4-Fluorobenzyl bromide

Chemical Properties Uses

Product Name: 4-Fluorobenzyl bromide
CAS No.: 459-46-1
Chemical Name: 4-Fluorobenzyl bromide
Synonyms: 1-(BROMOMETHYL)-4-FLUOROBENZENE;Of fluoride broMide;4-Fluorobenzyl bromi;P-FLUOROBENZYL BROMIDE;4-FLUOROBENZYL BROMIDE;α-Bromo-4-fluorotoluene;1-bromo-3-fluorotoluene;à-bromo-4-fluorotoluene;4-FLUOROBBENZYL BROMIDE;A-BROMO-4-FLUOROTOLUENE
CBNumber: CB3471414
Molecular Formula: C7H6BrF
Formula Weight: 189.02
MOL File: 459-46-1.mol

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4-Fluorobenzyl bromide Property

Boiling point:: 85 °C15 mm Hg(lit.)
Density: 1.517 g/mL at 25 °C(lit.)
refractive index: n20/D 1.547(lit.)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Chloroform
form: Liquid
Specific Gravity: 1.517
color: Clear colorless to yellow
Sensitive: Lachrymatory
BRN: 636507
InChIKey: NVNPLEPBDPJYRZ-UHFFFAOYSA-N
CAS DataBase Reference: 459-46-1(CAS DataBase Reference)
NIST Chemistry Reference: «alpha»-Bromo-4-fluorotoluene(459-46-1)
EPA Substance Registry System: 4-Fluorobenzyl bromide (459-46-1)

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Safety

Hazard Codes: C
Risk Statements: 34-36
Safety Statements: 26-36/37/39-45
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive/Lachrymatory
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 209538
Product name: 4-Fluorobenzyl bromide
Purity: 97%
Packaging: 5g
Price: $42.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 209538
Product name: 4-Fluorobenzyl bromide
Purity: 97%
Packaging: 25g
Price: $114
Updated: 2025/07/31

TCI Chemical

Product number: F0214
Product name: 4-Fluorobenzyl Bromide
Purity: >97.0%(GC)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: F0214
Product name: 4-Fluorobenzyl Bromide
Purity: >97.0%(GC)
Packaging: 25g
Price: $86
Updated: 2025/07/31

TRC

Product number: F588610
Product name: 4-Fluorobenzyl Bromide
Packaging: 250g
Price: $720
Updated: 2021/12/16

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4-Fluorobenzyl bromide Chemical Properties,Usage,Production

Chemical Properties

4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.

Uses

4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.

Chemical Properties

Colorless to light yellow liqui

Uses

4-Fluorobenzyl bromide was used in the preparation of:

3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole
1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin
(S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin
8-bromo 9-(4-fluorobenzyl) adenine
8-bromo 3-(4-fluorobenzyl) adenine

Uses

4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.

Synthesis

459-56-3

459-46-1

GENERAL METHOD: Benzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL), phosphorus tribromide (0.5 mL) was added and the reaction was stirred at room temperature. Upon completion of the reaction, the target product 4-fluorobenzyl bromide was obtained in quantitative yield by conventional post-processing steps.

References

[1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344
[2] Bulletin of the Chemical Society of Ethiopia, 2012, vol. 26, # 2, p. 305 - 309
[3] Tetrahedron Letters, 2016, vol. 57, # 22, p. 2430 - 2433
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 2989 - 3002
[5] Chem, 2018, vol. 4, # 1, p. 124 - 137

4-Fluorobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluorobenzyl bromide Suppliers

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View Lastest Price from 4-Fluorobenzyl bromide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Fluorobenzyl Bromide 459-46-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-11

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Fluorobenzyl bromide 459-46-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-22

Henan Fengda Chemical Co., Ltd

Product: 4-Fluorobenzyl bromide 459-46-1
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

459-46-1, 4-Fluorobenzyl bromideRelated Search:

Rocuronium bromide [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-pro p-1-enyl-cyclopropane-1-carboxylate Diethylstilbestrol Ethyl bromodifluoroacetate Fluorobenzene Ethidium bromide 4-Fluorobenzyl chloride BRETYLIUM TOSYLATE Allyl bromide Sodium bromate alpha-Chloro-o-fluorotoluene 4-n-Propoxyphenylacetylene Bromine 1,2-Bis(bromomethyl)benzene 9-BROMOFLUORENE 2-(Trifluoromethyl)benzyl bromide 1,2,4,5-TETRAKIS(BROMOMETHYL)BENZENE Methyl bromide

P-FLUOROBENZYL BROMIDE

4-Fluoro-1-(bromomethyl)benzene

α-Bromo-4-fluorotoluene

4-Fluorobenzyl bromi

BroMobenzene of fluoride

Of fluoride broMide

1-(Bromomethyl)-4-fluorobenzene, alpha-Bromo-4-fluorotoluene

Toluene, α-broMo-p-fluoro- (6CI,7CI,8CI)

The fluorine broMine benzyl

ALPHA-BROMO-P-FLUOROTOLUENE

ALPHA-BROMO-4-FLUOROTOLUENE

4-FLUOROBENZYL BROMIDE

1-(BROMOMETHYL)-4-FLUOROBENZENE

1-(bromomethyl)-4-fluoro-benzen

Benzene, 1-(bromomethyl)-4-fluoro-

Toluene, alpha-bromo-p-fluoro-

4-fluoro(bromomethyl)benzene

1-bromo-3-fluorotoluene

à-bromo-4-fluorotoluene

4-Fluorobenzyl bromide 90%

4-Fluorobenzyl Bromide p-Fluorobenzyl Bromide

4-FLUOROBENZYL BROMIDE 98% (GC)

4-Fluorobenzylbromide,97%

α-Bromo-4-fluorotoluene, 1-Bromomethyl-4-fluorobenzene

4-Fluorobenzyl bromide ,98%

4-FLUOROBBENZYL BROMIDE

A-BROMO-4-FLUOROTOLUENE

4-FluorobenzylBromide&gt

4-Fluorobenzyl bromide, 98%, for synthesis

4-Fluorobenzyl bromide ISO 9001：2015 REACH

α-Bromo-p-fluorotoluene

459-46-1

BENZYL HALIDE

Building Blocks

Aryl

C7

Halogenated Hydrocarbons

Organic Building Blocks

Benzyl

Fluoro-contained benzyl bromide series

alkyl bromide|alkyl Fluorine

Halogenated Heterocycles ,Pyrimidines

Fluorinated benzene series

bc0001