N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide
- Product Name
- N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide
- CAS No.
- 156353-01-4
- Chemical Name
- N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide
- Synonyms
- N-methoxy-N-methyloxane-4-carboxamide;N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide;tert-butyl 3-allyl-3-hydroxyazetidine-11-carboxylate;2H-Pyran-4-carboxamide, tetrahydro-N-methoxy-N-methyl-;Tetrahydro-pyran-4-carboxylic acid methoxy-methyl-amide
- CBNumber
- CB22597429
- Molecular Formula
- C8H15NO3
- Formula Weight
- 173.21
- MOL File
- 156353-01-4.mol
N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide Property
- Boiling point:
- 234.9±50.0 °C(Predicted)
- Density
- 1.090±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M341683
- Product name
- N-Methoxy-N-methyltetrahydropyran-4-carboxamide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M341683
- Product name
- N-Methoxy-N-methyltetrahydropyran-4-carboxamide
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- CS-0037535
- Product name
- N-Methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
- Product number
- 116000
- Product name
- N-Methoxy-N-methyltetrahydropyran-4-carboxamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $224
- Updated
- 2021/12/16
- Product number
- 116000
- Product name
- N-Methoxy-N-methyltetrahydropyran-4-carboxamide
- Purity
- 95%
- Packaging
- 5g
- Price
- $840
- Updated
- 2021/12/16
N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide Chemical Properties,Usage,Production
Synthesis
110238-91-0
6638-79-5
156353-01-4
1. Methyl tetrahydropyran-4-carboxylate (1.33 mL, 10.0 mmol) was dissolved in anhydrous THF (20 mL), N,O-dimethylhydroxylamine hydrochloride (1.51 g, 15.5 mmol) was added, and mixed with stirring. 2. Under argon protection, the reaction system was cooled to -30 °C, THF solution of isopropylmagnesium chloride (2.0 mol/L, 15.0 mL, 30.0 mmol) was slowly added dropwise, and the reaction was stirred for 1 hour keeping the temperature at -5 °C. The reaction was then stirred for 1 hour. 3. After completion of the reaction, the reaction was quenched by adding water to the mixture and the organic phase was extracted with ethyl acetate. 4. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. 5. The crude product was purified by distillation under reduced pressure to afford N-methoxy-N-methyltetrahydropyran-4-carboxamide (1.00 g, 58% yield). 6. The product was characterized as follows: boiling point 125-129 °C/8.0 hPa; 1H NMR (CDCl3, δ ppm): 1.57-1.66 (m, 2H), 1.77-1.93 (m, 2H), 2.85-2.94 (m, 1H), 3.18 (s, 3H), 3.44 (ddd, J = 2.4, 11.9, 11.9 Hz, 2H), 3.69 (s, 2H), 3.44 (ddd, J = 2.4, 11.9, 11.9 Hz, 2H). 2H), 3.69 (s, 3H), 4.00 (ddd, J = 2.4, 11.9, 11.9 Hz, 2H).
References
[1] Patent: WO2007/15528, 2007, A1. Location in patent: Page/Page column 230
[2] Patent: EP1894930, 2008, A1. Location in patent: Page/Page column 31
[3] Patent: EP1921077, 2017, B1. Location in patent: Paragraph 0742
[4] MedChemComm, 2016, vol. 7, # 5, p. 1016 - 1021
[5] Patent: WO2011/50016, 2011, A1. Location in patent: Page/Page column 99-100
N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide manufacturers
- Product
- N-Methoxy-N-methyltetrahydropyran-4-carboxamide 156353-01-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-09