3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-

ChemicalBook > CAS DataBase List > 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-

3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-

Product Name: 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-
CAS No.: 1033836-12-2
Chemical Name: 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-
Synonyms: CS-1438;MDK36122;HPGDS inhibitor 1;HPGDS inhibitor 1, >=98%;Prostaglandin D Synthase (hematopoietic-type) Inhibitor I;6-(3-fluorophenyl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)nicotinaMide;6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-3-pyridinecarboxamide;3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-
CBNumber: CB22599009
Molecular Formula: C19H19F4N3O
Formula Weight: 381.37
MOL File: 1033836-12-2.mol

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3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]- Property

Boiling point:: 487.2±45.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
form: crystalline solid
pka: 9.55±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16256
Product name: Prostaglandin D Synthase (hematopoietic-type) Inhibitor I
Purity: ≥98%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 16256
Product name: Prostaglandin D Synthase (hematopoietic-type) Inhibitor I
Purity: ≥98%
Packaging: 5mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 16256
Product name: Prostaglandin D Synthase (hematopoietic-type) Inhibitor I
Purity: ≥98%
Packaging: 10mg
Price: $543
Updated: 2024/03/01

Biorbyt Ltd

Product number: orb181253
Product name: HPGDS-inhibitor-1
Purity: >98%
Packaging: 100mg
Price: $765
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb181253
Product name: HPGDS-inhibitor-1
Purity: >98%
Packaging: 250mg
Price: $1504.5
Updated: 2021/12/16

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3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]- Chemical Properties,Usage,Production

Biological Activity

hpgds inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin d synthase (hpgds) with ic50 value of 0.7nm [1].prostaglandin d2 (pgd2) is a mediator of allergy and inflammation. it is isomerized from pgh2 by pgds. this production is important in airway allergic and inflammatory processes. hpgds inhibitor 1 has a 3-fluorine substituent, making it stable in the in vitro human microsome assay. it has potent effects in enzyme assay and cellular assay with ic50 values of 0.7nm and 32nm, respectively. in addition, the potency is equal against purified hpgds from various species with ic50 values ranging from 0.5-2.3nm. besides that, hpgds inhibitor 1 is selective against hpgds over other relevant human enzymes including l-pgds, mpges, cox-1, cox-2 and 5 lox [1].in a model of antigen-induced airway response in allergic sheep, treatment of hpgds inhibitor 1 completely prevents the late asthma reaction and blocks the airway hyper-responsiveness [1].

in vitro

HPGDS inhibitor 1 has equal potency against purified HPGDS from human, rat, dog, and sheep (IC ₅₀ , 0.5-2.3 nM).

in vivo

HPGDS inhibitor 1 (compound 8; 1 mg/kg) has excellent PK characteristics with 76% bioavailability, and the T _1/2 is 4.1 hours in rats.
Rats dosed orally with 1 mg/kg and 10 mg/kg HPGDS inhibitor 1 (compound 8) are sacrificed at various times. Oral administration of it blocks PGD2 production in the rat spleen; inhibition of PGD2 is inversely correlated with the plasma concentration of it in a time- and dose-dependent manner.
It (compound 8; 1 mg/mL) illustrates efficacy in an in vivo sheep model of asthma.

target

IC50: 0.6 nM (HPGDS in enzyme assays) and 32 nM (HPGDS in cellular assays)

References

[1] carron c p, trujillo j i, olson k l, et al. discovery of an oral potent selective inhibitor of hematopoietic prostaglandin d synthase (hpgds). acs medicinal chemistry letters, 2010, 1(2): 59-63.

3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]- manufacturers

Career Henan Chemical Co

Product: 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]- 1033836-12-2
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-24

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