TFA-ap-dU

Product Name: TFA-ap-dU
CAS No.: 115899-40-6
Chemical Name: TFA-ap-dU
Synonyms: TFA-ap-dU;5-TFA-AP-DU;5-TFA-ap-dU 5-TFA-ap-dU;5-TFA-ap-2'-deoxyuridine;2'-deoxy-5-[3-(trifluoroacetyl)amino]-1-propynyl]uridine;Uridine, 2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]-;2'-Deoxy-5-[3-[(2,2,2-trifluoroacetyl)aMino]-1-propyn-1-yl]uridine;Uridine, 2'-deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]-
CBNumber: CB62723406
Molecular Formula: C14H14F3N3O6
Formula Weight: 377.27
MOL File: 115899-40-6.mol

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TFA-ap-dU Property

Melting point:: >116°C (dec.)
Density: 1?+-.0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 8.17±0.10(Predicted)
form: Solid
color: Pale Yellow to Light Orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D282515
Product name: 2''-Deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]uridine
Packaging: 250mg
Price: $150
Updated: 2021/12/16

TRC

Product number: D282515
Product name: 2''-Deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]uridine
Packaging: 2.5g
Price: $1190
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 50632
Product name: 2??-Deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]uridine
Packaging: 2.5g
Price: $2200
Updated: 2021/12/16

Ark Pharm

Product number: P000083631
Product name: TFA-ap-dU
Purity: 97%
Packaging: 1g
Price: $2378
Updated: 2021/12/16

Ark Pharm

Product number: P000083631
Product name: TFA-ap-dU
Purity: 97%
Packaging: 250mg
Price: $951
Updated: 2021/12/16

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TFA-ap-dU Chemical Properties,Usage,Production

Uses

2''-Deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]uridine is an intermediate in the synthesis of fluorescent labeling compounds of cyclooctyne-modified deoxyuridine triphosphates in DNA.

Synthesis

14719-21-2

54-42-2

115899-40-6

To a solution of 5-iodouridine (5.0 g, 14.1 mmol) in anhydrous DMF (40 mL), CuI (0.20 g, 1.05 mmol) and Pd(PPh3)4 (0.41 g, 0.35 mmol) were added under nitrogen protection. After stirring for 10 min, triethylamine (4.0 mL, 28.6 mmol) and 2,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide (5.4 g, 35.7 mmol) were added sequentially and the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, all volatiles were removed under vacuum and the residue was purified by rapid chromatography on silica gel [eluent: EtOAc/MeOH (0-15%)] to afford the target product 2,2,2-trifluoro-N-(3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4- (tetrahydropyrimidin-5-yl)prop-2-ynyl)acetamide as a yellow solid (4.1 g, 76% yield).1H-NMR (DMSO-d6) δ: 11.68 (br s, 1H, NH), 10.02 (s, 1H, NH), 7.94 (s, 1H, H-6), 6.11 (t, J = 7.2 Hz, H-1'), 5.29 (d, J = 0.4 Hz, NH), 6.11 (t, J = 0.4 Hz, NH), 5.29 (d, J = 0.4 Hz, NH). J = 0.4 Hz, 1H, OH), 4.21 (m, 3H, H-3', NCH2), 3.71-3.83 (m, 2H, CH2-5'), 2.15-2.19 (m, 1H, H-2'), 2.03-2.08 (m, 1H, H-2'). Mass Spectra (ESI): Calculated value C14H14F3N3O6 (M + Na)+ 400, measured value 400.

References

[1] Tetrahedron, 2009, vol. 65, # 4, p. 934 - 939
[2] Journal of the American Chemical Society, 2005, vol. 127, # 43, p. 15071 - 15082
[3] Helvetica Chimica Acta, 2007, vol. 90, # 6, p. 1082 - 1098
[4] Journal of the American Chemical Society, 2011, vol. 133, # 8, p. 2463 - 2480
[5] Helvetica Chimica Acta, 2008, vol. 91, # 1, p. 165 - 175

TFA-ap-dU Preparation Products And Raw materials

Raw materials

Preparation Products

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TFA-ap-dU Suppliers

China 33 India 1 United States 3 Global 37

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Wuhu Nuowei Chemical Technology Co., Ltd

Tel: 0553-0553-8233716-803-803 18055326116
Email: sales@nuowei-chem.com
Country: China
ProdList: 953
Advantage: 55

BePharm Ltd

Tel: 400-685-9117
Fax: 021-51816740
Email: market@bepharm.com
Country: China
ProdList: 15081
Advantage: 60

WG reagent

Tel: 13391486464
Fax: QQ:14748090
Email: samwjf@163.com
Country: China
ProdList: 3086
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Maanshan geneyan biotech Co.,LTD

Tel: 18913822354
Email: market@geneyan-bio.com
Country: China
ProdList: 300
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd.

Tel: 0755-23251735 13302967066
Email: sales@geneseqtools.com
Country: China
ProdList: 1420
Advantage: 58

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View Lastest Price from TFA-ap-dU manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: TFA-ap-dU 115899-40-6
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 98%
Supply Ability: 2000
Release date: 2025-06-03

WUHAN FORTUNA CHEMICAL CO., LTD

Product: TFA-ap-dU 115899-40-6
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2021-09-02

115899-40-6, TFA-ap-dURelated Search:

TFA-aa-dC TFA-ap-dC 7-DEAZA-7-IODO-2'-DEOXYADENOSINE 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE 2',3'-DIDEOXYADENOSINETRIPHOSPHORICACID=DDATP 2',3'-dideoxycytidine 5'-triphosphate

TFA-ap-dU

2'-Deoxy-5-[3-[(2,2,2-trifluoroacetyl)aMino]-1-propyn-1-yl]uridine

5-TFA-AP-DU

5-TFA-ap-dU 5-TFA-ap-dU

Uridine, 2'-deoxy-5-[3-[(trifluoroacetyl)amino]-1-propynyl]-

Uridine, 2'-deoxy-5-[3-[(2,2,2-trifluoroacetyl)amino]-1-propyn-1-yl]-

2'-deoxy-5-[3-(trifluoroacetyl)amino]-1-propynyl]uridine

5-TFA-ap-2'-deoxyuridine

115899-40-6