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Nepicastat hydrochloride

Product Name
Nepicastat hydrochloride
CAS No.
170151-24-3
Chemical Name
Nepicastat hydrochloride
Synonyms
SYN-117 HCl;Nepicastat HCl, >=99%;SYN-117 hydrochloride;Nepicastat (SYN117)HCI;NEPICASTAT HYDROCHLORIDE;Nepicastat HCl (SYN-117);Nepicastat (SYN-117) HCl;RS-25560-197 hydrochloride);Nepicastat (SYN-117) hydrochloride;Nepicastat hydrochloride USP/EP/BP
CBNumber
CB22611129
Molecular Formula
C14H16ClF2N3S
Formula Weight
331.81
MOL File
170151-24-3.mol
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Nepicastat hydrochloride Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
color 
white to beige
InChIKey
DIPDUAJWNBEVOY-PPHPATTJSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0940
Product name
Nepicastat hydrochloride
Purity
≥95% (HPLC)
Packaging
5mg
Price
$115
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0940
Product name
Nepicastat hydrochloride
Purity
≥95% (HPLC)
Packaging
25mg
Price
$462
Updated
2024/03/01
Cayman Chemical
Product number
22126
Product name
Nepicastat (hydrochloride)
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
22126
Product name
Nepicastat (hydrochloride)
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
22126
Product name
Nepicastat (hydrochloride)
Packaging
10mg
Price
$176
Updated
2024/03/01
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Nepicastat hydrochloride Chemical Properties,Usage,Production

Description

Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH; IC50 = 9 nM for the purified human enzyme). It is selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM). Nepicastat dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs. It attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats when administered orally at doses of 10 and 30 mg/kg. Nepicatstat (50 mg/kg) reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats. It also reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine , or foot-shock in rats.

Uses

Nepicastat Hydrochloride is a potent and selective dopamine β-hydrolase inhibitor. Used in cardiovascular treatment where deficiencies in ventricles results in heart failure.

storage

Store at -20°C

References

[1]. stanley wc, li b, bonhaus dw, et al. catecholamine modulatory effects of nepicastat (rs-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. br j pharmacol, 1997, 121(8): 1803-1809.
[2]. stanley wc, lee k, johnson lg, et al. cardiovascular effects of nepicastat (rs-25560-197), a novel dopamine beta-hydroxylase inhibitor. j cardiovasc pharmacol, 1998, 31(6): 963-970.
[3]. devoto p, flore g, saba p, et al. the dopamine beta-hydroxylase inhibitor nepicastat increases dopamine release and potentiates psychostimulant-induced dopamine release in the prefrontal cortex. addict biol, 2014, 19(4): 612-622.

Nepicastat hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Nepicastat hydrochloride Suppliers

China 82 India 1 United Kingdom 2 United States 19 Global 104
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from Nepicastat hydrochloride manufacturers

Wuhan Monad Medicine Tech Co.,LTD
Product
Nepicastat HCl 170151-24-3
Price
US $50.00/KG
Min. Order
1Kg/Bag
Purity
99.99%
Supply Ability
20 tons/month
Release date
2021-04-19
Career Henan Chemical Co
Product
Nepicastat hydrochloride 70151-24-3
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

170151-24-3, Nepicastat hydrochlorideRelated Search:

Disulfiram

  • NEPICASTAT HYDROCHLORIDE
  • Nepicastat HCl (SYN-117),Nepicastat hydrochloride,
  • Nepicastat (SYN-117) HCl
  • Nepicastat HCl (SYN-117)
  • 4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione
  • (S)-5-(AMinoMethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-iMidazole-2(3H)-thione hydrochloride
  • Nepicastat (SYN117)HCI
  • RS 25560-197 Nepicastat hydrochloride
  • 5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride
  • 5-(Aminomethyl)-1-[5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2(S)-yl]-2,3-dihydro-1H-imidazole-2-thione hydrochloride
  • Nepicastat HCl, >=99%
  • (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1H-imidazole-2(3H)-thio
  • Nepicastat (SYN-117) hydrochloride
  • Nepicastat Hydrochloride (SYN-117 hydrochloride
  • RS-25560-197 hydrochloride)
  • SYN-117 HCl
  • SYN-117 hydrochloride
  • SYN-117 HYDROCHLORIDE;RS-25560-197 HYDROCHLORIDE
  • Nepicastat hydrochloride USP/EP/BP
  • 4-(aminomethyl)-3-[(2S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-1H-imidazole-2-thione,hydrochloride
  • 2H-Imidazole-2-thione,5-(aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-,hydrochloride (1:1)
  • (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride
  • Dopamine beta-monooxygenase,Dopamine beta-hydroxylase,Dopamine β-monooxygenase,Nepicastat hydrochloride,Nepicastat,SYN117,SYN-117,Dopamine β-hydroxylase,Inhibitor,SYN 117,inhibit
  • 170151-24-3
  • 70151-24-3
  • C14H15F2N3SHCl
  • C14H16ClF2N3S
  • C14H15F2N3SClH
  • Inhibitors
  • Inhibitor