5-bromo-4-fluoro-1H-indazole

Product Name: 5-bromo-4-fluoro-1H-indazole
CAS No.: 1082041-85-7
Chemical Name: 5-bromo-4-fluoro-1H-indazole
Synonyms: Orforglipron Impurity 6;Orforglipron impurity 31;5-Bromo-4-fluoro-Indazole;5-bromo-4-fluoro-1H-indazole;1H-Indazole,5-broMo-4-fluoro-
CBNumber: CB22594615
Molecular Formula: C7H4BrFN2
Formula Weight: 215.02
MOL File: 1082041-85-7.mol

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5-bromo-4-fluoro-1H-indazole Property

Boiling point:: 332.2±22.0 °C(Predicted)
Density: 1.861±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 11.95±0.40(Predicted)
form: solid
color: Off-white to brown
InChI: InChI=1S/C7H4BrFN2/c8-5-1-2-6-4(7(5)9)3-10-11-6/h1-3H,(H,10,11)
InChIKey: YJOQUFUSNSCGHN-UHFFFAOYSA-N
SMILES: N1C2=C(C(F)=C(Br)C=C2)C=N1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: B803483
Product name: 5-Bromo-4-fluoro-1H-indazole
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B803483
Product name: 5-Bromo-4-fluoro-1H-indazole
Packaging: 100mg
Price: $240
Updated: 2021/12/16

Apolloscientific

Product number: PC500202
Product name: 5-Bromo-4-fluoro-1H-indazole
Purity: 95%
Packaging: 5g
Price: $289
Updated: 2021/12/16

Apolloscientific

Product number: PC500202
Product name: 5-Bromo-4-fluoro-1H-indazole
Purity: 95%
Packaging: 250mg
Price: $62
Updated: 2021/12/16

Apolloscientific

Product number: PC500202
Product name: 5-Bromo-4-fluoro-1H-indazole
Purity: 95%
Packaging: 1g
Price: $97
Updated: 2021/12/16

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5-bromo-4-fluoro-1H-indazole Chemical Properties,Usage,Production

Uses

5-Bromo-4-fluoro-1H-indazole is a chemical intermediate that can be used to synthesize 3-fluoro-2-methylaniline.

Preparation

5-bromo-4-fluoro-1H-indazole can be obtained by the bromination of 4,5-dichloroindazole with NBS as a reagent.

Synthesis

127408-03-1

1082041-85-7

General procedure for the synthesis of 5-bromo-4-fluoro-1H-indazole from 4-bromo-3-fluoro-2-methylaniline: to a stirred solution of 4-bromo-3-fluoro-2-methylaniline (15.0 g, 73.5 mmol) in acetic acid (200 mL) was added sodium nitrite (10 g, 147 mmol) in batches at 10 °C. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, a 50% aqueous NaOH solution was added dropwise to the reaction mixture under vigorous stirring at -10 °C until the pH reached 7-8. Subsequently, the mixture was extracted with ethyl acetate. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: 0-40% hexane solution of ethyl acetate) to afford 5-bromo-4-fluoro-1H-indazole (10 g, 63% yield) as an off-white solid.LCMS retention time was 3.03 min and the molecular ion peak MH+ 214.1H NMR (400 MHz, CDCl3) δ 10.44 (broad single peak, 1H), δ 8.14 (single peak, 1H), 7.49-7.45 (multiple peaks, 1H), 7.19 (double peak, J = 8.76Hz, 1H).

References

[1] Patent: WO2018/130853, 2018, A1. Location in patent: Page/Page column 26
[2] Patent: US2012/71535, 2012, A1. Location in patent: Page/Page column 51
[3] Patent: WO2013/142266, 2013, A1. Location in patent: Paragraph 00487
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5129 - 5140
[5] Patent: US2016/347717, 2016, A1. Location in patent: Page/Page column 0293; 0294

5-bromo-4-fluoro-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-bromo-4-fluoro-1H-indazole Suppliers

China 133 India 1 United Kingdom 1 United States 8 Global 143

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View Lastest Price from 5-bromo-4-fluoro-1H-indazole manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-bromo-4-fluoro-1H-indazole 1082041-85-7
Price: US $0.00-0.00/KG
Min. Order: 5mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-06

Career Henan Chemical Co

Product: 1H-Indazole,5-broMo-4-fluoro- 1082041-85-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 200kgs
Release date: 2020-01-16

1082041-85-7, 5-bromo-4-fluoro-1H-indazoleRelated Search:

4-Fluorobenzyl bromide α-Bromo-2，3，4，5，6-pentafluorotoluene (S,E)-1-(4-fluoro-1-methyl-1H-indazol-5-yl)-3-(2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-1-(2-hydroxyvinyl)urea \\ 5-[(S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl]-1-[(1S,2S)-2-methyl-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclopropyl]-1H-indole-2-carboxylic Acid 1H-Indole-2-carboxamide, N-methyl-N-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-

1H-Indazole,5-broMo-4-fluoro-

5-bromo-4-fluoro-1H-indazole

5-Bromo-4-fluoro-Indazole

Orforglipron Impurity 6

Orforglipron impurity 31

1082041-85-7

108204-85-7