TFA-ap-dC

Product Name: TFA-ap-dC
CAS No.: 115899-38-2
Chemical Name: TFA-ap-dC
Synonyms: TFA-ap-dC;5-TFA-ap-dC;5-TFA-ap-2-Deoxycytidine;5-TFA-ap-2'-deoxycytidine;2'-Deoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]cytidine;5-[3-(2,2,2-trifluoroacetamido)-prop-1-ynyl]-2'-deoxycytidine;2'-Deoxy-5-[3-[(trifluoroacetyl)amino]-1-propyn-1-yl]-cytidine;Cytidine, 2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]...;05-[3-(2,2,2-trifluoroa cetamido)-prop-1-yn yl]-2'-deoxycytidine;Cytidine, 2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propyn-1-yl]-
CBNumber: CB22614115
Molecular Formula: C14H15F3N4O5
Formula Weight: 376.29
MOL File: 115899-38-2.mol

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TFA-ap-dC Property

Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.24±0.46(Predicted)
Appearance: White to yellow Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 5127CV
Product name: TFA-ap-dC
Packaging: 250mg
Price: $193
Updated: 2021/12/16

Ark Pharm

Product number: P000083630
Product name: TFA-ap-dC
Purity: 97%
Packaging: 1g
Price: $220
Updated: 2021/12/16

Activate Scientific

Product number: AS112077
Product name: TFA-ap-dC
Purity: 97%
Packaging: 100mg
Price: $298
Updated: 2021/12/16

AK Scientific

Product number: 5127CV
Product name: TFA-ap-dC
Packaging: 1g
Price: $384
Updated: 2021/12/16

Activate Scientific

Product number: AS112077
Product name: TFA-ap-dC
Purity: 97%
Packaging: 250mg
Price: $495
Updated: 2021/12/16

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TFA-ap-dC Chemical Properties,Usage,Production

Synthesis

14719-21-2

611-53-0

115899-38-2

Under argon protection, 5-iodo-2'-deoxycytidine (10 g, 28.32 mmol) was dissolved in DMF (200 mL) in a light protected round bottom flask. CuI (1.08 g, 5.67 mmol), triethylamine (7.80 mL, 55.60 mmol), 2,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide (12.8 g, 84.76 mmol), and Pd(PPh3)4 (3.27 g, 2.83 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 18 hours. Subsequently, sodium bicarbonate (20 mg) was added and stirring was continued for 1 hour. After completion of the reaction, the crude product was obtained by filtration under reduced pressure and concentration to remove the volatile solvent. Purification by silica gel fast column chromatography (elution gradient: CH2Cl2, CH2Cl2:EtOAc 1:1, EtOAc:MeOH 9:1) afforded the target compound N-(3-(4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuryl-2- yl)-2-oxo-1,2-dihydropyrimidin-5-yl)propane- 2-yn-1-yl)-2,2,2-trifluoroacetamide (7) as a beige solid in quantitative yield.1H NMR (D2O) δ 2.24-2.17 (m, 1H, H-2'), 2.41-2.37 (m, 1H, H-2'), 3.68 (dd, J = 12.5, 5.0 Hz, 1H, H-5'), 3.77 (dd, J = 12.5, 3.2 Hz, 1H, H-5'), 3.99 (m, 1H, H-4'), 4.27 (s, 2H, CH2N), 4.34 (m, 1H, H-3'), 6.11 (t, J = 6.3 Hz, 1H, H-1'), 8.1 (br s, 1H, NH); MS (ES): m/z (%) (M-H) 375 (100).

References

[1] Patent: EP2607369, 2015, B1. Location in patent: Paragraph 0138
[2] Chemical Communications, 2005, # 36, p. 4551 - 4553
[3] Patent: WO2016/182984, 2016, A1. Location in patent: Paragraph 00140
[4] Journal of the American Chemical Society, 2005, vol. 127, # 43, p. 15071 - 15082
[5] Patent: CN104693258, 2017, B. Location in patent: Paragraph 0088; 0094; 0095

TFA-ap-dC Preparation Products And Raw materials

Raw materials

Preparation Products

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TFA-ap-dC Suppliers

China 47 India 1 United States 2 Global 50

Wuhu Huaren Science and Technology Co., Ltd.

Tel: 0553-5842013-801 18155347026
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Finetech Industry Limited

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Wuhu Nuowei Chemical Technology Co., Ltd

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Shanghai Haozhixiang Biotechnology Co., Ltd

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BePharm Ltd

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Email: market@bepharm.com
Country: China
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Amadis Chemical Company Limited

Tel: 571-89925085
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Email: sales@amadischem.com
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Aikon International Limited

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Fax: (3)02557626880
Email: qqyang@aikonchem.com
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Maanshan geneyan biotech Co.,LTD

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd.

Tel: 0755-23251735 13302967066
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View Lastest Price from TFA-ap-dC manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: TFA-ap-dC 115899-38-2
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 2000
Release date: 2025-06-03

WUHAN FORTUNA CHEMICAL CO., LTD

Product: TFA-ap-dC 115899-38-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2021-09-01

Henan Aochuang Chemical Co.,Ltd.

Product: TFA-ap-dC 115899-38-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-23

115899-38-2, TFA-ap-dCRelated Search:

TFA-ap-dU TFA-aa-dC 7-DEAZA-7-IODO-2'-DEOXYADENOSINE 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE 2',3'-DIDEOXYADENOSINETRIPHOSPHORICACID=DDATP 2',3'-dideoxycytidine 5'-triphosphate

2'-Deoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]cytidine

5-TFA-ap-2-Deoxycytidine

5-TFA-ap-dC

2'-Deoxy-5-[3-[(trifluoroacetyl)amino]-1-propyn-1-yl]-cytidine

TFA-ap-dC

Cytidine, 2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propyn-1-yl]-

Cytidine, 2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]...

N-(3-(4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-5-yl)prop-2-yn-1-yl)-2,2,2-trifluoroacetamide

5-TFA-ap-2'-deoxycytidine

5-[3-(2,2,2-trifluoroacetamido)-prop-1-ynyl]-2'-deoxycytidine

05-[3-(2,2,2-trifluoroa cetamido)-prop-1-yn yl]-2'-deoxycytidine

115899-38-2

C14H15F3N4O5