Bis(trimethylsilyl)trifluoroacetamide Property

Melting point:

-10°C

Boiling point:

45-50 °C14 mm Hg(lit.)

Density 

0.97 g/mL(lit.)

refractive index 

n20/D 1.384(lit.)

Flash point:

75 °C

storage temp. 

2-8°C

solubility 

Miscible with chloroform.

form 

Liquid

pka

1.82±0.50(Predicted)

Specific Gravity

0.971

color 

Colorless to pale yellow

Water Solubility 

hydrolyses

Sensitive 

Moisture Sensitive

Hydrolytic Sensitivity

8: reacts rapidly with moisture, water, protic solvents

BRN 

3607620

Stability:

Moisture Sensitive

InChIKey

XCOBLONWWXQEBS-KPKJPENVSA-N

CAS DataBase Reference

25561-30-2(CAS DataBase Reference)

NIST Chemistry Reference

Bis(trimethylsilyl)trifluoroacetamide(25561-30-2)

Safety

Hazard Codes 

C,F,T

Risk Statements 

11-34-10-35-14

Safety Statements 

26-36/37/39-45-16

RIDADR 

UN 2924 3/PG 3

WGK Germany 

3

F 

10-21

Hazard Note 

Flammable/Moisture Sensitive

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29310095

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Bis(trimethylsilyl)trifluoroacetamide Chemical Properties,Usage,Production

Uses

Used for synthesis of pharmaceutical intermediates.

Chemical Properties

Clear to yellowish clear liquid

Uses

Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties.

Uses

N,O-bis(trimethylsilyl)-trifluoroacetamide (BSTFA) is similar to BSA in specificity of modification and there are several studies which have used both reagents.One study found BSTFA superior to BSA in product stability and yield of derivative. Another study compared several trimethylsilyl donors for end-capping of silica and observed that BSTFA was more reactive than BSA but less reactive than TMCim. Both BSA and BSTFA were used to prepare trimethylsilyl derivatives of pyrimidines and purines.Current work has used BSTFA for metabolomics analysis of urine,for the measurement of khatamines (psychoactive amines of khat (Catha edulis Forsk), and for the measurement of acrylamide in cocoa.

Uses

N,O-Bis(trimethylsilyl)trifluoroacetamide is used for analytical purposes or as a chemical reagent for synthesis of more complex molecules. It is silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions. It is also used as DAT inhibitor and a SLC6A2 inhibitor. It is routinely used to derivatize carboxylic acids, phenols, steroids, amines, alcohols, and alkaloids and amides.

Definition

ChEBI: A silyl ether that is the N,O-bis(trimethylsilyl) derivative of trifluoroacetamide. N,O-bis(trimethylsilyl)trifluoroacetamide is a derivatisation agent used in gas chromatography/m ss spectrometry applications.

General Description

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane has found application to be used in gas chromatography (GC) and mass-spectrometry (MS). It can also be used in HPLC- electrochemical detection assay of 8-oxo-deoxyguanosine and?8-oxo-guanine.