N-6-Trifluoroacetyl-L-lysine

Product Name: N-6-Trifluoroacetyl-L-lysine
CAS No.: 10009-20-8
Chemical Name: N-6-Trifluoroacetyl-L-lysine
Synonyms: Ε-TFA-LYSINE;LYR(TFA)-TYR;LYS(TFA)-TYR;H-LYS(TFA)-OH;L-Lys(Tfa)-OH;LYSINE(TFA)-OH;H-LYS(CF3CO)-OH;EPSILON-TFA-LYSINE;n(epsilon)-trifluoro;Trifluoroacetyllysine
CBNumber: CB4249490
Molecular Formula: C8H13F3N2O3
Formula Weight: 242.2
MOL File: 10009-20-8.mol

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N-6-Trifluoroacetyl-L-lysine Property

Melting point:: 258
Boiling point:: 382.5±42.0 °C(Predicted)
Density: 1.4
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: 2 M HCl: 10 mg/mL, clear, colorless
pka: 2.51±0.24(Predicted)
form: Solid
color: Off-White
BRN: 2122429
InChI: InChI=1S/C8H13F3N2O3/c9-8(10,11)7(16)13-4-2-1-3-5(12)6(14)15/h5H,1-4,12H2,(H,13,16)(H,14,15)/t5-/m0/s1
InChIKey: PZZHRSVBHRVIMI-YFKPBYRVSA-N
SMILES: C(O)(=O)[C@H](CCCCNC(C(F)(F)F)=O)N

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Safety

Safety Statements: 22-24/25
WGK Germany: 1
F: 10
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 53604
Product name: Nε-Trifluoroacetyl-L-lysine
Purity: ≥96.0% (TLC)
Packaging: 5G
Price: $77.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 53604
Product name: Nε-Trifluoroacetyl-L-lysine
Purity: ≥96.0% (TLC)
Packaging: 25g
Price: $229
Updated: 2023/06/20

TCI Chemical

Product number: T2815
Product name: Nε-Trifluoroacetyl-L-lysine
Purity: >98.0%(T)
Packaging: 5g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: T2815
Product name: Nε-Trifluoroacetyl-L-lysine
Purity: >98.0%(T)
Packaging: 25g
Price: $56
Updated: 2025/07/31

TRC

Product number: T788500
Product name: N6-Trifluoroacetyl-L-lysine
Packaging: 25g
Price: $85
Updated: 2021/12/16

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N-6-Trifluoroacetyl-L-lysine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A cysteine conjugate metabolite adduct formation with specific mitochondrial proteins using antibodies raised against halothane metabolite adducts.

Definition

ChEBI: An N6-acyl-L-lysine where the N6-acyl group is trifluoroacetyl.

Biological Activity

Nε-Trifluoroacetyl-L-lysine is an inhibitor of L-lysine cyclodeaminase.', 'Nε-Trifluoroacetyl-L-lysine may be used to create synthetic organic polypeptides useful for nonaqueous capillary electrophoresis (NACE).

Synthesis

383-63-1

657-27-2

10009-20-8

1. Sodium ethanolate solution was prepared by dissolving sodium metal (4.6 g, 0.2 mol) in 200 mL of anhydrous ethanol. 2. L-lysine hydrochloride (18.25 g, 0.1 mol) was slowly added to the above solution under stirring conditions. 3. The reaction mixture was stirred continuously for 1 hour, followed by filtration to remove the insoluble precipitate. 4. The filtrate was cooled in an ice bath and ethyl trifluoroacetate (21.3 g, 0.15 mol) was added slowly and dropwise with vigorous stirring. 5. The reaction mixture was gradually warmed to room temperature and stirring was continued for 2 hours. 6. Acetic acid (6 g, 0.1 mol) was added to neutralize the reaction system and the resulting precipitate was subsequently collected by filtration. 7. The precipitate was washed sequentially with ethanol and acetone and dried to give the target product trifluoroacetyl lysine. 8. Yield: 15 g (62% yield). 9. MALDI-TOF mass spectrometry (positive ion mode): m/z 242.455 ([M+H]+, relative abundance 67%).

References

[1] Russian Journal of Organic Chemistry, 2007, vol. 43, # 10, p. 1427 - 1431
[2] Patent: WO2009/114809, 2009, A1. Location in patent: Page/Page column 7
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 255 - 258

N-6-Trifluoroacetyl-L-lysine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-6-Trifluoroacetyl-L-lysine Suppliers

Canada 1 China 332 Europe 2 Germany 5 India 25 Japan 5 Norway 1 Slovakia 1 South Korea 1 Switzerland 2 United Kingdom 7 United States 40 Global 422

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View Lastest Price from N-6-Trifluoroacetyl-L-lysine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N-6-Trifluoroacetyl-L-lysine 10009-20-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

airuikechemical co., ltd.

Product: n-6-trifluoroacetyl-l-lysine 10009-20-8
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-6-Trifluoroacetyl-L-lysine 10009-20-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

10009-20-8, N-6-Trifluoroacetyl-L-lysineRelated Search:

Trifluoroacetyl chloride BOC-TRP-N(OCH3)CH3 Sodium triacetoxyborohydride HEXAFLUOROACETYLACETONE Acetylacetone Triethyl acetyl citrate Poly-L-lysine N-ACETYL-L-TYROSINE ETHYL ESTER DL-Lysine acetylsalicylate L-Lysine 3,3-Dimethyl-2-oxobutyric acid H-Lys-OBzl·HCl·TosOH Ethyl 2,6-diaminohexanoate dihydrochloride 6-Azido-L-norleucine HCl H-Lys(Mtt)-OH H-Lys-Leu-Lys-OH N6-Cbz-L-Lysine benzyl ester hydrochloride Lysine(propionyl)- OH

H-LYS(TFA)-OH

H-LYS(CF3CO)-OH

EPSILON-TFA-LYSINE

LYSINE(TFA)-OH

N-EPSILON-TRIFLUOROACETYL-L-LYSINE

N6-TRIFLUOROACETYL-L-LYSINE

N6-Trrifluoroacetyl-L-lysine(for Lisinopril)

N6-Trifluoroacetyl-L-lysine 98%

INTERMEDIATE OF QUINAPRIL/N6-TRIFLUOROACETYL-L-LYSINE

N-6-TRIFLUORO ACETYL-L-LYSINE ( LISINOPRIL INTERMEDIATE )

N6-Trifluoroacetyl-L-lysine98%

N(6)-Trifluoracetyl-L-Lysin

Ε-TFA-LYSINE

N-ε-Trifluoroacetyl-L-lysine

N1-Trifluoroacetyl-L-Lysine

N6-Trifluoroaccety-L-lysine

N6-Trifluoroacetyl-L-lysine (for lisinopril)

(2S)-2-amino-6-(2,2,2-trifluoroacetamido)hexanoic acid

(2S)-2-amino-6-(trifluoroacetamido)hexanoic acid

(S)-2-aMino-6-(2,2,2-trifluoroacetaMido)hexanoic acid

n(epsilon)-trifluoro

N-E-TRIFLUOROACETYL-L-LYSINE

Trifluoroacetyllysine

LYR(TFA)-TYR

N6-Tryfluoro Acetyl-L-Lysine

Nε-Trifluoroacetyl-L-lysine

(S)-2-AMino-6-(2,2,2-trifluoro-acetylaMino)-hexanoic acid

LYS(TFA)-TYR

L-Lys(Tfa)-OH

Nε-Trifluoroacetyl-L-lysine≥ 99% (Assay)

ε-TFA-lysine H-Lys(Tfa)-OH

Lys(tfa)-OH / K(Tfa)

L-Lysine, N6-(2,2,2-trifluoroacetyl)-

N-6-Trifluoroacetyl-L-lysine USP/EP/BP

N-6-Trifluoroacetyl-L-Lysine extrapure, 98%

N6-(2,2,2-Trifluoroacetyl)-L-lysine

Nε-Trifluoroacetyl Lysine

Nε-Trifluoroacetyl-<sc>L</sc>-lysine

(S)-2-Amino-6-(2,2,2-trifluoro-acetcarboxcarboxcarboxamido)-hexanoic acid

10009-20-8

10009-60-8

C8H13F3N2O3

C8H13N2O3F3

Specialty Synthesis

Lysine

Peptide Synthesis

Amino Acid Derivatives

Amino Acids & Derivatives, Metabolites & Impurities

Amino Acids & Derivatives

Metabolites & Impurities

amino acid

API intermediates

Chemical intermediate for LISINOPRIL

10009-20-8