ChemicalBook > CAS DataBase List > 4,6-dichloro-3-nitropyridin-2-aMine
4,6-dichloro-3-nitropyridin-2-aMine
Uses- Product Name
- 4,6-dichloro-3-nitropyridin-2-aMine
- CAS No.
- 37660-64-3
- Chemical Name
- 4,6-dichloro-3-nitropyridin-2-aMine
- Synonyms
- 4,6-Dichloro-3-nitro-2-pyridinamine;4,6-dichloro-3-nitropyridin-2-aMine;2-Pyridinamine, 4,6-dichloro-3-nitro-;2-AMino-4,6-dichloro-3-nitro-pyridine
- CBNumber
- CB22606095
- Molecular Formula
- C5H3Cl2N3O2
- Formula Weight
- 208
- MOL File
- 37660-64-3.mol
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4,6-dichloro-3-nitropyridin-2-aMine Property
- Boiling point:
- 366.1±37.0 °C(Predicted)
- Density
- 1.723±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -2.71±0.50(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C5H3Cl2N3O2/c6-2-1-3(7)9-5(8)4(2)10(11)12/h1H,(H2,8,9)
- InChIKey
- JHRWWIQRZCVYJZ-UHFFFAOYSA-N
- SMILES
- C1(N)=NC(Cl)=CC(Cl)=C1[N+]([O-])=O
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- D439288
- Product name
- 4,6-Dichloro-3-nitropyridin-2-amine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0365361
- Product name
- 4,6-DICHLORO-3-NITROPYRIDIN-2-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.81
- Updated
- 2021/12/16
Chemenu
- Product number
- CM175657
- Product name
- 4,6-dichloro-3-nitropyridin-2-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $688
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11133163
- Product name
- 4,6-Dichloro-3-nitropyridin-2-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $728
- Updated
- 2021/12/16
Ambeed
- Product number
- A137681
- Product name
- 4,6-Dichloro-3-nitropyridin-2-amine
- Purity
- 97%
- Packaging
- 5g
- Price
- $830
- Updated
- 2021/12/16
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4,6-dichloro-3-nitropyridin-2-aMine Chemical Properties,Usage,Production
Uses
4,6-Dichloro-3-nitropyridin-2-amine is a reagent used in the preparation of mTOR inhibitors.
Uses
4,?6-?Dichloro-?3-?nitropyridin-?2-?amine is a reagent used in the preparation of mTOR inhibitors.
Synthesis
116632-24-7
37660-64-3
General procedure for the synthesis of 4,6-dichloro-3-nitro-2-pyridinamine from 2-amino-4,6-dichloropyridine: 2-amino-4,6-dichloropyridine (4.48 g, 27.48 mmol) was added in batches to concentrated sulfuric acid (6 mL) and fuming nitric acid (1.2 mL) was added slowly and dropwise at 5 °C. The reaction mixture was stirred continuously for 10 h at 5 °C. After completion of the reaction, the reaction was quenched with ice water and the pH was adjusted to 7 to give 3.55 g of yellow solid 4,6-dichloro-3-nitro-2-pyridinamine washed with methanol (yield: 62.1%). Melting point: 208°C. 1H-NMR (300MHz, CDCl3), δ (ppm): 6.84 (s, 1H), 6.25 (br, 2H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3395 - 3398
[2] Patent: WO2014/128465, 2014, A1. Location in patent: Page/Page column 102
[3] Patent: WO2018/75937, 2018, A1. Location in patent: Paragraph 00317; 00318; 00588
4,6-dichloro-3-nitropyridin-2-aMine Preparation Products And Raw materials
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View Lastest Price from 4,6-dichloro-3-nitropyridin-2-aMine manufacturers
Career Henan Chemical Co
- Product
- 4,6-dichloro-3-nitropyridin-2-aMine 37660-64-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16