Uses
ChemicalBook > CAS DataBase List > Bis(trimethylsilyl)trifluoroacetamide

Bis(trimethylsilyl)trifluoroacetamide

Uses
Product Name
Bis(trimethylsilyl)trifluoroacetamide
CAS No.
25561-30-2
Chemical Name
Bis(trimethylsilyl)trifluoroacetamide
Synonyms
BSTFA;N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE;Trimethylsilyl 2,2,2-trifluoro-N-(trimethylsilyl)acetimidate;N,O-BSTFA;N,O-Bis(Trimethylsilyl);N.O-Bis(trimethylsilyl)trifluoro acetamide (BSTFA);n,o-bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane;N,O-Bis(trimethylsilyl)trifluoroacetamide, contains 1% TMCS, ampuled under argon;bstfa kit;REGISIL RC-1
CBNumber
CB5464744
Molecular Formula
C8H18F3NOSi2
Formula Weight
257.4
MOL File
25561-30-2.mol
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Bis(trimethylsilyl)trifluoroacetamide Property

Melting point:
-10°C
Boiling point:
45-50 °C14 mm Hg(lit.)
Density 
0.97 g/mL(lit.)
refractive index 
n20/D 1.384(lit.)
Flash point:
75 °C
storage temp. 
2-8°C
solubility 
Miscible with chloroform.
form 
Liquid
pka
1.82±0.50(Predicted)
Specific Gravity
0.971
color 
Colorless to pale yellow
Water Solubility 
hydrolyses
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
BRN 
3607620
Stability:
Moisture Sensitive
InChIKey
XCOBLONWWXQEBS-KPKJPENVSA-N
CAS DataBase Reference
25561-30-2(CAS DataBase Reference)
NIST Chemistry Reference
Bis(trimethylsilyl)trifluoroacetamide(25561-30-2)
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Safety

Hazard Codes 
C,F,T
Risk Statements 
11-34-10-35-14
Safety Statements 
26-36/37/39-45-16
RIDADR 
UN 2924 3/PG 3
WGK Germany 
3
F 
10-21
Hazard Note 
Flammable/Moisture Sensitive
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29310095
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B-023
Product name
BSTFA (with 1% TMCS)
Purity
kit of 10 × 1?mL, analytical standard, Cerilliant?
Packaging
10x1mL
Price
$98.3
Updated
2024/03/01
Sigma-Aldrich
Product number
15222
Product name
N,O-Bis(trimethylsilyl)trifluoroacetamide
Purity
for GC derivatization, LiChropur?, ≥99.0%
Packaging
1mL
Price
$30.5
Updated
2024/03/01
Sigma-Aldrich
Product number
15222
Product name
N,O-Bis(trimethylsilyl)trifluoroacetamide
Purity
for GC derivatization, LiChropur?, ≥99.0%
Packaging
5ml
Price
$78.6
Updated
2024/03/01
Sigma-Aldrich
Product number
15222
Product name
N,O-Bis(trimethylsilyl)trifluoroacetamide
Purity
for GC derivatization, LiChropur?, ≥99.0%
Packaging
25mL
Price
$195
Updated
2024/03/01
Sigma-Aldrich
Product number
15222
Product name
N,O-Bis(trimethylsilyl)trifluoroacetamide
Purity
for GC derivatization, LiChropur?, ≥99.0%
Packaging
10x1mL
Price
$286
Updated
2024/03/01
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Bis(trimethylsilyl)trifluoroacetamide Chemical Properties,Usage,Production

Uses

Used for synthesis of pharmaceutical intermediates.

Chemical Properties

Clear to yellowish clear liquid

Uses

Used as a reactant in the preparation of pyrimidinone ribosides and analogs that show anti-tumor properties.

Uses

N,O-bis(trimethylsilyl)-trifluoroacetamide (BSTFA) is similar to BSA in specificity of modification and there are several studies which have used both reagents.One study found BSTFA superior to BSA in product stability and yield of derivative. Another study compared several trimethylsilyl donors for end-capping of silica and observed that BSTFA was more reactive than BSA but less reactive than TMCim. Both BSA and BSTFA were used to prepare trimethylsilyl derivatives of pyrimidines and purines.Current work has used BSTFA for metabolomics analysis of urine,for the measurement of khatamines (psychoactive amines of khat (Catha edulis Forsk), and for the measurement of acrylamide in cocoa.

Uses

N,O-Bis(trimethylsilyl)trifluoroacetamide is used for analytical purposes or as a chemical reagent for synthesis of more complex molecules. It is silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions. It is also used as DAT inhibitor and a SLC6A2 inhibitor. It is routinely used to derivatize carboxylic acids, phenols, steroids, amines, alcohols, and alkaloids and amides.

Definition

ChEBI: A silyl ether that is the N,O-bis(trimethylsilyl) derivative of trifluoroacetamide. N,O-bis(trimethylsilyl)trifluoroacetamide is a derivatisation agent used in gas chromatography/m ss spectrometry applications.

General Description

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane has found application to be used in gas chromatography (GC) and mass-spectrometry (MS). It can also be used in HPLC- electrochemical detection assay of 8-oxo-deoxyguanosine and?8-oxo-guanine.

Bis(trimethylsilyl)trifluoroacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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Bis(trimethylsilyl)trifluoroacetamide Suppliers

Americas 1 Belgium 1 Canada 2 China 381 Europe 4 France 2 Germany 9 India 25 Ireland 1 Italy 1 Japan 8 Norway 1 Poland 1 Russia 1 Singapore 1 Slovakia 1 Switzerland 2 United Kingdom 20 United States 63 Global 525
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View Lastest Price from Bis(trimethylsilyl)trifluoroacetamide manufacturers

airuikechemical co., ltd.
Product
bis(trimethylsilyl)trifluoroacetamide 25561-30-2
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08
Henan Fengda Chemical Co., Ltd
Product
bis(trimethylsilyl)trifluoroacetamide 25561-30-2
Price
US $8.00-0.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-22
Hebei Duling International Trade Co. LTD
Product
Bis(trimethylsilyl)trifluoroacetamide 25561-30-2
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2023-03-14

25561-30-2, Bis(trimethylsilyl)trifluoroacetamideRelated Search:

Trifluoroacetamide TRIMETHYLSILANE Azidotrimethylsilane Methyltris(methylethylketoxime)silane Iodotrimethylsilane N-6-Trifluoroacetyl-L-lysine Methyltriethoxysilane Acetamide N,O-Bis(trimethylsilyl)acetamide Hexamethyldisilane N-(Trimethylsilyl)acetamide Trifluoroacetamidine tert-Butyldimethylsilyl chloride Methyltrichlorosilane Dichlorodimethylsilane Bis-(9,9-diMethyl-9H-fluoren-2-yl)-aMine N,N'-Dimethyl-1,2-ethanediamine N,N-Bis(2-cyanoethyl)formamide

  • BSTFA containing 1% TMCS
  • N,O-Bis(trimethylsily)trifluoroamide
  • N,O-bis(trimethylsilyl)acetamide,*with 10%
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, contains 10% TMCS
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, contains 1% TMCS, ampuled under argon
  • Bis(trimethylsilyl)trifluoroacetamide for gas chromatography
  • Acetamide, 2,2,2-trifluoro-O,N-bis(trimethylsilyl)-
  • Ethanimidic acid, 2,2,2-trifluoro-N-(trimethylsilyl)-, trimethylsilyl ester
  • N,O-bis(trimehylsilyl)trifluoroacetamide
  • N,O-BSTFA
  • N.O-Bis(trimethylsilyl)trifluoro acetamide (BSTFA)
  • bis(Trifluoromethylsilyl)trifluoroacetamide
  • BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE, 9 9+%, DERIVATIZATION GRADE
  • BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE*(B STFA) BULK
  • BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE, 9 9+%
  • N,O-BIS-(TRIMETHYLSILYL)-TRIFLUOR-ACETAM ID, PURISS.>99% (GC)
  • N,O-BIS(TRIMETHYLSILYL)TRIFLUORO-ACETAMI DE, FOR GC
  • BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE*(B STFA) WITH
  • BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE*(B STFA) SEALE
  • N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE WITH TRIMETHYLCHLOROSILANE, 98% (EXCLUDING TMCS)
  • BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE, 9 9%, WITH 1% TMCS
  • N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACET-AMI DE, PGE 10 X 1 ML
  • N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACET-AMI DE WITH 1% TMCS
  • N,O-BIS(TRIMETHYLSILYL)TRIFLUOROACET-AMI DE 1% TMCS 10X1ML
  • BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE 99% WITH 1%TMCS PACKAGED UNDER ARGON IN RESEALABLE CHEMSEAL– BOTTLES
  • N,O-BIS(TRIMETHYLSILYL) TRIFLUOROACETAMIDE 98+%
  • N.O-Bis(Trimethylsilyl)Trifluoroacetamide(Bstfa),Finasteride
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+% , BSTFA
  • BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE WITH 10%TMCS
  • BIS(TRIMETHYLSILYL)TRIFLUOROACETAMIDE(BSTFA)
  • N,O-Bis(trimethylsilyl)trifluoroacetamide99+%
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, packaged in 1 ml ampules, 98%
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% trimethylsilyl chloride
  • N,0-Bis(trimethylsilyl)trifluoroacetamideBSTFA
  • N,O-Bis(Trimethylsilyl)
  • bstfa + tmcs
  • bstfa kit
  • 2,2,2-Trifluoro-1-trimethylsiloxy-N-trimethylsilylethanimine
  • 2,2,2-Trifluoro-N-(trimethylsilyl)acetimidic acid trimethylsilyl ester
  • 2,2,2-Trifluoro-N-(trimethylsilyl)ethanimidic acid trimethylsilyl ester
  • N-(Trimethylsilyl)-1-(trimethylsilyloxy)-2,2,2-trifluoroethanimine
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, packaged under Argon in resealable ChemSeal^t bottles
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, with 1% TMCS, packaged under Argon in resealable ChemSeal
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, 99+%, packaged under Argon in resealable ChemSeal^t bottl
  • BSTFA-TMCS (99:1) [Derivatizing Reagent for GC]
  • BSTFA [=N,O-Bis(trimethylsilyl)trifluoroacetamide]
  • N,O-Bis(trimethylsilyl)trifluoroacetamide ,97.5%
  • N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane,BSTFA + TMCS, Silylating mixture Fluka V
  • N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane,BSTFA + TMCS
  • BSTFA (with 1% TMCS), 10 amps.
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, packaged in 1 ml ampoules, 98%
  • N,O-Bis(trimethylsilyl)trifluoroacetamide derivatization grade
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, 99+%, packaged under Argon in resealable ChemSeal^t bottles
  • BSTFA (with 1% TMCS)
  • Bis(trimethylsilyl)trifluoroacetamide 99%
  • N,O-Bis(trimethylsilyl)trifluoroacetamide, 98%, J&KSeal
  • N,O-Bis(trimethylsilyl)trifluoroacetimide
  • Trimethylsilyl N-(trimethylsilyl)trifluoroacetimidate 99%