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4-Fluorobenzyl chloride

Product Name
4-Fluorobenzyl chloride
CAS No.
352-11-4
Chemical Name
4-Fluorobenzyl chloride
Synonyms
JACS-352-11-4;Benzyl for CFCs;AKOS BBS-00003856;p-Fluorbenzylchlorid;alpha-Chloro-p-fluor;Fluorobenzyl chlorid;p-fluorochlorobenzyl;P-FLUOROBENZYL CHLORIDE;4-FLUOROBENZYL CHLORIDE;-Chloro-p-fluorotoluene
CBNumber
CB7166866
Molecular Formula
C7H6ClF
Formula Weight
144.57
MOL File
352-11-4.mol
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4-Fluorobenzyl chloride Property

Melting point:
-18 °C
Boiling point:
82 °C26 mm Hg(lit.)
Density 
1.207 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.513(lit.)
Flash point:
141 °F
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly), Hexanes (Slightly)
form 
Powder or Crystals
Specific Gravity
1.207
color 
Yellow
explosive limit
1.30%(V)
Water Solubility 
417mg/L(temperature not stated)
Sensitive 
Lachrymatory
BRN 
742272
InChI
1S/C7H6ClF/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2
InChIKey
IZXWCDITFDNEBY-UHFFFAOYSA-N
SMILES
Fc1ccc(CCl)cc1
CAS DataBase Reference
352-11-4(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-(chloromethyl)-4-fluoro-(352-11-4)
EPA Substance Registry System
Benzene, 1-(chloromethyl)-4-fluoro- (352-11-4)
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Safety

Hazard Codes 
C
Risk Statements 
34-22
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2920 8/PG 2
WGK Germany 
2
19
Hazard Note 
Corrosive/Lachrymatory
TSCA 
TSCA listed
HazardClass 
8
PackingGroup 
III
HS Code 
29036990
Storage Class
8A - Combustible corrosive hazardous materials
Hazard Classifications
Skin Corr. 1B
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F8004
Product name
4-Fluorobenzyl chloride
Purity
99%
Packaging
25g
Price
$42.5
Updated
2025/07/31
Sigma-Aldrich
Product number
F8004
Product name
4-Fluorobenzyl chloride
Purity
99%
Packaging
100g
Price
$69.6
Updated
2025/07/31
TCI Chemical
Product number
F0204
Product name
4-Fluorobenzyl Chloride
Purity
>98.0%(GC)
Packaging
25g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
F0204
Product name
4-Fluorobenzyl Chloride
Purity
>98.0%(GC)
Packaging
500g
Price
$374
Updated
2025/07/31
TRC
Product number
F588360
Product name
p-FluorobenzylChloride
Packaging
10g
Price
$110
Updated
2021/12/16
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4-Fluorobenzyl chloride Chemical Properties,Usage,Production

Chemical Properties

clear colorless to slightly yellow liquid

Uses

p-Fluorobenzyl Chloride is a chemical intermediate in the synthesis of various pharmaceutical and agricultural goods.

Synthesis

Photocatalyst: nanosilver/silver chloride surface plasma composite;
Substrate: p-fluorotoluene; Halogenator: potassium chloride;
(1) 50 ml of water, 7 g of sodium chloride and 2.5 ml of hydrochloric acid (mass fraction 35%) were added in a photocatalytic reactor, respectively, and dissolved with stirring;
(2) then add 0.3 g of nanosilver/silver chloride as a photocatalyst (nanosilver loading 8.5 mol%) and 0.05 g of tetrabutylammonium chloride as a phase-transfer catalyst, and finally add 15 ml of p-fluorotoluene; the loading is the molar amount of nanoprecious metals as a molar percentage of the total amount of nanoprecious metal/semiconductor surface plasmonic composite.
(3) Under strong magnetic stirring, then turn on 300W xenon lamp irradiation, and react for 5h at room temperature;
(4) Filtering to recover the catalyst, separating out the organic phase and recycling the aqueous phase for reuse. Samples were analyzed by GS, the conversion rate of p-fluorotoluene was 36%, and no polychlorinated products were detected. Distillation to collect 180.5-182 fraction, got 4-fluorobenzyl chloride, yield 89%.

4-Fluorobenzyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluorobenzyl chloride Suppliers

Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.
Tel
13396369453 QQ3007939906 18678026865
Fax
0536-2101172
Email
sdfantai@163.com
Country
China
ProdList
908
Advantage
58
Weifang Siyuan Chemical Co., Ltd.
Tel
0536-8888106 17663601818
Fax
0536-8888106
Email
2354379876@qq.com
Country
China
ProdList
245
Advantage
58
Weifang Weimeng Chemical Co., Ltd.
Tel
QQ 1340191485 15105445095
Email
weimengchem@163.com
Country
China
ProdList
485
Advantage
58
Hubei Hanqing Biopharmaceutical Technology Co., Ltd
Tel
15827429330
Email
3583890861@qq.com
Country
China
ProdList
4984
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Danyang Wanlong Chemical Co., Ltd
Tel
86-511-8681 0993
Fax
0511-86810666
Email
jeff@wanlongchem.com
Country
China
ProdList
63
Advantage
55
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
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View Lastest Price from 4-Fluorobenzyl chloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Fluorobenzyl chloride 352-11-4
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Hebei Yanxi Chemical Co., Ltd.
Product
4-Fluorobenzyl chloride 352-11-4
Price
US $15.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-10-25
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Fluorobenzyl chloride 352-11-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-19

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