2,2,2-Trifluoroethylamine hydrochloride

Product Name: 2,2,2-Trifluoroethylamine hydrochloride
CAS No.: 373-88-6
Chemical Name: 2,2,2-Trifluoroethylamine hydrochloride
Synonyms: TAF;2,2,2-Trifluoroethanamine hydrochloride;TRIFLUOROETHYLAMINE HYDROCHLORIDE;2,2,2-Trifluoroethyla;2,2,2-TRIFLUORO-;2,2,2-TrifluoroethylamineHCl;2,2,2-Trifluoro-ethanamine HCl;trifluoro-ethylaminhydrochloride;2,2,2-Trifluoroaminehydrochloride;2,2,2-trifluoroethanaminium chloride
CBNumber: CB4396448
Molecular Formula: C2H5ClF3N
Formula Weight: 135.52
MOL File: 373-88-6.mol

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2,2,2-Trifluoroethylamine hydrochloride Property

Melting point:: 220-222 °C (subl.)(lit.)
Density: 1,24g/cm
refractive index: 1,3-1,302
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
color: White to Light yellow to Light orange
Water Solubility: It is Soluble in 0.7 to water, but soluble in ethanol and chloroform, slightly soluble in benzene, hardly soluble in ether.
Sensitive: Hygroscopic
BRN: 3652103
InChI: InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H
InChIKey: ZTUJDPKOHPKRMO-UHFFFAOYSA-N
SMILES: C(F)(F)(F)CN.Cl
CAS DataBase Reference: 373-88-6(CAS DataBase Reference)
EPA Substance Registry System: Ethanamine, 2,2,2-trifluoro-, hydrochloride (373-88-6)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 36/37-24/25-36-26
WGK Germany: 3
RTECS: KS0250000
F: 3-10-21
Hazard Note: Hygroscopic/Toxic
TSCA: T
HazardClass: IRRITANT
PackingGroup: III
HS Code: 29211990
Toxicity: LD50 unr-mus: 476 mg/kg 11FYAN 3,81,63

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 180386
Product name: 2,2,2-Trifluoroethylamine hydrochloride
Purity: 98%
Packaging: 10g
Price: $117.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 180386
Product name: 2,2,2-Trifluoroethylamine hydrochloride
Purity: 98%
Packaging: 50g
Price: $271.7
Updated: 2025/07/31

TCI Chemical

Product number: T1170
Product name: 2,2,2-Trifluoroethylamine Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 5g
Price: $25
Updated: 2025/07/31

TCI Chemical

Product number: T1170
Product name: 2,2,2-Trifluoroethylamine Hydrochloride
Purity: >98.0%(N)(T)
Packaging: 25g
Price: $64
Updated: 2025/07/31

TRC

Product number: T787295
Product name: 2,2,2-Trifluoroethylamine hydrochloride
Packaging: 5g
Price: $100
Updated: 2021/12/16

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2,2,2-Trifluoroethylamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE POWDER

Uses

2,2,2-Trifluoroethylamine Hydrochloride is a reagent in the synthesis of arachidonylethanolamide analogs. These show affinity for CB1 and CB2 cannabinoid receptors.

Safety Profile

Moderately toxic by unspecifiedroute. When heated to decomposition it emits very toxicfumes of F??, NOx, and HCl.

Synthesis

753-90-2

373-88-6

General procedure for the synthesis of 2,2,2-trifluoroethylamine hydrochloride from 2,2,2-trifluoroethylamine: 100 g of ethanol and 33 g of 2,2,2-trifluoroethylamine were added to a triple-necked flask, and 35 g of saturated hydrochloric acid solution was added slowly and dropwise at temperatures lower than 25°C. The reaction system was then brought up to 50°C and maintained there for 1 hour. After the dropwise addition, the temperature of the reaction system was raised to 50 °C and maintained for 1 hour. Subsequently, the temperature of the reaction solution was controlled to be 45±5°C under a vacuum of 0.98 MPa and a decompression distillation was carried out for 5 hours to remove water and ethanol. Finally 43.5 g of 2,2,2-trifluoroethylamine hydrochloride was obtained in 96.30% yield. The resulting product was a white powdery crystalline solid with 0.13% water.

References

[1] Patent: CN105801428, 2016, A. Location in patent: Paragraph 0016; 0017

2,2,2-Trifluoroethylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2,2-Trifluoroethylamine hydrochloride Suppliers

Belgium 3 Canada 1 CHINA 311 France 2 Germany 7 India 13 Japan 7 Russia 1 Slovakia 1 Switzerland 2 The Netherlands 2 United Kingdom 18 United States 44 Global 412

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View Lastest Price from 2,2,2-Trifluoroethylamine hydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,2,2-Trifluoroethylamine hydrochloride 373-88-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-11-26

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2,2,2-trifluoroethanaminium chloride 373-88-6
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-08

Hebei Fengjia New Material Co., Ltd

Product: 2,2,2-Trifluoroethylamine hydrochloride 373-88-6
Price: US $30.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100 tons
Release date: 2024-08-09

373-88-6, 2,2,2-Trifluoroethylamine hydrochlorideRelated Search:

Triethylamine hydrochloride Topotecan hydrochloride Triethylamine 2-Phenylethylamine hydrochloride Ethylamine hydrochloride Trimethylamine hydrochloride 2,2,2-TRIFLUOROETHYLAMINE Perfluorotriethylamine Trifluoroacetamide Trifluoroacetonitrile Methanesulfonic acid, 1,1,1-trifluoro-, 5-hydroxy-1-naphthalenyl ester 2-AMINO-4,4,4-TRIFLUORO-N-BUTYRIC ACID HYDROCHLORIDE (3S)-(-)-3-(TRIFLUOROACETAMIDO)PYRROLIDINE HYDROCHLORIDE (S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE 2-[(3,4-DICHLOROBENZYL)SULFANYL]-3-METHYL-6-(TRIFLUOROMETHYL)-4(3H)-PYRIMIDINONE 4-chloro-2-[(2,2,2-trifluoroacetyl)amino]benzenecarboxylic acid 1-(4-CHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBOXAMIDE ETHYL 2-CHLORO-3,3,3-TRIFLUORO-2-ISOCYANATOPROPANOATE

2,2,2-Trifluoroethyla

2,2,2-trifluoroethan-1-aMine chloride

2,2,2-trifluoroethanaminium chloride

2,2,2-TrifluoroethylaMine Hydrochloride, 97+%

TAF

TRIFLUOROETHYLAMINE HYDROCHLORIDE

2,2,2-TRIFLUOROETHYLAMINE HYDROCHLORIDE

2,2,2-TRIFLUORO-ETHYL-AMMONIUM CHLORIDE

2-AMINO-1,1,1-TRIFLUOROETHANE HYDROCHLORIDE

2,2,2-trifluoro-ethanaminhydrochloride

trifluoro-ethylaminhydrochloride

2,2,2-TrifluoroethylamineHCl

2,2,2-Trifluoroethanamine hydrochloride

2,2,2-TRIFLUORO-

2,2,2-Trifluoroethylamine hydrochloride 98%

2,2,2-Trifluoroethylaminehydrochloride98%

2,2,2-Trifluoroethylamine hydrochloride(99%)

2,2,2-Trifluoroethylamine hydrochloride ISO 9001：2015 REACH

2,2,2-Trifluoroaminehydrochloride

Upadacitinib Impurity 61 Hydrochloride

2,2,2-Trifluoro-ethanamine HCl

373-88-6

73-88-6

206-58-2

C2H4F3NxHCL

C2H4F3NHCl

CF3CH2NH2HCl

C2H5ClF3N

C2H4F3NClH

Amine Salts

Building Blocks

Organic Building Blocks

Nitrogen Compounds