Chemical Properties Uses
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4-Fluorobenzyl bromide

Chemical Properties Uses
Product Name
4-Fluorobenzyl bromide
CAS No.
459-46-1
Chemical Name
4-Fluorobenzyl bromide
Synonyms
1-(BROMOMETHYL)-4-FLUOROBENZENE;Of fluoride broMide;4-Fluorobenzyl bromi;P-FLUOROBENZYL BROMIDE;4-FLUOROBENZYL BROMIDE;α-BroMo-p-fluorotoluene;α-Bromo-4-fluorotoluene;1-bromo-3-fluorotoluene;à-bromo-4-fluorotoluene;4-FLUOROBBENZYL BROMIDE
CBNumber
CB3471414
Molecular Formula
C7H6BrF
Formula Weight
189.02
MOL File
459-46-1.mol
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4-Fluorobenzyl bromide Property

Boiling point:
85 °C15 mm Hg(lit.)
Density 
1.517 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.547(lit.)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
soluble in Chloroform
form 
Liquid
Specific Gravity
1.517
color 
Clear colorless to yellow
Sensitive 
Lachrymatory
BRN 
636507
InChIKey
NVNPLEPBDPJYRZ-UHFFFAOYSA-N
CAS DataBase Reference
459-46-1(CAS DataBase Reference)
NIST Chemistry Reference
«alpha»-Bromo-4-fluorotoluene(459-46-1)
EPA Substance Registry System
4-Fluorobenzyl bromide (459-46-1)
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Safety

Hazard Codes 
C
Risk Statements 
34-36
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
Hazard Note 
Corrosive/Lachrymatory
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
209538
Product name
4-Fluorobenzyl bromide
Purity
97%
Packaging
5g
Price
$41.4
Updated
2024/03/01
Sigma-Aldrich
Product number
209538
Product name
4-Fluorobenzyl bromide
Purity
97%
Packaging
25g
Price
$111
Updated
2024/03/01
TCI Chemical
Product number
F0214
Product name
4-Fluorobenzyl Bromide
Purity
>97.0%(GC)
Packaging
5g
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
F0214
Product name
4-Fluorobenzyl Bromide
Purity
>97.0%(GC)
Packaging
25g
Price
$90
Updated
2024/03/01
Alfa Aesar
Product number
A10208
Product name
4-Fluorobenzyl bromide, 97%
Packaging
10g
Price
$45.65
Updated
2024/03/01
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4-Fluorobenzyl bromide Chemical Properties,Usage,Production

Chemical Properties

4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.

Uses

4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.

Chemical Properties

Colorless to light yellow liqui

Uses

4-Fluorobenzyl bromide was used in the preparation of:

  • 3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole
  • 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin
  • (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin
  • 8-bromo 9-(4-fluorobenzyl) adenine
  • 8-bromo 3-(4-fluorobenzyl) adenine

Uses

4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.

4-Fluorobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluorobenzyl bromide Suppliers

Americas 1 Belgium 4 Canada 2 China 299 Europe 4 France 2 Germany 7 India 21 Israel 1 Italy 1 Japan 4 Slovakia 1 Switzerland 2 Ukraine 1 United Kingdom 16 United States 47 Global 413
Ricci Chimica
Tel
--
Fax
--
Email
sales@riccichimica.com
Country
Italy
ProdList
2146
Advantage
46
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View Lastest Price from 4-Fluorobenzyl bromide manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
4-Fluorobenzyl Bromide 459-46-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Fluorobenzyl bromide 459-46-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-22
Henan Fengda Chemical Co., Ltd
Product
4-Fluorobenzyl bromide 459-46-1
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25

459-46-1, 4-Fluorobenzyl bromideRelated Search:

Rocuronium bromide [2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl]methyl 2,2-dimethyl-3-pro p-1-enyl-cyclopropane-1-carboxylate Diethylstilbestrol Ethyl bromodifluoroacetate Fluorobenzene Ethidium bromide 4-Fluorobenzyl chloride BRETYLIUM TOSYLATE Allyl bromide Sodium bromate alpha-Chloro-o-fluorotoluene 4-n-Propoxyphenylacetylene Bromine 1,2-Bis(bromomethyl)benzene 9-BROMOFLUORENE 2-(Trifluoromethyl)benzyl bromide 1,2,4,5-TETRAKIS(BROMOMETHYL)BENZENE Methyl bromide

  • P-FLUOROBENZYL BROMIDE
  • 4-Fluoro-1-(bromomethyl)benzene
  • α-Bromo-4-fluorotoluene
  • 4-Fluorobenzyl bromi
  • BroMobenzene of fluoride
  • Of fluoride broMide
  • 1-(Bromomethyl)-4-fluorobenzene, alpha-Bromo-4-fluorotoluene
  • α-BroMo-p-fluorotoluene
  • Toluene, α-broMo-p-fluoro- (6CI,7CI,8CI)
  • The fluorine broMine benzyl
  • ALPHA-BROMO-P-FLUOROTOLUENE
  • ALPHA-BROMO-4-FLUOROTOLUENE
  • 4-FLUOROBENZYL BROMIDE
  • 1-(BROMOMETHYL)-4-FLUOROBENZENE
  • 1-(bromomethyl)-4-fluoro-benzen
  • Benzene, 1-(bromomethyl)-4-fluoro-
  • Toluene, alpha-bromo-p-fluoro-
  • 4-fluoro(bromomethyl)benzene
  • 1-bromo-3-fluorotoluene
  • à-bromo-4-fluorotoluene
  • 4-Fluorobenzyl bromide 90%
  • 4-Fluorobenzyl Bromide p-Fluorobenzyl Bromide
  • 4-FLUOROBENZYL BROMIDE 98% (GC)
  • 4-Fluorobenzylbromide,97%
  • α-Bromo-4-fluorotoluene, 1-Bromomethyl-4-fluorobenzene
  • 4-Fluorobenzyl bromide ,98%
  • 4-FLUOROBBENZYL BROMIDE
  • A-BROMO-4-FLUOROTOLUENE
  • 4-FluorobenzylBromide&gt
  • 4-Fluorobenzyl bromide, 98%, for synthesis
  • 4-Fluorobenzyl bromide ISO 9001：2015 REACH
  • α-Bromo-p-fluorotoluene
  • 459-46-1
  • BENZYL HALIDE
  • Building Blocks
  • Aryl
  • C7
  • Halogenated Hydrocarbons
  • Organic Building Blocks
  • Benzyl
  • Fluoro-contained benzyl bromide series
  • alkyl bromide|alkyl Fluorine
  • Halogenated Heterocycles ,Pyrimidines
  • Fluorinated benzene series
  • bc0001