ChemicalBook > CAS DataBase List > BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-

BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-

Product Name: BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-
CAS No.: 300586-90-7
Chemical Name: BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-
Synonyms: OAC1;CS-2147;OAC1, >98%;OAC1;OAC-1;OAC1 ，S7217;BAS 00287861;OAC1;OAC-1;OAC 1;OAC1 (BAS 00287861);OAC1, 10 mM in DMSO;OAC1;OAC-1;OAC 1;BAS 00287861
CBNumber: CB22608044
Molecular Formula: C14H11N3O
Formula Weight: 237.26
MOL File: 300586-90-7.mol

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BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- Property

Boiling point:: 386.6±22.0 °C(Predicted)
Density: 1.363±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
pka: 11.76±0.43(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3
HS Code: 2933.99.8290

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0651
Product name: OAC1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $101
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.00501
Product name: iPSC Induction Enhancer II, OAC1 - CAS 300586-90-7 - Calbiochem
Packaging: 25MG
Price: $246
Updated: 2023/01/07

Sigma-Aldrich

Product number: SML0651
Product name: OAC1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $428
Updated: 2022/05/15

TCI Chemical

Product number: O0490
Product name: OAC1
Purity: >98.0%(GC)
Packaging: 10mg
Price: $134
Updated: 2025/07/31

TCI Chemical

Product number: O0490
Product name: OAC1
Purity: >98.0%(GC)
Packaging: 50mg
Price: $402
Updated: 2025/07/31

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BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- Chemical Properties,Usage,Production

Uses

OAC1 enhances iPSC reprogramming efficiency.

General Description

A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1 μM OAC1 treatment starts 48 h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294 (Cat. No. 382190), Tranylcypromine (Cat. No. 616431), VPA (Cat. No. 676380), and Vitamin C (Cat. No. 1813), in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO (Cat. No. 361550) is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: yes

in vivo

OAC1 (50000 CB CD34⁺ cells with OAC1(500 nM); i.h.; 16 weeks) enhances short and long-term engrafting hematopoietic stem cells (HSC) in irradiated NSG mice^[2].

Animal Model:	Irradiated NSG mice with OAC1 or vehicle control treated CB CD34⁺ cells within 24h after irradiation^[2]
Dosage:	16 weeks
Administration:	Subcutaneous injection OAC1(500 nM) treated CB CD34⁺ cells
Result:	Increased cord blood (CB) cells in primary recipients, compared to the vehicle control group, with the board increase for human B cells, T cells, and myeloid cells in the bone marrow (BM) of primary recipients, resulting in a significant expansion of SRC numbers.

IC 50

TET1

storage

+4°C

BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- manufacturers

Career Henan Chemical Co

Product: BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- 300586-90-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week 100kg
Release date: 2019-09-05

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Inhibitors