PKI-402
- Product Name
- PKI-402
- CAS No.
- 1173204-81-3
- Chemical Name
- PKI-402
- Synonyms
- CS-167;PKI-402;PKI-402;PKI402;PKI-402 USP/EP/BP;1-(4-(3-Ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(4-(4-methylpiper;1-(4-(3-ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea;1-(4-(3-ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(4-(1-methylpiperazine-4-carbonyl)phenyl)urea;1-[4-[3-Ethyl-7-(morpholin-4-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl]-3-[4-[(4-methylpiperazin-1-yl)carbonyl]phenyl]urea;Urea, N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-
- CBNumber
- CB22582890
- Molecular Formula
- C29H34N10O3
- Formula Weight
- 570.65
- MOL File
- 1173204-81-3.mol
PKI-402 Property
- Boiling point:
- 670.6±55.0 °C(Predicted)
- Density
- 1.43
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥14.28 mg/mL in DMSO
- form
- solid
- pka
- 13.80±0.70(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27664
- Product name
- PKI-402
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 27664
- Product name
- PKI-402
- Packaging
- 25mg
- Price
- $957
- Updated
- 2024/03/01
- Product number
- 27664
- Product name
- PKI-402
- Packaging
- 5mg
- Price
- $233
- Updated
- 2024/03/01
- Product number
- 27664
- Product name
- PKI-402
- Packaging
- 10mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- P571590
- Product name
- PKI402
- Packaging
- 1mg
- Price
- $165
- Updated
- 2021/12/16
PKI-402 Chemical Properties,Usage,Production
Uses
A selective, reversible and ATP-competitive Class I PI3K inhibitor. PI3Kα, IC50=1 nM; PI3Kβ, IC50=7 nM; PI3Kγ, IC50=16 nM; PI3Kδ, IC50=14 nM.
Uses
PKI 402 is a potent pan-PI3K/mTOR dual inhibitor and a potential antitumor drug.
Biological Activity
pki-402 is a selective, equipotent and atp-competitive class i pi3k inhibitor (ic50= 1 nm, 7 nm, 16 nm and 14 nm for pi3kα, pi3kβ, pi3kγ and pi3kδ, respectively.)pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in multiple human cancer cell lines (e.g. breast, brain, pancreas and nscl), pki-402 inhibited growth of cancer cells, and attenuated phosphorylation of effector of pi3k and mtor. in mda-mb-361, 30 nm pki-402 caused cleaved of the apoptosis marker—parp.in mda-mb-361 mouse tumor xenograft models, administration of 100 mg/kg of pki-402 daily for 5 days decreased the initial tumor volume from 260 mm3 to 129 mm3 and inhibited tumor regrowth for 70 days, single dose of pki-402 blocked phosphorylation of akt and led to cleaved parp.1. mallon r, hollander i, feldberg l et al. antitumor efficacy profile of pki-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor. mol cancer ther. 2010 apr;9(4):976-84.
target
PI3Kα
PKI-402 Preparation Products And Raw materials
Raw materials
Preparation Products
PKI-402 Suppliers
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View Lastest Price from PKI-402 manufacturers
- Product
- PKI-402 1173204-81-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23