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1-(3-BroMo-4-fluorophenyl)ethanol

Product Name
1-(3-BroMo-4-fluorophenyl)ethanol
CAS No.
900175-01-1
Chemical Name
1-(3-BroMo-4-fluorophenyl)ethanol
Synonyms
1-(3-Bromo-4-fluorophenyl);1-(3-BroMo-4-fluorophenyl)ethanol;1-(3-bromo-4-fluorophenyl)ethan-1-ol;3-bromo-4-fluoro-2-methylBenzenemethanol;Benzenemethanol, 3-bromo-4-fluoro-α-methyl-
CBNumber
CB22594509
Molecular Formula
C8H8BrFO
Formula Weight
219.05
MOL File
900175-01-1.mol
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B700940
Product name
1-(3-Bromo-4-fluorophenyl)ethanol
Packaging
500mg
Price
$90
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0069173
Product name
1-(3-BROMO-4-FLUOROPHENYL)ETHANOL
Purity
95.00%
Packaging
1G
Price
$199.5
Updated
2021/12/16
AK Scientific
Product number
4966AC
Product name
1-(3-Bromo-4-fluorophenyl)ethanol
Packaging
10g
Price
$533
Updated
2021/12/16
AK Scientific
Product number
4966AC
Product name
1-(3-Bromo-4-fluorophenyl)ethanol
Packaging
25g
Price
$1072
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0069173
Product name
1-(3-BROMO-4-FLUOROPHENYL)ETHANOL
Purity
95.00%
Packaging
5G
Price
$1206.98
Updated
2021/12/16
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1-(3-BroMo-4-fluorophenyl)ethanol Chemical Properties,Usage,Production

Synthesis

1007-15-4

900175-01-1

General procedure for the synthesis of 1-(3-bromo-4-fluorophenyl)ethanol from 1-(3-bromo-4-fluorophenyl)ethan-1-one: sodium borohydride (2.1 g, 55.5 mmol) was added batchwise to a mixture of 1-(3-bromo-4-fluorophenyl)ethan-1-one (10 g, 46 mmol) in a solution of tetrahydrofuran (THF, 100 mL) and methanol (1.0 mL) . The reaction mixture was heated to 70 °C and maintained for 1 h, followed by cooling to room temperature. Upon completion of the reaction, the reaction was quenched with 1N hydrochloric acid solution (100 mL) and extracted with ethyl acetate (EtOAc, 3 x 100 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 1-(3-bromo-4-fluorophenyl)ethanol (9.8 g, 97% yield).1H NMR (400 MHz, CDCl3) δppm: 1.48 (d, J=6.15 Hz, 3H), 7.24-7.33 (m, 1H), 7.59 (dd, J=6.59,2.20 Hz, 1H).

References

[1] Patent: WO2006/76246, 2006, A2. Location in patent: Page/Page column 155
[2] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 80
[3] Tetrahedron Letters, 2007, vol. 48, # 31, p. 5471 - 5474
[4] European Journal of Organic Chemistry, 2011, # 23, p. 4409 - 4414
[5] Patent: WO2018/81047, 2018, A1. Location in patent: Page/Page column 185

1-(3-BroMo-4-fluorophenyl)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-BroMo-4-fluorophenyl)ethanol Suppliers

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900175-01-1, 1-(3-BroMo-4-fluorophenyl)ethanolRelated Search:

Ethanol

  • 1-(3-BroMo-4-fluorophenyl)ethanol
  • 3-bromo-4-fluoro-2-methylBenzenemethanol
  • 1-(3-Bromo-4-fluorophenyl)
  • 1-(3-bromo-4-fluorophenyl)ethan-1-ol
  • Benzenemethanol, 3-bromo-4-fluoro-α-methyl-
  • 900175-01-1