ChemicalBook > CAS DataBase List > Trifluoroacetamide

Trifluoroacetamide

Product Name: Trifluoroacetamide
CAS No.: 354-38-1
Chemical Name: Trifluoroacetamide
Synonyms: 2,2,2-TRIFLUOROACETAMIDE;Acetamide, 2,2,2-trifluoro-;CF3CONH2;Triflouroacetamide;Three-;TRIFLUOROACETAMIDE;2-TriflouroacetaMide;Three fluoroacetaMide;Trifluoroacetamide98%;2,2,2-Trifluoracetamid
CBNumber: CB0291820
Molecular Formula: C2H2F3NO
Formula Weight: 113.04
MOL File: 354-38-1.mol

Less

Trifluoroacetamide Property

Melting point:: 65-70 °C (lit.)
Boiling point:: 162.5 °C (lit.)
Density: 1.4176 (estimate)
bulk density: 960kg/m3
Flash point:: 162-164°C
storage temp.: Store below +30°C.
solubility: 460 g/L (20°C)
pka: 12.33±0.50(Predicted)
form: Crystalline Powder or Crystals
color: White to pale yellow or beige
PH: 3.6 (460g/l, H2O, 23℃)
Water Solubility: 460 g/L (20 ºC)
BRN: 1753625
InChIKey: NRKYWOKHZRQRJR-UHFFFAOYSA-N
LogP: 0.725 at 23℃ and pH4.83
Dissociation constant: 0 at 23℃
CAS DataBase Reference: 354-38-1(CAS DataBase Reference)
NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-(354-38-1)
EPA Substance Registry System: Acetamide, 2,2,2-trifluoro- (354-38-1)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
RIDADR: 1759
WGK Germany: 3
Hazard Note: Harmful/Irritant
TSCA: T
HazardClass: 8
PackingGroup: III
HS Code: 29241900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.14690
Product name: 2,2,2-Trifluoroacetamide
Purity: for synthesis
Packaging: 10G
Price: $38
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.14690
Product name: 2,2,2-Trifluoroacetamide
Purity: for synthesis
Packaging: 50G
Price: $104
Updated: 2025/07/31

Sigma-Aldrich

Product number: 144657
Product name: Trifluoroacetamide
Purity: 97%
Packaging: 25g
Price: $41.23
Updated: 2025/07/31

Sigma-Aldrich

Product number: 144657
Product name: Trifluoroacetamide
Purity: 97%
Packaging: 100g
Price: $108.3
Updated: 2025/07/31

TCI Chemical

Product number: T0598
Product name: Trifluoroacetamide
Purity: >98.0%(GC)
Packaging: 25g
Price: $20
Updated: 2025/07/31

Less

Trifluoroacetamide Chemical Properties,Usage,Production

Chemical Properties

white to pale yellow or beige crystalline powder

Uses

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

Application

Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies.

Preparation

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292

General Description

Trifluoroacetamide is a good quencher of tryptophan fluorescence.

Synthesis

383-63-1

354-38-1

Example 5: Synthesis of the blocking isomer trifluoroacetamide 3a The block trans isomer 2a (0.93 g, 1.84 mmol, 503.4 g/mol) as a sulfate was dissolved in 15 mL of ethanol. Under argon protection, triethylamine (1.8 mL, 13 mmol) and ethyl trifluoroacetate (2.2 mL, 18 mmol) were slowly added (Figure 2a). The reaction mixture was stirred for 2.5 h at room temperature. Upon completion of the reaction, the volatiles were removed by distillation under reduced pressure. The resulting residue was dissolved in 300 mL of ethyl acetate and washed sequentially with 2 x 50 mL of 5% hydrochloric acid solution. The organic phase was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford block-transfer isomerized trifluoroacetamide 3a as an orange solid (0.92 g, 100% yield, 501.4 g/mol). 1H NMR (methanol-d4) δ 8.35 (1H, d); 8.15 (1H, d); 7.80 (1H, s); 6.82 (1H, s); 6.65 (4H, m); 4.82 (2H, s).

References

[1] Patent: US6448407, 2002, B1
[2] Journal of the American Chemical Society, 1943, vol. 65, p. 1459
[3] Journal of the American Chemical Society, 1943, vol. 65, p. 1459
[4] Journal of Organic Chemistry, 1959, vol. 24, p. 1256,1258
[5] Bulletin de la Classe des Sciences, Academie Royale de Belgique, 1922, vol. <5>8, p. 346

Trifluoroacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

5-(CHLOROMETHYL)-2-(TRIFLUOROMETHYL)THIAZOLE (2-(TRIFLUOROMETHYL)THIAZOL-5-YL)METHANOL 2-BROMO-1-(2-(TRIFLUOROMETHYL)THIAZOL-5-YL)ETHANONE ETHYL 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBOXYLATE 2,2,2-TRIFLUOROETHYLAMINE 2-(TRIFLUOROMETHYL)THIAZOLE-5-CARBALDEHYDE

Less

Trifluoroacetamide Suppliers

Austria 1 Belgium 2 CHINA 388 Europe 4 France 1 Germany 7 India 19 Italy 1 Japan 6 Russia 1 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 16 United States 53 Global 504

Jinan Wanxingda New Material Technology Co., Ltd.

Tel: 0531-88064106 18253116016
Email: zhangjia@wxdchem.com
Country: China
ProdList: 43
Advantage: 58

Jinan Fuzhe New Material Co., Ltd.

Tel: 00-15169181 15169181281
Email: 15169181281@163.com
Country: China
ProdList: 262
Advantage: 58

Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.

Tel: 13396369453 QQ3007939906 18678026865
Fax: 0536-2101172
Email: sdfantai@163.com
Country: China
ProdList: 906
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 021-68882955 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 4992
Advantage: 58

Shanghai Chang-Gen Chemical Technology Co., Ltd.

Tel: 021-69106814 13917161715
Email: 3007500651@qq.com
Country: China
ProdList: 80
Advantage: 60

Weifang Weimeng Chemical Co., Ltd.

Tel: QQ 1340191485 15105445095
Email: weimengchem@163.com
Country: China
ProdList: 482
Advantage: 58

SHANG FLUORO

Tel: 021-65170832 15601903708
Email: qinba_1@163.com
Country: China
ProdList: 399
Advantage: 60

jinanzhonglanhuagongyouxiangongsi

Tel: 15169176553; 15169176553
Email: 644658103@qq.com
Country: China
ProdList: 32
Advantage: 58

Jinan Grenda Medical Technology Co., Ltd.

Tel: 0531-13287705608 13287705608
Email: xiaoya198706@126.com
Country: China
ProdList: 278
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD

Tel: 571-89189769 15168342188
Fax: 0571-86205065
Country: China
ProdList: 229
Advantage: 62

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Nanjing Kaitian Chemical Co., Ltd.

Tel: +86 (25) 5860-8846
Fax: +86 (25) 5860-8846
Email: kt_chem@126.com
Country: China
ProdList: 218
Advantage: 62

Wuhan Kemi-Works Chemical Co., Ltd

Tel: 027-85736489
Fax: 86-27-85736485
Email: info@kemiworks.net
Country: China
ProdList: 540
Advantage: 57

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Beijing Taiya Jie Technology Development Co., Ltd.

Tel: 021-33690831-8001 13552411790
Fax: 021-33690831
Email: postmaster@tyjchem.cn
Country: China
ProdList: 1542
Advantage: 55

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd

Tel: 0576-88685096 13989620089
Fax: 0086-576-88685099
Email: sales@yfchem.cn
Country: China
ProdList: 9
Advantage: 65

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Anichem Inc.

Tel: 0512-69369885
Fax: 0512-69369880
Email: sales@anichem.com.cn
Country: China
ProdList: 495
Advantage: 55

Less

View Lastest Price from Trifluoroacetamide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Trifluoroacetamide 354-38-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-10

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Trifluoroacetamide 354-38-1
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-29

Henan Aochuang Chemical Co.,Ltd.

Product: Trifluoroacetamide 354-38-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

354-38-1, TrifluoroacetamideRelated Search:

N-6-Trifluoroacetyl-L-lysine Trifluoroacetamidine Methyl trifluoroacetate Potassium trifluoroacetate AMMONIUM TRIFLUOROACETATE THALLIUM(III) TRIFLUOROACETATE Silver trifluoroacetate Trifluoroacetophenone Trifluoroacetic acid Trifluoroacetic anhydride 3-TRIMETHYLSILYL-2-PROPYN-1-OL SULFUR TRIOXIDE TRIMETHYLAMINE COMPLEX Boron trifluoride tetrahydrofuran complex 2,2,2-Trifluoroethylamine hydrochloride Trifluoroacetonitrile 2,2,2-TRIFLUOROETHYLAMINE Methanesulfonic acid, 1,1,1-trifluoro-, 5-hydroxy-1-naphthalenyl ester Bis(trimethylsilyl)trifluoroacetamide

Three fluoroacetaMide

2,2,2-TRIFLUOROACETAMIDE

TRIFLUOROACETAMIDE

TRIFLUOROACETIC ACID AMIDE

2,2,2-trifluoro-acetamid

CF3CONH2

Triflouroacetamide

TRIFLUOROACETAMIDE 98%

Acetamide, 2,2,2-trifluoro-

2,2,2-TRIFLOUROACETAMIDE

2,2,2-TRIFLOUROACET-AMIDE (TFAA)

Trifluoroacetamide98%

2,2,2-TRIFLOUROACET-AMIDE TFAA 98+%

2,2,2-Trifluoroacetamide (TFAA)

2,2,2-Trifluoroacetamide ,99%

2,2,2-Trifluoroacetamide,97%

2,2,2-trifluoroacetanide

2-TriflouroacetaMide

2,2,2-TRIFLUOROACETAMIDE FOR SYNTHESIS

Three-

Factory Supply Trifluoroacetamid E CAS?354-38-1?with Best Price

2,2,4-Trifluoroacetamide, 97%+

2,2,4-Trifluoroacetamide

2,2,2-Trifluoracetamid

fantaichem.webd.testwebsite.cn

Trifluoroacetamide, 97%

354-38-1

C2H2F3NO

CF3CONH3

Organic Building Blocks

Carbonyl Compounds

Amides

Building Blocks

Amides

Carbonyl Compounds

Organic Building Blocks

top

bc0001