3-TRIMETHYLSILYL-2-PROPYN-1-OL

Product Name: 3-TRIMETHYLSILYL-2-PROPYN-1-OL
CAS No.: 5272-36-6
Chemical Name: 3-TRIMETHYLSILYL-2-PROPYN-1-OL
Synonyms: 3-(triMethylsilyl)prop-2-yn-1-ol;3-(TRIMETHYLSILYL)PROPARGYL ALCOHOL;3-TRIMETHYLSILANYL-PROP-2-YN-1-OL;3-Trimethylsilyl-2-propyn-1-ol,99%;2-Propyn-1-ol, 3-(trimethylsilyl)-;3-(Trimethylsilyl)propargyl alcohol 99%;DKSI027;TIMTEC-BB SBB009061;Trimethylsilylpropynol;3-Trimethylsilylpropargyl
CBNumber: CB2482992
Molecular Formula: C6H12OSi
Formula Weight: 128.24
MOL File: 5272-36-6.mol

More

Less

3-TRIMETHYLSILYL-2-PROPYN-1-OL Property

Melting point:: 63.5-65.0 °C
Boiling point:: 76 °C11 mm Hg(lit.)
Density: 0.865 g/mL at 25 °C(lit.)
refractive index: n20/D 1.451(lit.)
Flash point:: 152 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Benzene (Sparingly)
pka: 13.71±0.10(Predicted)
form: Liquid
color: Clear yellow
Specific Gravity: 0.865
Water Solubility: Not miscible with water.
Sensitive: Moisture Sensitive
Hydrolytic Sensitivity: 4: no reaction with water under neutral conditions
BRN: 1902505
InChIKey: ZVGCJDPEKKEYES-UHFFFAOYSA-N
CAS DataBase Reference: 5272-36-6(CAS DataBase Reference)
NIST Chemistry Reference: 3-Trimethylsilylpropargyl alcohol(5272-36-6)
EPA Substance Registry System: 2-Propyn-1-ol, 3-(trimethylsilyl)- (5272-36-6)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 23-24/25-37/39-26
RIDADR: 2810
WGK Germany: 3
F: 8-10
TSCA: Yes
HazardClass: 6.1
PackingGroup: III
HS Code: 29319090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 318558
Product name: 3-(Trimethylsilyl)propargyl alcohol
Purity: 99%
Packaging: 5g
Price: $66.9
Updated: 2025/07/31

TCI Chemical

Product number: T1500
Product name: 3-Trimethylsilyl-2-propyn-1-ol
Purity: >95.0%(GC)
Packaging: 5mL
Price: $85
Updated: 2025/07/31

TRC

Product number: T798175
Product name: TrimethylsilylpropargylAlcohol
Packaging: 5g
Price: $180
Updated: 2021/12/16

GFS CHEMICALS

Product number: 83533
Product name: 3-TMSPROPARGYLALCOHOL
Packaging: 250g
Price: $765.45
Updated: 2021/12/16

Oakwood

Product number: S20100
Product name: 3-(Trimethylsilyl)propargyl alcohol
Packaging: 1g
Price: $10
Updated: 2021/12/16

More

Less

3-TRIMETHYLSILYL-2-PROPYN-1-OL Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

Trimethylsilylpropargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.

Application

3-Trimethylsilyl-2-propyn-1-ol is a colourless transparent liquid which is sensitive to light, air and moisture, and can be used as raw material for organic synthesis or reaction reagent. Alkyllithiums undergo trans addition to 3-(trimethylsilyl)-2-propyn-1-ols to yield (1-lithiovinyl)silanes. Due to unidentified side-reactions, yields do not exceed 20%.

Synthesis

36551-06-1

5272-36-6

Compound 5 (0.250 g, 1.17 mmol) was added dropwise to a flask containing methanol (4.0 mL) and Amberlyst-15 (0.025 g) under nitrogen protection at a reaction temperature of 0 °C. The reaction mixture was warmed to 40 °C and stirred for 8 hours. Upon completion of the reaction, the resin was removed by filtration and washed with ethyl acetate (10 mL). To the filtrate, 10% aqueous hydrochloric acid (10 mL) was added, followed by extraction of the organic layer with ethyl acetate (3 x 10 mL). The organic phases were combined and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by column chromatography (eluent: hexane/ethyl acetate = 9:1) to afford compound 6 in 96% yield (0.143 g, 1.12 mmol).

References

[1] Tetrahedron, 1996, vol. 52, # 21, p. 7487 - 7510
[2] Journal of the Brazilian Chemical Society, 2013, vol. 24, # 12, p. 1933 - 1941
[3] Chemistry - A European Journal, 2015, vol. 21, # 27, p. 9662 - 9665
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987, p. 1077 - 1082
[5] Journal of Organic Chemistry, 1995, vol. 60, # 14, p. 4650 - 4652

3-TRIMETHYLSILYL-2-PROPYN-1-OL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-TRIMETHYLSILYL-2-PROPYN-1-OL Suppliers

Belgium 1 China 175 Germany 2 India 4 Japan 3 Singapore 1 Slovakia 1 Switzerland 2 United Kingdom 7 United States 32 Global 228

New Energy Chemicals

Tel: 0515-82159099 13770142076
Fax: 86-0515-8215909
Email: info@njuchem.com
Country: China
ProdList: 242
Advantage: 65

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

More

Less

View Lastest Price from 3-TRIMETHYLSILYL-2-PROPYN-1-OL manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-TRIMETHYLSILYL-2-PROPYN-1-OL 5272-36-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-25

LY Global chemicals co.,ltd .

Product: 3-TRIMETHYLSILYL-2-PROPYN-1-OL 5272-36-6
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 98%Min
Supply Ability: 1000kg
Release date: 2023-03-15

Dideu Industries Group Limited

Product: 3-TRIMETHYLSILYL-2-PROPYN-1-OL 5272-36-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-05

5272-36-6, 3-TRIMETHYLSILYL-2-PROPYN-1-OLRelated Search:

Trifluoroacetamide SULFUR TRIOXIDE TRIMETHYLAMINE COMPLEX Boron trifluoride tetrahydrofuran complex METHYL 3-(TRIMETHYLSILYL)PROPIOLATE 3-TRIMETHYLSILYL-2-PROPYN-1-OL 4-TRIMETHYLSILYL-3-BUTYN-2-OL 2-METHYL-4-TRIMETHYLSILYL-3-BUTYN-2-OL 3-(TRIMETHYLSILYL)PROPIOLIC ACID 3-TERT-BUTYLDIMETHYLSILYL-2-PROPYN-1-OL Propyne Propargyl alcohol 3-METHYL-1-TRIMETHYLSILYL-1-PENTYN-3-OL (+/-) TRIMETHYLSILYL(TRIMETHYLSILYL)PROPYNOATE ETHYL 3-(TRIMETHYLSILYL)PROPIOLATE 5-TRIMETHYLSILYL-1-PENTEN-4-YN-3-OL 3-TRIMETHYLSILYLPROPARGYL ALDEHYDE DIETHYL ACETAL 2-HYDROXY-4-(TRIMETHYLSILYL)-3-BUTYNOIC ACID ETHYL ESTER 1-CYCLOHEXYL-3-(TERT-BUTYLDIMETHYLSILYL)-2-PROPYN-1-OL

3-TRIMETHYLSILYLPROPARGYL ALCOHOL, 98%3-TRIMETHYLSILYLPROPARGYL ALCOHOL, 98%3-TRIMETHYLSILYLPROPARGYL ALCOHOL, 98%

3-Trimethylsilyl-2-propyn-1-ol,99%

3-(triMethylsilyl)prop-2-yn-1-ol

3-Trimethylsilylpropargyl

3-(Trimethylsilyl)propargyl alcohol 99%

TIMTEC-BB SBB009061

TRIMETHYLSILYLPROPARGYL ALCOHOL

1-TRIMETHYLSILYLPROPARGYL ALCOHOL

3-(TRIMETHYLSILYL)PROPARGYL ALCOHOL

3-TRIMETHYLSILYL-2-PROPYN-1-OL

3-TRIMETHYLSILYL-2-PROPYNE-1-OL

3-TRIMETHYLSILANYL-PROP-2-YN-1-OL

2-Propyn-1-ol, 3-(trimethylsilyl)-

3-(trimethylsilyl)-2-propyn-1-o

3-Trimethylsilylpropargylalcohol3-Trimethylsilyl-2-propyn-1-ol

3-(Trimethylsilyl)propargyl alcohol, 98+%

3-TRIMETHYLSILYL-2-PROPYN-1-OL USP/EP/BP

3- (trimethylmethilyl) propanyl ol

DKSI027

Trimethylsilylpropynol

5272-36-6

CH33SiC8801CCH2OH

C6H12OSi

CH33SiCCCH2OH

Building Blocks

Alkynes

Ethynylsilanes

Silicon Compounds (for Synthesis)

Acetylenic Alcohols & Their Derivatives

Si-(C)4 Compounds

Acetylenes

Si (Classes of Silicon Compounds)

Organic Building Blocks

Internal

Acetylenic Alcohols & Their Derivatives

Ethynylsilanes

Si (Classes of Silicon Compounds)

Si-(C)4 Compounds

Silicon Compounds (for Synthesis)

Synthetic Organic Chemistry

Acetylenes