ChemicalBook > CAS DataBase List > 4-Fluorobenzyl bromide
4-Fluorobenzyl bromide
Chemical Properties Uses- Product Name
- 4-Fluorobenzyl bromide
- CAS No.
- 459-46-1
- Chemical Name
- 4-Fluorobenzyl bromide
- Synonyms
- 1-(BROMOMETHYL)-4-FLUOROBENZENE;Of fluoride broMide;4-Fluorobenzyl bromi;P-FLUOROBENZYL BROMIDE;4-FLUOROBENZYL BROMIDE;α-Bromo-4-fluorotoluene;1-bromo-3-fluorotoluene;à-bromo-4-fluorotoluene;4-FLUOROBBENZYL BROMIDE;A-BROMO-4-FLUOROTOLUENE
- CBNumber
- CB3471414
- Molecular Formula
- C7H6BrF
- Formula Weight
- 189.02
- MOL File
- 459-46-1.mol
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4-Fluorobenzyl bromide Property
- Boiling point:
- 85 °C15 mm Hg(lit.)
- Density
- 1.517 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.547(lit.)
- Flash point:
- >230 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Chloroform
- form
- Liquid
- Specific Gravity
- 1.517
- color
- Clear colorless to yellow
- Sensitive
- Lachrymatory
- BRN
- 636507
- InChIKey
- NVNPLEPBDPJYRZ-UHFFFAOYSA-N
- CAS DataBase Reference
- 459-46-1(CAS DataBase Reference)
- NIST Chemistry Reference
- «alpha»-Bromo-4-fluorotoluene(459-46-1)
- EPA Substance Registry System
- 4-Fluorobenzyl bromide (459-46-1)
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Safety
- Hazard Codes
- C
- Risk Statements
- 34-36
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- Hazard Note
- Corrosive/Lachrymatory
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29039990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 209538
- Product name
- 4-Fluorobenzyl bromide
- Purity
- 97%
- Packaging
- 5g
- Price
- $42.7
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 209538
- Product name
- 4-Fluorobenzyl bromide
- Purity
- 97%
- Packaging
- 25g
- Price
- $114
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0214
- Product name
- 4-Fluorobenzyl Bromide
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $31
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0214
- Product name
- 4-Fluorobenzyl Bromide
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $86
- Updated
- 2025/07/31
TRC
- Product number
- F588610
- Product name
- 4-Fluorobenzyl Bromide
- Packaging
- 250g
- Price
- $720
- Updated
- 2021/12/16
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4-Fluorobenzyl bromide Chemical Properties,Usage,Production
Chemical Properties
4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.
Uses
4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.
Chemical Properties
Colorless to light yellow liqui
Uses
4-Fluorobenzyl bromide was used in the preparation of:
- 3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole
- 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin
- (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin
- 8-bromo 9-(4-fluorobenzyl) adenine
- 8-bromo 3-(4-fluorobenzyl) adenine
Uses
4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.
Synthesis
459-56-3
459-46-1
GENERAL METHOD: Benzyl alcohol (1 mmol) was dissolved in anhydrous benzene (15 mL), phosphorus tribromide (0.5 mL) was added and the reaction was stirred at room temperature. Upon completion of the reaction, the target product 4-fluorobenzyl bromide was obtained in quantitative yield by conventional post-processing steps.
References
[1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344
[2] Bulletin of the Chemical Society of Ethiopia, 2012, vol. 26, # 2, p. 305 - 309
[3] Tetrahedron Letters, 2016, vol. 57, # 22, p. 2430 - 2433
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 2989 - 3002
[5] Chem, 2018, vol. 4, # 1, p. 124 - 137
4-Fluorobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluorobenzyl bromide manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 4-Fluorobenzyl Bromide 459-46-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-11
Hebei Chuanghai Biotechnology Co,.LTD
- Product
- 4-Fluorobenzyl bromide 459-46-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99.%
- Supply Ability
- 10 ton
- Release date
- 2024-08-22
Henan Fengda Chemical Co., Ltd
- Product
- 4-Fluorobenzyl bromide 459-46-1
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
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