Trifluoroacetamide

Product Name: Trifluoroacetamide
CAS No.: 354-38-1
Chemical Name: Trifluoroacetamide
Synonyms: 2,2,2-TRIFLUOROACETAMIDE;Acetamide, 2,2,2-trifluoro-;CF3CONH2;Triflouroacetamide;Three-;TRIFLUOROACETAMIDE;2-TriflouroacetaMide;Three fluoroacetaMide;Trifluoroacetamide98%;2,2,2-Trifluoracetamid
CBNumber: CB0291820
Molecular Formula: C2H2F3NO
Formula Weight: 113.04
MOL File: 354-38-1.mol

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Trifluoroacetamide Property

Melting point:: 65-70 °C (lit.)
Boiling point:: 162.5 °C (lit.)
Density: 1.4176 (estimate)
bulk density: 960kg/m3
Flash point:: 162-164°C
storage temp.: Store below +30°C.
solubility: 460 g/L (20°C)
pka: 12.33±0.50(Predicted)
form: Crystalline Powder or Crystals
color: White to pale yellow or beige
PH: 3.6 (460g/l, H2O, 23℃)
Water Solubility: 460 g/L (20 ºC)
BRN: 1753625
InChIKey: NRKYWOKHZRQRJR-UHFFFAOYSA-N
LogP: 0.725 at 23℃ and pH4.83
Dissociation constant: 0 at 23℃
CAS DataBase Reference: 354-38-1(CAS DataBase Reference)
NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-(354-38-1)
EPA Substance Registry System: Acetamide, 2,2,2-trifluoro- (354-38-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
RIDADR: 1759
WGK Germany: 3
Hazard Note: Harmful/Irritant
TSCA: T
HazardClass: 8
PackingGroup: III
HS Code: 29241900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.14690
Product name: 2,2,2-Trifluoroacetamide
Purity: for synthesis
Packaging: 10G
Price: $38
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.14690
Product name: 2,2,2-Trifluoroacetamide
Purity: for synthesis
Packaging: 50G
Price: $104
Updated: 2025/07/31

Sigma-Aldrich

Product number: 144657
Product name: Trifluoroacetamide
Purity: 97%
Packaging: 25g
Price: $41.23
Updated: 2025/07/31

Sigma-Aldrich

Product number: 144657
Product name: Trifluoroacetamide
Purity: 97%
Packaging: 100g
Price: $108.3
Updated: 2025/07/31

TCI Chemical

Product number: T0598
Product name: Trifluoroacetamide
Purity: >98.0%(GC)
Packaging: 25g
Price: $20
Updated: 2025/07/31

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Trifluoroacetamide Chemical Properties,Usage,Production

Chemical Properties

white to pale yellow or beige crystalline powder

Uses

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

Application

Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies.

Preparation

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292

General Description

Trifluoroacetamide is a good quencher of tryptophan fluorescence.

Synthesis

383-63-1

354-38-1

Example 5: Synthesis of the blocking isomer trifluoroacetamide 3a The block trans isomer 2a (0.93 g, 1.84 mmol, 503.4 g/mol) as a sulfate was dissolved in 15 mL of ethanol. Under argon protection, triethylamine (1.8 mL, 13 mmol) and ethyl trifluoroacetate (2.2 mL, 18 mmol) were slowly added (Figure 2a). The reaction mixture was stirred for 2.5 h at room temperature. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure. The resulting residue was dissolved in 300 mL of ethyl acetate and washed sequentially with 2 x 50 mL of 5% hydrochloric acid solution. The organic phase was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford block-transfer isomerized trifluoroacetamide 3a as an orange solid (0.92 g, 100% yield, 501.4 g/mol). 1H NMR (methanol-d4) δ 8.35 (1H, d); 8.15 (1H, d); 7.80 (1H, s); 6.82 (1H, s); 6.65 (4H, m); 4.82 (2H, s).

References

[1] Patent: US6448407, 2002, B1
[2] Journal of the American Chemical Society, 1943, vol. 65, p. 1459
[3] Journal of the American Chemical Society, 1943, vol. 65, p. 1459
[4] Journal of Organic Chemistry, 1959, vol. 24, p. 1256,1258
[5] Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1922, vol. <5>8, p. 346

Trifluoroacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

5-(CHLOROMETHYL)-2-(TRIFLUOROMETHYL)THIAZOLE (2-(TRIFLUOROMETHYL)THIAZOL-5-YL)METHANOL 2-BROMO-1-(2-(TRIFLUOROMETHYL)THIAZOL-5-YL)ETHANONE ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE 2,2,2-TRIFLUOROETHYLAMINE 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBALDEHYDE

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Trifluoroacetamide Suppliers

Austria 1 Belgium 2 CHINA 390 Europe 4 France 1 Germany 7 India 19 Italy 1 Japan 6 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 16 United States 53 Global 506

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View Lastest Price from Trifluoroacetamide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Trifluoroacetamide 354-38-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-10

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Trifluoroacetamide 354-38-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-29

Henan Aochuang Chemical Co.,Ltd.

Product: Trifluoroacetamide 354-38-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

354-38-1, TrifluoroacetamideRelated Search:

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C2H2F3NO

CF3CONH3

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