PKI-402

Product Name: PKI-402
CAS No.: 1173204-81-3
Chemical Name: PKI-402
Synonyms: CS-167;PKI-402;PKI-402;PKI402;PKI-402 USP/EP/BP;1-(4-(3-Ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(4-(4-methylpiper;1-(4-(3-ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea;1-(4-(3-ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(4-(1-methylpiperazine-4-carbonyl)phenyl)urea;1-[4-[3-Ethyl-7-(morpholin-4-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl]-3-[4-[(4-methylpiperazin-1-yl)carbonyl]phenyl]urea;Urea, N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-
CBNumber: CB22582890
Molecular Formula: C29H34N10O3
Formula Weight: 570.65
MOL File: 1173204-81-3.mol

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PKI-402 Property

Boiling point:: 670.6±55.0 °C(Predicted)
Density: 1.43
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥14.28 mg/mL in DMSO
form: solid
pka: 13.80±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27664
Product name: PKI-402
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 27664
Product name: PKI-402
Packaging: 25mg
Price: $957
Updated: 2024/03/01

Cayman Chemical

Product number: 27664
Product name: PKI-402
Packaging: 5mg
Price: $233
Updated: 2024/03/01

Cayman Chemical

Product number: 27664
Product name: PKI-402
Packaging: 10mg
Price: $437
Updated: 2024/03/01

TRC

Product number: P571590
Product name: PKI402
Packaging: 1mg
Price: $165
Updated: 2021/12/16

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PKI-402 Chemical Properties,Usage,Production

Uses

A selective, reversible and ATP-competitive Class I PI3K inhibitor. PI3Kα, IC50=1 nM; PI3Kβ, IC50=7 nM; PI3Kγ, IC50=16 nM; PI3Kδ, IC50=14 nM.

Uses

PKI 402 is a potent pan-PI3K/mTOR dual inhibitor and a potential antitumor drug.

Biological Activity

pki-402 is a selective, equipotent and atp-competitive class i pi3k inhibitor (ic50= 1 nm, 7 nm, 16 nm and 14 nm for pi3kα, pi3kβ, pi3kγ and pi3kδ, respectively.)pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in multiple human cancer cell lines (e.g. breast, brain, pancreas and nscl), pki-402 inhibited growth of cancer cells, and attenuated phosphorylation of effector of pi3k and mtor. in mda-mb-361, 30 nm pki-402 caused cleaved of the apoptosis marker—parp.in mda-mb-361 mouse tumor xenograft models, administration of 100 mg/kg of pki-402 daily for 5 days decreased the initial tumor volume from 260 mm3 to 129 mm3 and inhibited tumor regrowth for 70 days, single dose of pki-402 blocked phosphorylation of akt and led to cleaved parp.1. mallon r, hollander i, feldberg l et al. antitumor efficacy profile of pki-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor. mol cancer ther. 2010 apr;9(4):976-84.

target

PI3Kα

PKI-402 Preparation Products And Raw materials

Raw materials

Preparation Products

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PKI-402 Suppliers

China 69 India 1 United States 18 Global 88

VDM Biochemicals

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View Lastest Price from PKI-402 manufacturers

Career Henan Chemical Co

Product: PKI-402 1173204-81-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1173204-81-3, PKI-402Related Search:

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1-(4-(3-ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(4-(1-methylpiperazine-4-carbonyl)phenyl)urea

1-(4-(3-ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea

PKI-402;PKI402

1-(4-(3-Ethyl-7-morpholino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl)-3-(4-(4-methylpiper

PKI-402

1-[4-[3-Ethyl-7-(morpholin-4-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl]phenyl]-3-[4-[(4-methylpiperazin-1-yl)carbonyl]phenyl]urea

CS-167

Urea, N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-

PKI-402 USP/EP/BP

1173204-81-3

C29H34N10O3

PI3K/Akt/mTOR

Akt

mTOR

PI3K