N-METHOXY-N-METHYLTRIFLUOROACETAMIDE

Product Name: N-METHOXY-N-METHYLTRIFLUOROACETAMIDE
CAS No.: 104863-67-4
Chemical Name: N-METHOXY-N-METHYLTRIFLUOROACETAMIDE
Synonyms: 2,2,2-trifluoro-N-Methoxy-N-MethylacetaMide;4-Methoxy-3-methylthiophenol;N-METHOXY-N-METHYLTRIFLUOROACETAMIDE;N-METHYL-N-METHOXYTRIFLUOROACETAMIDE;N-Methoxy-N-methyltrifluoroacetamide98%;N-Methoxy-N-methyltrifluoroacetamide 98%;N-METHOXY-N-METHYL-2,2,2-TRIFLUOROACETAMIDE;2,2,2-Trifluoro-N-methoxy-N-methylaetamdine;Acetamide, 2,2,2-trifluoro-N-methoxy-N-methyl-;N-Methoxy-N-methyl-2,2,2-trifluoroacetamide 98%
CBNumber: CB6695174
Molecular Formula: C4H6F3NO2
Formula Weight: 157.09
MOL File: 104863-67-4.mol

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N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Property

Boiling point:: 53 °C/30 mmHg (lit.)
Density: 1.299 g/mL at 25 °C (lit.)
refractive index: 1.3630 to 1.3670
Flash point:: 118 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light yellow
InChI: InChI=1S/C4H6F3NO2/c1-8(10-2)3(9)4(5,6)7/h1-2H3
InChIKey: JDBJZZTZYKUFFK-UHFFFAOYSA-N
SMILES: C(N(OC)C)(=O)C(F)(F)F
CAS DataBase Reference: 104863-67-4(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 10-25-36
Safety Statements: 16-26-45
RIDADR: UN 1992 3/PG 3
WGK Germany: 3
HazardClass: IRRITANT
PackingGroup: III
HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 644153
Product name: N-Methoxy-N-methyl-2,2,2-trifluoroacetamide
Purity: 98%
Packaging: 5ml
Price: $75.52
Updated: 2025/07/31

Sigma-Aldrich

Product number: 644153
Product name: N-Methoxy-N-methyl-2,2,2-trifluoroacetamide
Purity: 98%
Packaging: 25ml
Price: $232.4
Updated: 2025/07/31

TCI Chemical

Product number: T3326
Product name: 2,2,2-Trifluoro-N-methoxy-N-methylacetamide
Purity: >98.0%(GC)
Packaging: 5g
Price: $66
Updated: 2025/07/31

TCI Chemical

Product number: T3326
Product name: 2,2,2-Trifluoro-N-methoxy-N-methylacetamide
Purity: >98.0%(GC)
Packaging: 25g
Price: $198
Updated: 2025/07/31

TRC

Product number: M271688
Product name: N-Methoxy-N-methyltrifluoroacetamide
Packaging: 5g
Price: $75
Updated: 2021/12/16

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N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Synthesis

6638-79-5

407-25-0

104863-67-4

To a suspension of N,O-dimethylhydroxylamine hydrochloride (107.2 kg, 1.1 kmol) in dichloromethane (400 L) was sequentially added trifluoroacetic anhydride (210 kg, 1 kmol) and pyridine (174 kg, 2.2 kmol) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, the reaction solution was diluted with ice water (300 L) and washed with 2M hydrochloric acid (300 L). The aqueous phase was extracted twice with dichloromethane, the organic phases were combined and dried with anhydrous magnesium sulfate. After concentration of the organic phase, the crude N-methoxy-N-methyl-2,2,2-trifluoroacetamide (Weinreb amide) was obtained with 90% purity and 95% yield, which could be used in the subsequent reaction without further purification.

References

[1] Asian Journal of Chemistry, 2015, vol. 27, # 7, p. 2406 - 2408
[2] Journal of Organic Chemistry, 1991, vol. 56, # 13, p. 4260 - 4263
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7887 - 7896
[4] Patent: WO2003/101932, 2003, A2. Location in patent: Page 64
[5] Patent: WO2003/82787, 2003, A1. Location in patent: Page/Page column 108

N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Suppliers

China 128 France 1 Germany 2 India 6 Japan 1 Russia 1 Switzerland 1 United Kingdom 7 United States 17 Global 164

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View Lastest Price from N-METHOXY-N-METHYLTRIFLUOROACETAMIDE manufacturers

Career Henan Chemical Co

Product: N-METHOXY-N-METHYLTRIFLUOROACETAMIDE 104863-67-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-06

104863-67-4, N-METHOXY-N-METHYLTRIFLUOROACETAMIDERelated Search:

N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide N-Methyl-2,2,2-trifluoroacetamide N-METHYL-N-METHOXYDIFLUOROACETAMIDE N-METHOXY-N-METHYLTRIFLUOROACETAMIDE

N-METHYL-N-METHOXYTRIFLUOROACETAMIDE

N-METHOXY-N-METHYLTRIFLUOROACETAMIDE

N-METHOXY-N-METHYL-2,2,2-TRIFLUOROACETAMIDE

N-Methoxy-N-methyltrifluoroacetamide 98%

N-Methoxy-N-methyltrifluoroacetamide98%

4-Methoxy-3-methylthiophenol

N-Methoxy-N-methyl-2,2,2-trifluoroacetamide 98%

N-Methoxy-N-(trifluoroacetyl)methylamine, N-Methoxy-N-methyl-2,2,2-trifluoroacetamide

2,2,2-trifluoro-N-Methoxy-N-MethylacetaMide

N-Methoxy-N-methyl-2,2,2-trifluoroacetamide≥ 98%(GC)

N-Methoxy-N-(trifluoroacetyl)methylamine, N-Methoxy-N-methyl

Acetamide, 2,2,2-trifluoro-N-methoxy-N-methyl-

104863-67-4 C4H6F3NO2 N-METHOXY-N-METHYLTRIFLUOROACETAMIDE

<i>N</i>-Methoxy-<i>N</i>-methyl-2,2,2-trifluoroacetamide

2,2,2-Trifluoro-N-methoxy-N-methylaetamdine

104863-67-4

Carbonyl Compounds

Amides

Building Blocks

Organic Building Blocks