Bis(trimethylsilyl)trifluoroacetamide

Uses

Product Name: Bis(trimethylsilyl)trifluoroacetamide
CAS No.: 25561-30-2
Chemical Name: Bis(trimethylsilyl)trifluoroacetamide
Synonyms: BSTFA;N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE;Trimethylsilyl 2,2,2-trifluoro-N-(trimethylsilyl)acetimidate;N,O-BSTFA;N,O-Bis(Trimethylsilyl);N.O-Bis(trimethylsilyl)trifluoro acetamide (BSTFA);n,o-bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane;N,O-Bis(trimethylsilyl)trifluoroacetamide, contains 1% TMCS, ampuled under argon;bstfa kit;REGISIL RC-1
CBNumber: CB5464744
Molecular Formula: C8H18F3NOSi2
Formula Weight: 257.4
MOL File: 25561-30-2.mol

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Bis(trimethylsilyl)trifluoroacetamide Property

Melting point:: -10°C
Boiling point:: 45-50 °C14 mm Hg(lit.)
Density: 0.97 g/mL(lit.)
refractive index: n20/D 1.384(lit.)
Flash point:: 75 °C
storage temp.: 2-8°C
solubility: Miscible with chloroform.
form: Liquid
pka: 1.82±0.50(Predicted)
Specific Gravity: 0.971
color: Colorless to pale yellow
Water Solubility: hydrolyses
Sensitive: Moisture Sensitive
Hydrolytic Sensitivity: 8: reacts rapidly with moisture, water, protic solvents
BRN: 3607620
Stability:: Moisture Sensitive
InChI: 1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+
InChIKey: XCOBLONWWXQEBS-KPKJPENVSA-N
SMILES: C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F
CAS DataBase Reference: 25561-30-2(CAS DataBase Reference)
NIST Chemistry Reference: Bis(trimethylsilyl)trifluoroacetamide(25561-30-2)

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Safety

Hazard Codes: C,F,T
Risk Statements: 11-34-10-35-14
Safety Statements: 26-36/37/39-45-16
RIDADR: UN 2924 3/PG 3
WGK Germany: 3
F: 10-21
Hazard Note: Flammable/Moisture Sensitive
TSCA: Yes
HazardClass: 3
PackingGroup: III
HS Code: 29310095
Storage Class: 3 - Flammable liquids
Hazard Classifications: Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 2
Skin Corr. 1A

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B-023
Product name: BSTFA (with 1% TMCS)
Purity: kit of 10 × 1?mL, analytical standard, Cerilliant?
Packaging: 10x1mL
Price: $103
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15222
Product name: N,O-Bis(trimethylsilyl)trifluoroacetamide
Purity: for GC derivatization, LiChropur?, ≥99.0%
Packaging: 1mL
Price: $32.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15222
Product name: N,O-Bis(trimethylsilyl)trifluoroacetamide
Purity: for GC derivatization, LiChropur?, ≥99.0%
Packaging: 5ml
Price: $82.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15222
Product name: N,O-Bis(trimethylsilyl)trifluoroacetamide
Purity: for GC derivatization, LiChropur?, ≥99.0%
Packaging: 25mL
Price: $206
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15222
Product name: N,O-Bis(trimethylsilyl)trifluoroacetamide
Purity: for GC derivatization, LiChropur?, ≥99.0%
Packaging: 10x1mL
Price: $302
Updated: 2025/07/31

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Bis(trimethylsilyl)trifluoroacetamide Chemical Properties,Usage,Production

Uses

Bis(trimethylsilyl)trifluoroacetamide is used for synthesis of pharmaceutical intermediates.

Chemical Properties

Clear to yellowish clear liquid

Uses

Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties.

Uses

N,O-bis(trimethylsilyl)-trifluoroacetamide (BSTFA) is similar to BSA in specificity of modification and there are several studies which have used both reagents.One study found BSTFA superior to BSA in product stability and yield of derivative. Another study compared several trimethylsilyl donors for end-capping of silica and observed that BSTFA was more reactive than BSA but less reactive than TMCim. Both BSA and BSTFA were used to prepare trimethylsilyl derivatives of pyrimidines and purines.Current work has used BSTFA for metabolomics analysis of urine,for the measurement of khatamines (psychoactive amines of khat (Catha edulis Forsk), and for the measurement of acrylamide in cocoa.

Uses

N,O-Bis(trimethylsilyl)trifluoroacetamide is used for analytical purposes or as a chemical reagent for synthesis of more complex molecules. It is silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions. It is also used as DAT inhibitor and a SLC6A2 inhibitor. It is routinely used to derivatize carboxylic acids, phenols, steroids, amines, alcohols, and alkaloids and amides.

Definition

ChEBI: A silyl ether that is the N,O-bis(trimethylsilyl) derivative of trifluoroacetamide. N,O-bis(trimethylsilyl)trifluoroacetamide is a derivatisation agent used in gas chromatography/m ss spectrometry applications.

General Description

Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane has found application to be used in gas chromatography (GC) and mass-spectrometry (MS). It can also be used in HPLC- electrochemical detection assay of 8-oxo-deoxyguanosine and?8-oxo-guanine.

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

Synthesis

A process for N,O-bis-trimethylsilyltrifluoroacetamide:
N,O-bis-trimethylsilyltrifluoroacetamide, whose molecular formula is CF3CON[(CH3)3Si]2, is a kind of methylsilylating reagent, which is composed of raw materials of trimethylchlorosilane, triethylamine, and trifluoroacetamide, and is characterized in the following way: the said raw materials of trimethylchlorosilane, triethylamine, and trifluoroacetamide are in the ratio of moles of 1.2-4:2-4:1, respectively, and the process of synthesizing N,O-bis-trimethylsilyltrifluoroacetamide is to put into the reactor when synthesizing. The synthesized N,O-bis(trimethylsilyl)trifluoroacetamide is synthesized by putting triethylamine and trifluoroacetamide into the reactor and stirring for 1 hour, and then adding chlorotrimethylsilane dropwise into the reactor under the protection of N2 gas, controlling the temperature in the range of <50??, and refilling it in 2-6 hours, and then protecting the reaction in 40-65?? for 8-16 hours, and then lowering the temperature to less than 35?? and discharging the material at the end of the reaction. The finished reaction material is added to the closed centrifuge for solid-liquid separation, and the mother liquor is sent to the concentration kettle for concentration, the concentration temperature is controlled between 60-100??, and the pressure is from -0.2 to -08 atmospheric pressure. Then the concentrated mother liquor will be sent to distillation kettle for distillation, the distillation conditions: temperature control at 60-100 ??, pressure of -0.2 to -0.998 atmospheric pressure, tower height of 6-15 meters, after distillation of colorless and transparent liquids, and then packaged under the protection of N2 gas to get its finished products.

Bis(trimethylsilyl)trifluoroacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Bis(trimethylsilyl)trifluoroacetamide Suppliers

Americas 1 Belgium 1 Canada 2 China 454 Europe 4 France 2 Germany 9 India 25 Ireland 1 Italy 1 Japan 8 Norway 1 Poland 1 Russia 1 Singapore 1 Slovakia 1 Switzerland 2 United Kingdom 20 United States 62 Global 597

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25522
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TCI (Shanghai) Development Co., Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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View Lastest Price from Bis(trimethylsilyl)trifluoroacetamide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Bis(trimethylsilyl)trifluoroacetamide 25561-30-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-11

Hebei Chuanghai Biotechnology Co., Ltd

Product: Bis(trimethylsilyl)trifluoroacetamide 25561-30-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-09

Henan Aochuang Chemical Co.,Ltd.

Product: Bis(trimethylsilyl)trifluoroacetamide 25561-30-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

25561-30-2, Bis(trimethylsilyl)trifluoroacetamideRelated Search:

Trifluoroacetamide TRIMETHYLSILANE Azidotrimethylsilane Methyltris(methylethylketoxime)silane Iodotrimethylsilane N-6-Trifluoroacetyl-L-lysine Methyltriethoxysilane Acetamide N,O-Bis(trimethylsilyl)acetamide Hexamethyldisilane N-(Trimethylsilyl)acetamide Trifluoroacetamidine Methyltrichlorosilane Dichlorodimethylsilane Bis-(9,9-diMethyl-9H-fluoren-2-yl)-aMine tert-Butyldimethylsilyl chloride N,N'-Dimethyl-1,2-ethanediamine N,N-Bis(2-cyanoethyl)formamide

BSTFA containing 1% TMCS

N,O-Bis(trimethylsily)trifluoroamide

N,O-bis(trimethylsilyl)acetamide,*with 10%

N,O-Bis(trimethylsilyl)trifluoroacetamide, contains 10% TMCS

N,O-Bis(trimethylsilyl)trifluoroacetamide, contains 1% TMCS, ampuled under argon

Bis(trimethylsilyl)trifluoroacetamide for gas chromatography

Acetamide, 2,2,2-trifluoro-O,N-bis(trimethylsilyl)-

Ethanimidic acid, 2,2,2-trifluoro-N-(trimethylsilyl)-, trimethylsilyl ester

N,O-bis(trimehylsilyl)trifluoroacetamide

N,O-BSTFA

N.O-Bis(trimethylsilyl)trifluoro acetamide (BSTFA)

bis(Trifluoromethylsilyl)trifluoroacetamide

BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE, 9 9+%, DERIVATIZATION GRADE

BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE*(B STFA) BULK

BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE, 9 9+%

N,O-BIS-(TRIMETHYLSILYL)-TRIFLUOR-ACETAM ID, PURISS.>99% (GC)

N,O-BIS(TRIMETHYLSILYL)TRIFLUORO-ACETAMI DE, FOR GC

BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE*(B STFA) WITH

BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE*(B STFA) SEALE

N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE WITH TRIMETHYLCHLOROSILANE, 98% (EXCLUDING TMCS)

BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE, 9 9%, WITH 1% TMCS

N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACET-AMI DE, PGE 10 X 1 ML

N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACET-AMI DE WITH 1% TMCS

N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACET-AMI DE 1% TMCS 10X1ML

BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE 99% WITH 1%TMCS PACKAGED UNDER ARGON IN RESEALABLE CHEMSEAL– BOTTLES

N,O-BIS(TRIMETHYLSILYL) TRIFLUOROACETAMIDE 98+%

N.O-Bis(Trimethylsilyl)Trifluoroacetamide(Bstfa),Finasteride

N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+% , BSTFA

BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE WITH 10%TMCS

BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE(BSTFA)

N,O-Bis(trimethylsilyl)trifluoroacetamide99+%

N,O-Bis(trimethylsilyl)trifluoroacetamide, packaged in 1 ml ampules, 98%

N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% trimethylsilyl chloride

N,0-Bis(trimethylsilyl)trifluoroacetamideBSTFA

N,O-Bis(Trimethylsilyl)

bstfa + tmcs

2,2,2-Trifluoro-1-trimethylsiloxy-N-trimethylsilylethanimine

2,2,2-Trifluoro-N-(trimethylsilyl)acetimidic acid trimethylsilyl ester

2,2,2-Trifluoro-N-(trimethylsilyl)ethanimidic acid trimethylsilyl ester

N-(Trimethylsilyl)-1-(trimethylsilyloxy)-2,2,2-trifluoroethanimine

N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, packaged under Argon in resealable ChemSeal^t bottles

N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, packaged under Argon in resealable ChemSeal

N,O-Bis(trimethylsilyl)trifluoroacetamide, 99+%, packaged under Argon in resealable ChemSeal^t bottl

BSTFA-TMCS (99:1) [Derivatizing Reagent for GC]

BSTFA [=N,O-Bis(trimethylsilyl)trifluoroacetamide]

N,O-Bis(trimethylsilyl)trifluoroacetamide ,97.5%

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane,BSTFA + TMCS, Silylating mixture Fluka V

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane,BSTFA + TMCS

BSTFA (with 1% TMCS), 10 amps.

N,O-Bis(trimethylsilyl)trifluoroacetamide, packaged in 1 ml ampoules, 98%

N,O-Bis(trimethylsilyl)trifluoroacetamide derivatization grade

N,O-Bis(trimethylsilyl)trifluoroacetamide, 99+%, packaged under Argon in resealable ChemSeal^t bottles

BSTFA (with 1% TMCS)

Bis(trimethylsilyl)trifluoroacetamide 99%

N,O-Bis(trimethylsilyl)trifluoroacetamide, 98%, J&KSeal

N,O-Bis(trimethylsilyl)trifluoroacetimide

Trimethylsilyl N-(trimethylsilyl)trifluoroacetimidate 99%

(1E)-2,2,2-trifluoro-N-trimethylsilylethanimidic acid trimethylsilyl ester