ChemicalBook > CAS DataBase List > 3-TRIMETHYLSILYL-2-PROPYN-1-OL

3-TRIMETHYLSILYL-2-PROPYN-1-OL

Product Name
3-TRIMETHYLSILYL-2-PROPYN-1-OL
CAS No.
5272-36-6
Chemical Name
3-TRIMETHYLSILYL-2-PROPYN-1-OL
Synonyms
3-(triMethylsilyl)prop-2-yn-1-ol;3-(TRIMETHYLSILYL)PROPARGYL ALCOHOL;3-TRIMETHYLSILANYL-PROP-2-YN-1-OL;3-Trimethylsilyl-2-propyn-1-ol,99%;2-Propyn-1-ol, 3-(trimethylsilyl)-;3-(Trimethylsilyl)propargyl alcohol 99%;DKSI027;TIMTEC-BB SBB009061;Trimethylsilylpropynol;3-Trimethylsilylpropargyl
CBNumber
CB2482992
Molecular Formula
C6H12OSi
Formula Weight
128.24
MOL File
5272-36-6.mol
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3-TRIMETHYLSILYL-2-PROPYN-1-OL Property

Melting point:
63.5-65.0 °C
Boiling point:
76 °C11 mm Hg(lit.)
Density 
0.865 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.451(lit.)
Flash point:
152 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Benzene (Sparingly)
pka
13.71±0.10(Predicted)
form 
Liquid
color 
Clear yellow
Specific Gravity
0.865
Water Solubility 
Not miscible with water.
Sensitive 
Moisture Sensitive
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
BRN 
1902505
InChIKey
ZVGCJDPEKKEYES-UHFFFAOYSA-N
CAS DataBase Reference
5272-36-6(CAS DataBase Reference)
NIST Chemistry Reference
3-Trimethylsilylpropargyl alcohol(5272-36-6)
EPA Substance Registry System
2-Propyn-1-ol, 3-(trimethylsilyl)- (5272-36-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
23-24/25-37/39-26
RIDADR 
2810
WGK Germany 
3
F 
8-10
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
318558
Product name
3-(Trimethylsilyl)propargyl alcohol
Purity
99%
Packaging
5g
Price
$66.9
Updated
2025/07/31
TCI Chemical
Product number
T1500
Product name
3-Trimethylsilyl-2-propyn-1-ol
Purity
>95.0%(GC)
Packaging
5mL
Price
$85
Updated
2025/07/31
GFS CHEMICALS
Product number
83533
Product name
3-TMSPROPARGYLALCOHOL
Packaging
250g
Price
$765.45
Updated
2021/12/16
TRC
Product number
T798175
Product name
TrimethylsilylpropargylAlcohol
Packaging
5g
Price
$180
Updated
2021/12/16
Activate Scientific
Product number
AS26021
Product name
3-Trimethylsilyl-2-propyn-1-ol
Purity
95+%
Packaging
25g
Price
$149
Updated
2021/12/16
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3-TRIMETHYLSILYL-2-PROPYN-1-OL Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Uses

Trimethylsilylpropargyl alcohol is used as a reagent to synthesize Isbogrel, a Thromboxane A 2 (TXA 2) synthase inhibitor and also a TXA 2 receptor antagonist that has potential to treat asthma.

Application

3-Trimethylsilyl-2-propyn-1-ol is a colourless transparent liquid which is sensitive to light, air and moisture, and can be used as raw material for organic synthesis or reaction reagent. Alkyllithiums undergo trans addition to 3-(trimethylsilyl)-2-propyn-1-ols to yield (1-lithiovinyl)silanes. Due to unidentified side-reactions, yields do not exceed 20%.

Synthesis

36551-06-1

5272-36-6

Compound 5 (0.250 g, 1.17 mmol) was added dropwise to a flask containing methanol (4.0 mL) and Amberlyst-15 (0.025 g) under nitrogen protection at a reaction temperature of 0 °C. The reaction mixture was warmed to 40 °C and stirred for 8 hours. Upon completion of the reaction, the resin was removed by filtration and washed with ethyl acetate (10 mL). To the filtrate, 10% aqueous hydrochloric acid (10 mL) was added, followed by extraction of the organic layer with ethyl acetate (3 x 10 mL). The organic phases were combined and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by column chromatography (eluent: hexane/ethyl acetate = 9:1) to afford compound 6 in 96% yield (0.143 g, 1.12 mmol).

References

[1] Tetrahedron, 1996, vol. 52, # 21, p. 7487 - 7510
[2] Journal of the Brazilian Chemical Society, 2013, vol. 24, # 12, p. 1933 - 1941
[3] Chemistry - A European Journal, 2015, vol. 21, # 27, p. 9662 - 9665
[4] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987, p. 1077 - 1082
[5] Journal of Organic Chemistry, 1995, vol. 60, # 14, p. 4650 - 4652

3-TRIMETHYLSILYL-2-PROPYN-1-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-TRIMETHYLSILYL-2-PROPYN-1-OL Suppliers

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View Lastest Price from 3-TRIMETHYLSILYL-2-PROPYN-1-OL manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3-TRIMETHYLSILYL-2-PROPYN-1-OL 5272-36-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-25
LY Global chemicals co.,ltd .
Product
3-TRIMETHYLSILYL-2-PROPYN-1-OL 5272-36-6
Price
US $0.00-0.00/g
Min. Order
10g
Purity
98%Min
Supply Ability
1000kg
Release date
2023-03-15
Dideu Industries Group Limited
Product
3-TRIMETHYLSILYL-2-PROPYN-1-OL 5272-36-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-05

5272-36-6, 3-TRIMETHYLSILYL-2-PROPYN-1-OLRelated Search:

Trifluoroacetamide SULFUR TRIOXIDE TRIMETHYLAMINE COMPLEX Boron trifluoride tetrahydrofuran complex METHYL 3-(TRIMETHYLSILYL)PROPIOLATE 3-TRIMETHYLSILYL-2-PROPYN-1-OL 4-TRIMETHYLSILYL-3-BUTYN-2-OL 2-METHYL-4-TRIMETHYLSILYL-3-BUTYN-2-OL 3-(TRIMETHYLSILYL)PROPIOLIC ACID 3-TERT-BUTYLDIMETHYLSILYL-2-PROPYN-1-OL Propyne Propargyl alcohol 3-METHYL-1-TRIMETHYLSILYL-1-PENTYN-3-OL (+/-) TRIMETHYLSILYL(TRIMETHYLSILYL)PROPYNOATE ETHYL 3-(TRIMETHYLSILYL)PROPIOLATE 5-TRIMETHYLSILYL-1-PENTEN-4-YN-3-OL 3-TRIMETHYLSILYLPROPARGYL ALDEHYDE DIETHYL ACETAL 2-HYDROXY-4-(TRIMETHYLSILYL)-3-BUTYNOIC ACID ETHYL ESTER 1-CYCLOHEXYL-3-(TERT-BUTYLDIMETHYLSILYL)-2-PROPYN-1-OL

  • 3-TRIMETHYLSILYLPROPARGYL ALCOHOL, 98%3-TRIMETHYLSILYLPROPARGYL ALCOHOL, 98%3-TRIMETHYLSILYLPROPARGYL ALCOHOL, 98%
  • 3-Trimethylsilyl-2-propyn-1-ol,99%
  • 3-(triMethylsilyl)prop-2-yn-1-ol
  • 3-Trimethylsilylpropargyl
  • 3-(Trimethylsilyl)propargyl alcohol 99%
  • TIMTEC-BB SBB009061
  • TRIMETHYLSILYLPROPARGYL ALCOHOL
  • 1-TRIMETHYLSILYLPROPARGYL ALCOHOL
  • 3-(TRIMETHYLSILYL)PROPARGYL ALCOHOL
  • 3-TRIMETHYLSILYL-2-PROPYN-1-OL
  • 3-TRIMETHYLSILYL-2-PROPYNE-1-OL
  • 3-TRIMETHYLSILANYL-PROP-2-YN-1-OL
  • 2-Propyn-1-ol, 3-(trimethylsilyl)-
  • 3-(trimethylsilyl)-2-propyn-1-o
  • 3-Trimethylsilylpropargylalcohol3-Trimethylsilyl-2-propyn-1-ol
  • 3-(Trimethylsilyl)propargyl alcohol, 98+%
  • 3-TRIMETHYLSILYL-2-PROPYN-1-OL USP/EP/BP
  • 3- (trimethylmethilyl) propanyl ol
  • DKSI027
  • Trimethylsilylpropynol
  • 5272-36-6
  • CH33SiC8801CCH2OH
  • C6H12OSi
  • CH33SiCCCH2OH
  • Building Blocks
  • Alkynes
  • Ethynylsilanes
  • Silicon Compounds (for Synthesis)
  • Acetylenic Alcohols & Their Derivatives
  • Si-(C)4 Compounds
  • Acetylenes
  • Si (Classes of Silicon Compounds)
  • Organic Building Blocks
  • Internal
  • Acetylenic Alcohols & Their Derivatives
  • Ethynylsilanes
  • Si (Classes of Silicon Compounds)
  • Si-(C)4 Compounds
  • Silicon Compounds (for Synthesis)
  • Synthetic Organic Chemistry
  • Acetylenes