity: 97%
Packaging: 5g
Price: $219
Updated: 2021/12/16

AK Scientific

Product number: 0771DW
Product name: 5-Chloro-3-nitropyrazolo[1,5-A]pyrimidine
Packaging: 5g
Price: $228
Updated: 2021/12/16

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5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine Chemical Properties,Usage,Production

Chemical Properties

5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine is a Pale-yellow to Yelow-brown Solid, it can undergo electrophilic and nucleophilic substitution reactions.

Uses

5-Chloro-3-nitro-pyrazolo[1,5-a]pyrimidine is used in the preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, a tyrosine kinase (TRK) inhibitor for treating cancer.

Health Hazard

5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine has acute oral toxicity, it causes skin corrosion/irritation and serious eye damage/eye irritation.

5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine Suppliers

China 145 India 8 United Kingdom 1 United States 8 Global 162

Shandong Zhonghan Pharmaceutical Co.,Ltd.

Tel: 05345026566 18562151612
Email: 2289008634@qq.com
Country: China
ProdList: 296
Advantage: 55

Anhui Dexinjia Biopharm Co., Ltd

Tel: 0531-82375892 15562613975
Email: 34116953599@qq.com
Country: China
ProdList: 293
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Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
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Energy Chemical

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Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44802
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Adamas Reagent, Ltd.

Tel: 400-6009262 15618770481
Fax: 021-64823266
Email: yhx@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
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Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
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Country: China
ProdList: 492
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Synthetics China Co.,Ltd

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Email: cliff.ji@pharmsyn.com
Country: China
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Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9520
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SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 21-33585366 13311639313
Fax: +86-21-34979012
Email: sales@shyrchem.com
Country: China
ProdList: 806
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View Lastest Price from 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine 1363380-51-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-16

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine 1363380-51-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Hebei Yanxi Chemical Co., Ltd.

Product: 5-Chloro-3-nitropyrazolo[1,5-a]pyriMidine 1363380-51-1
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-07

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1363380-51-1