Nepicastat hydrochloride
- Product Name
- Nepicastat hydrochloride
- CAS No.
- 170151-24-3
- Chemical Name
- Nepicastat hydrochloride
- Synonyms
- SYN-117 HCl;Nepicastat HCl, >=99%;SYN-117 hydrochloride;Nepicastat (SYN117)HCI;NEPICASTAT HYDROCHLORIDE;Nepicastat HCl (SYN-117);Nepicastat (SYN-117) HCl;RS-25560-197 hydrochloride);Nepicastat (SYN-117) hydrochloride;Nepicastat hydrochloride USP/EP/BP
- CBNumber
- CB22611129
- Molecular Formula
- C14H16ClF2N3S
- Formula Weight
- 331.81
- MOL File
- 170151-24-3.mol
Nepicastat hydrochloride Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- color
- white to beige
- InChIKey
- DIPDUAJWNBEVOY-PPHPATTJSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0940
- Product name
- Nepicastat hydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- SML0940
- Product name
- Nepicastat hydrochloride
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $462
- Updated
- 2024/03/01
- Product number
- 22126
- Product name
- Nepicastat (hydrochloride)
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 22126
- Product name
- Nepicastat (hydrochloride)
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 22126
- Product name
- Nepicastat (hydrochloride)
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
Nepicastat hydrochloride Chemical Properties,Usage,Production
Description
Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH; IC50 = 9 nM for the purified human enzyme). It is selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM). Nepicastat dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs. It attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats when administered orally at doses of 10 and 30 mg/kg. Nepicatstat (50 mg/kg) reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats. It also reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine , or foot-shock in rats.
Uses
Nepicastat Hydrochloride is a potent and selective dopamine β-hydrolase inhibitor. Used in cardiovascular treatment where deficiencies in ventricles results in heart failure.
storage
Store at -20°C
References
[1]. stanley wc, li b, bonhaus dw, et al. catecholamine modulatory effects of nepicastat (rs-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. br j pharmacol, 1997, 121(8): 1803-1809.
[2]. stanley wc, lee k, johnson lg, et al. cardiovascular effects of nepicastat (rs-25560-197), a novel dopamine beta-hydroxylase inhibitor. j cardiovasc pharmacol, 1998, 31(6): 963-970.
[3]. devoto p, flore g, saba p, et al. the dopamine beta-hydroxylase inhibitor nepicastat increases dopamine release and potentiates psychostimulant-induced dopamine release in the prefrontal cortex. addict biol, 2014, 19(4): 612-622.
Nepicastat hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nepicastat hydrochloride manufacturers
- Product
- Nepicastat HCl 170151-24-3
- Price
- US $50.00/KG
- Min. Order
- 1Kg/Bag
- Purity
- 99.99%
- Supply Ability
- 20 tons/month
- Release date
- 2021-04-19
- Product
- Nepicastat hydrochloride 70151-24-3
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2020-01-08