2,2,2-Trifluoroethylamine hydrochloride
- Product Name
- 2,2,2-Trifluoroethylamine hydrochloride
- CAS No.
- 373-88-6
- Chemical Name
- 2,2,2-Trifluoroethylamine hydrochloride
- Synonyms
- TAF;2,2,2-Trifluoroethanamine hydrochloride;TRIFLUOROETHYLAMINE HYDROCHLORIDE;2,2,2-Trifluoroethyla;2,2,2-TRIFLUORO-;2,2,2-TrifluoroethylamineHCl;2,2,2-Trifluoro-ethanamine HCl;trifluoro-ethylaminhydrochloride;2,2,2-Trifluoroaminehydrochloride;2,2,2-trifluoroethanaminium chloride
- CBNumber
- CB4396448
- Molecular Formula
- C2H5ClF3N
- Formula Weight
- 135.52
- MOL File
- 373-88-6.mol
2,2,2-Trifluoroethylamine hydrochloride Property
- Melting point:
- 220-222 °C (subl.)(lit.)
- Density
- 1,24g/cm
- refractive index
- 1,3-1,302
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- color
- White to Light yellow to Light orange
- Water Solubility
- It is Soluble in 0.7 to water, but soluble in ethanol and chloroform, slightly soluble in benzene, hardly soluble in ether.
- Sensitive
- Hygroscopic
- BRN
- 3652103
- InChI
- InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H
- InChIKey
- ZTUJDPKOHPKRMO-UHFFFAOYSA-N
- SMILES
- C(F)(F)(F)CN.Cl
- CAS DataBase Reference
- 373-88-6(CAS DataBase Reference)
- EPA Substance Registry System
- Ethanamine, 2,2,2-trifluoro-, hydrochloride (373-88-6)
Safety
- Hazard Codes
- Xn,T,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 36/37-24/25-36-26
- WGK Germany
- 3
- RTECS
- KS0250000
- F
- 3-10-21
- Hazard Note
- Hygroscopic/Toxic
- TSCA
- T
- HazardClass
- IRRITANT
- PackingGroup
- III
- HS Code
- 29211990
- Toxicity
- LD50 unr-mus: 476 mg/kg 11FYAN 3,81,63
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 180386
- Product name
- 2,2,2-Trifluoroethylamine hydrochloride
- Purity
- 98%
- Packaging
- 10g
- Price
- $117.8
- Updated
- 2025/07/31
- Product number
- 180386
- Product name
- 2,2,2-Trifluoroethylamine hydrochloride
- Purity
- 98%
- Packaging
- 50g
- Price
- $271.7
- Updated
- 2025/07/31
- Product number
- T1170
- Product name
- 2,2,2-Trifluoroethylamine Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 5g
- Price
- $25
- Updated
- 2025/07/31
- Product number
- T1170
- Product name
- 2,2,2-Trifluoroethylamine Hydrochloride
- Purity
- >98.0%(N)(T)
- Packaging
- 25g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- T787295
- Product name
- 2,2,2-Trifluoroethylamine hydrochloride
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
2,2,2-Trifluoroethylamine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
WHITE TO LIGHT YELLOW CRYSTALLINE POWDER
Uses
2,2,2-Trifluoroethylamine Hydrochloride is a reagent in the synthesis of arachidonylethanolamide analogs. These show affinity for CB1 and CB2 cannabinoid receptors.
Safety Profile
Moderately toxic by unspecifiedroute. When heated to decomposition it emits very toxicfumes of F??, NOx, and HCl.
Synthesis
753-90-2
373-88-6
General procedure for the synthesis of 2,2,2-trifluoroethylamine hydrochloride from 2,2,2-trifluoroethylamine: 100 g of ethanol and 33 g of 2,2,2-trifluoroethylamine were added to a triple-necked flask, and 35 g of saturated hydrochloric acid solution was added slowly and dropwise at temperatures lower than 25°C. The reaction system was then brought up to 50°C and maintained there for 1 hour. After the dropwise addition, the temperature of the reaction system was raised to 50 °C and maintained for 1 hour. Subsequently, the temperature of the reaction solution was controlled to be 45±5°C under a vacuum of 0.98 MPa and a decompression distillation was carried out for 5 hours to remove water and ethanol. Finally 43.5 g of 2,2,2-trifluoroethylamine hydrochloride was obtained in 96.30% yield. The resulting product was a white powdery crystalline solid with 0.13% water.
References
[1] Patent: CN105801428, 2016, A. Location in patent: Paragraph 0016; 0017
2,2,2-Trifluoroethylamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,2,2-Trifluoroethylamine hydrochloride manufacturers
- Product
- 2,2,2-Trifluoroethylamine hydrochloride 373-88-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-11-26
- Product
- 2,2,2-trifluoroethanaminium chloride 373-88-6
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-08
- Product
- 2,2,2-Trifluoroethylamine hydrochloride 373-88-6
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100 tons
- Release date
- 2024-08-09