ChemicalBook > CAS DataBase List > N-METHOXY-N-METHYLTRIFLUOROACETAMIDE

N-METHOXY-N-METHYLTRIFLUOROACETAMIDE

Product Name
N-METHOXY-N-METHYLTRIFLUOROACETAMIDE
CAS No.
104863-67-4
Chemical Name
N-METHOXY-N-METHYLTRIFLUOROACETAMIDE
Synonyms
2,2,2-trifluoro-N-Methoxy-N-MethylacetaMide;4-Methoxy-3-methylthiophenol;N-METHOXY-N-METHYLTRIFLUOROACETAMIDE;N-METHYL-N-METHOXYTRIFLUOROACETAMIDE;N-Methoxy-N-methyltrifluoroacetamide98%;N-Methoxy-N-methyltrifluoroacetamide 98%;N-METHOXY-N-METHYL-2,2,2-TRIFLUOROACETAMIDE;2,2,2-Trifluoro-N-methoxy-N-methylaetamdine;Acetamide, 2,2,2-trifluoro-N-methoxy-N-methyl-;N-Methoxy-N-methyl-2,2,2-trifluoroacetamide 98%
CBNumber
CB6695174
Molecular Formula
C4H6F3NO2
Formula Weight
157.09
MOL File
104863-67-4.mol
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N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Property

Boiling point:
53 °C/30 mmHg (lit.)
Density 
1.299 g/mL at 25 °C (lit.)
refractive index 
1.3630 to 1.3670
Flash point:
118 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Light yellow
InChI
InChI=1S/C4H6F3NO2/c1-8(10-2)3(9)4(5,6)7/h1-2H3
InChIKey
JDBJZZTZYKUFFK-UHFFFAOYSA-N
SMILES
C(N(OC)C)(=O)C(F)(F)F
CAS DataBase Reference
104863-67-4(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
10-25-36
Safety Statements 
16-26-45
RIDADR 
UN 1992 3/PG 3
WGK Germany 
3
HazardClass 
IRRITANT
PackingGroup 
III
HS Code 
2924190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
644153
Product name
N-Methoxy-N-methyl-2,2,2-trifluoroacetamide
Purity
98%
Packaging
5ml
Price
$75.52
Updated
2025/07/31
Sigma-Aldrich
Product number
644153
Product name
N-Methoxy-N-methyl-2,2,2-trifluoroacetamide
Purity
98%
Packaging
25ml
Price
$232.4
Updated
2025/07/31
TCI Chemical
Product number
T3326
Product name
2,2,2-Trifluoro-N-methoxy-N-methylacetamide
Purity
>98.0%(GC)
Packaging
5g
Price
$66
Updated
2025/07/31
TCI Chemical
Product number
T3326
Product name
2,2,2-Trifluoro-N-methoxy-N-methylacetamide
Purity
>98.0%(GC)
Packaging
25g
Price
$198
Updated
2025/07/31
TRC
Product number
M271688
Product name
N-Methoxy-N-methyltrifluoroacetamide
Packaging
5g
Price
$75
Updated
2021/12/16
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N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Synthesis

6638-79-5

407-25-0

104863-67-4

To a suspension of N,O-dimethylhydroxylamine hydrochloride (107.2 kg, 1.1 kmol) in dichloromethane (400 L) was sequentially added trifluoroacetic anhydride (210 kg, 1 kmol) and pyridine (174 kg, 2.2 kmol) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, the reaction solution was diluted with ice water (300 L) and washed with 2M hydrochloric acid (300 L). The aqueous phase was extracted twice with dichloromethane, the organic phases were combined and dried with anhydrous magnesium sulfate. After concentration of the organic phase, the crude N-methoxy-N-methyl-2,2,2-trifluoroacetamide (Weinreb amide) was obtained with 90% purity and 95% yield, which could be used in the subsequent reaction without further purification.

References

[1] Asian Journal of Chemistry, 2015, vol. 27, # 7, p. 2406 - 2408
[2] Journal of Organic Chemistry, 1991, vol. 56, # 13, p. 4260 - 4263
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7887 - 7896
[4] Patent: WO2003/101932, 2003, A2. Location in patent: Page 64
[5] Patent: WO2003/82787, 2003, A1. Location in patent: Page/Page column 108

N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-METHOXY-N-METHYLTRIFLUOROACETAMIDE Suppliers

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View Lastest Price from N-METHOXY-N-METHYLTRIFLUOROACETAMIDE manufacturers

Career Henan Chemical Co
Product
N-METHOXY-N-METHYLTRIFLUOROACETAMIDE 104863-67-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-06

104863-67-4, N-METHOXY-N-METHYLTRIFLUOROACETAMIDERelated Search:

N-Methoxy-N-Methyltetrahydropyran-4-carboxaMide N-Methyl-2,2,2-trifluoroacetamide N-METHYL-N-METHOXYDIFLUOROACETAMIDE N-METHOXY-N-METHYLTRIFLUOROACETAMIDE

  • N-METHYL-N-METHOXYTRIFLUOROACETAMIDE
  • N-METHOXY-N-METHYLTRIFLUOROACETAMIDE
  • N-METHOXY-N-METHYL-2,2,2-TRIFLUOROACETAMIDE
  • N-Methoxy-N-methyltrifluoroacetamide 98%
  • N-Methoxy-N-methyltrifluoroacetamide98%
  • 4-Methoxy-3-methylthiophenol
  • N-Methoxy-N-methyl-2,2,2-trifluoroacetamide 98%
  • N-Methoxy-N-(trifluoroacetyl)methylamine, N-Methoxy-N-methyl-2,2,2-trifluoroacetamide
  • 2,2,2-trifluoro-N-Methoxy-N-MethylacetaMide
  • N-Methoxy-N-methyl-2,2,2-trifluoroacetamide≥ 98%(GC)
  • N-Methoxy-N-(trifluoroacetyl)methylamine, N-Methoxy-N-methyl
  • Acetamide, 2,2,2-trifluoro-N-methoxy-N-methyl-
  • 104863-67-4 C4H6F3NO2 N-METHOXY-N-METHYLTRIFLUOROACETAMIDE
  • <i>N</i>-Methoxy-<i>N</i>-methyl-2,2,2-trifluoroacetamide
  • 2,2,2-Trifluoro-N-methoxy-N-methylaetamdine
  • 104863-67-4
  • Carbonyl Compounds
  • Amides
  • Building Blocks
  • Organic Building Blocks