N-Methyl-2,2,2-trifluoroacetamide

Product Name: N-Methyl-2,2,2-trifluoroacetamide
CAS No.: 815-06-5
Chemical Name: N-Methyl-2,2,2-trifluoroacetamide
Synonyms: TIMTEC-BB SBB008211;N-Methyl-2,2,2-trifl;N-METHYLTRIFLUOROACETAMIDE;N-Methyltrifluoroacetamide>N-Methyltrifluoroacetamide,98%;N-Methyltrifluoroacetamide 98%;2,2,2-TRIFLUORO-N-METHYLACETAMIDE;2,2,2-trifluoro-n-methyl-acetamid;N-METHYL-2,2,2-TRIFLUOROACETAMIDE;N-metnyl-2,2,2-trifluoroacetamide
CBNumber: CB5448241
Molecular Formula: C3H4F3NO
Formula Weight: 127.07
MOL File: 815-06-5.mol

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N-Methyl-2,2,2-trifluoroacetamide Property

Melting point:: 49-51 °C(lit.)
Boiling point:: 156-157 °C(lit.)
Density: 1.3215 (estimate)
Flash point:: 165 °F
storage temp.: Inert atmosphere,Room Temperature
pka: 11.54±0.46(Predicted)
form: powder to crystal
color: White to Almost white
Sensitive: Hygroscopic
BRN: 1703392
InChI: InChI=1S/C3H4F3NO/c1-7-2(8)3(4,5)6/h1H3,(H,7,8)
InChIKey: IQNHBUQSOSYAJU-UHFFFAOYSA-N
SMILES: C(NC)(=O)C(F)(F)F
CAS DataBase Reference: 815-06-5(CAS DataBase Reference)
NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-N-methyl-(815-06-5)
EPA Substance Registry System: Acetamide, 2,2,2-trifluoro-N-methyl- (815-06-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
RIDADR: UN 1325 4.1/PG 2
WGK Germany: 3
F: 3-10-21
Hazard Note: Irritant/Hygroscopic
TSCA: T
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 242098
Product name: N-Methyltrifluoroacetamide
Purity: 98%
Packaging: 25g
Price: $112
Updated: 2025/07/31

TCI Chemical

Product number: M0817
Product name: N-Methyltrifluoroacetamide
Purity: >98.0%(GC)
Packaging: 25g
Price: $29
Updated: 2025/07/31

TRC

Product number: M330655
Product name: N-Methyltrifluoroacetamide
Packaging: 50g
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 283394
Product name: N-Methyl-2,2,2-trifluoroacetamide
Packaging: 10g
Price: $403
Updated: 2021/12/16

TRC

Product number: M330655
Product name: N-Methyltrifluoroacetamide
Packaging: 1g
Price: $65
Updated: 2021/12/16

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N-Methyl-2,2,2-trifluoroacetamide Chemical Properties,Usage,Production

Chemical Properties

WHITE CRYSTALS OR CRYSTALLINE POWDER

Uses

N-Methyltrifluoroacetamide is a useful synthetic intermediate. It is used to prepare electrophilic 11b-aryl derivs. of estradiol as steroidal affinity labels of the estrogen receptor a. It is also used to synthesize amino substituted derivatives of 5'-amino-5'-deoxy-5'-noraristeromycin as antiviral agent.

General Description

The high-resolution proton and fluorine resonance spectra of N-methyltrifluoroacetamide in tetrahydrofuran and acetone was studied.

Synthesis

354-38-1

815-06-5

Example 6-B: Trifluoroacetamide (300 mg; 0.63 mmol) was dissolved in THF (2 mL) at 0 °C, NaH (60% mineral oil dispersion, 50 mg; 0.63 mmol) was added, followed by dropwise addition of MeI (60 μL; 0.94 mmol). The reaction mixture was stirred overnight at room temperature. After completion of the reaction, THF was removed by evaporation and the residue was diluted with water and extracted with CH2Cl2. The organic layers were combined, washed with saturated brine and dried over anhydrous Na2SO4. After concentration, the crude product was purified by rapid chromatography on silica gel (eluent: hexane/ethyl acetate, gradient from 4:1 to 1:1) to afford N-methyl-2,2,2-trifluoroacetamide 200 mg in 65% yield.

References

[1] Patent: US2003/105094, 2003, A1

N-Methyl-2,2,2-trifluoroacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Methyl-2,2,2-trifluoroacetamide Suppliers

Americas 1 Austria 1 Belgium 1 China 149 Europe 1 Germany 3 India 5 Japan 2 Russia 1 Switzerland 2 United Kingdom 13 United States 25 Global 204

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View Lastest Price from N-Methyl-2,2,2-trifluoroacetamide manufacturers

Nanjing Deda New Material Technology Ltd.

Product: N-Methyl-2,2,2-trifluoroacetamide 815-06-5
Price: US $10.00-30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100ton/ month
Release date: 2024-03-29

Henan Fengda Chemical Co., Ltd

Product: N-Methyl-2,2,2-trifluoroacetamide 815-06-5
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Career Henan Chemical Co

Product: N-Methyl-2,2,2-trifluoroacetamide 815-06-5
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

815-06-5, N-Methyl-2,2,2-trifluoroacetamideRelated Search:

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N-METHYL-2,2,2-TRIFLUOROACETAMIDE

TIMTEC-BB SBB008211

2,2,2-trifluoro-n-methyl-acetamid

N-Methyltrifluoroacetamide,98%

N-Methyl-2,2,2-trifluoroacetamide 98%

N-metnyl-2,2,2-trifluoroacetamide

N-Methyl-2,2,2-trifluoroacetamide, 98+%

N-Methyl-2,2,2-trifl

N-Methyltrifluoroacetamide 98%

N-Methyl-2,2,2-trifluoroacetamide for synthesis

2,2,2-TRIFLUORO-N-METHYLACETAMIDE

N-METHYLTRIFLUOROACETAMIDE

N-Methyltrifluoroacetamide&gt

Acetamide, 2,2,2-trifluoro-N-methyl-

N-Methyl-2,2,2-trifluoroacetamide ISO 9001：2015 REACH

<i>N</i>-Methyltrifluoroacetamide

815-06-5

C3H4F3NO

C3F3H4NO

CF3CONHCH3

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