4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester

Product Name: 4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester
CAS No.: 1093759-59-1
Chemical Name: 4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester
Synonyms: 1-Boc-4-methoxyindole;Tert-butyl 4-methoxyindole-1-carboxylate;4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester;1H-Indole-1-carboxylic acid, 4-methoxy-, 1,1-dimethylethyl ester
CBNumber: CB22614377
Molecular Formula: C14H17NO3
Formula Weight: 247.29
MOL File: 1093759-59-1.mol

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4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester Property

Boiling point:: 357.3±34.0 °C(Predicted)
Density: 1.10
storage temp.: Sealed in dry,Store in freezer, under -20°C
Appearance: Colorless to light pink Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B700798
Product name: tert-Butyl4-Methoxy-1H-indole-1-carboxylate
Packaging: 1g
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: 1841AA
Product name: tert-Butyl4-methoxy-1H-indole-1-carboxylate
Packaging: 250mg
Price: $140
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0143220
Product name: N-BOC-4-METHOXYINDOLE
Purity: 95.00%
Packaging: 5MG
Price: $498.32
Updated: 2021/12/16

AK Scientific

Product number: 1841AA
Product name: tert-Butyl4-methoxy-1H-indole-1-carboxylate
Packaging: 5g
Price: $729
Updated: 2021/12/16

Alichem

Product number: 1093759591
Product name: tert-Butyl4-methoxy-1H-indole-1-carboxylate
Packaging: 5g
Price: $533.18
Updated: 2021/12/16

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4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

4837-90-5

24424-99-5

1093759-59-1

General procedure for the synthesis of N-Boc-4-methoxyindole from 4-methoxyindole and di-tert-butyl dicarbonate: 1.6 g of 4-methoxyindole was dissolved in 20 mL of acetonitrile, followed by the addition of 2.6 g of di-tert-butyl dicarbonate and 0.03 g of 4-dimethylaminopyridine (DMAP). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was poured into a pH 2 buffer solution and extracted with ethyl acetate (EtOAc). The organic phase was washed with saturated sodium chloride (NaCl) solution and dried over anhydrous magnesium sulfate (MgSO4). After concentration under reduced pressure to remove the solvent, the residue was purified by silica gel column chromatography using a gradient elution of cyclohexane/ethyl acetate (98/2 v/v to 95/5 v/v). 2.4 g of N-Boc-4-methoxyindole was finally obtained.

References

[1] Angewandte Chemie, International Edition, 2009, vol. 48, # 23, p. 4235 - 4238
[2] Tetrahedron, 2009, vol. 65, # 34, p. 6877 - 6881
[3] Synthesis, 2009, # 21, p. 3617 - 3632
[4] Patent: WO2007/147874, 2007, A1. Location in patent: Page/Page column 148-149
[5] Patent: WO2011/28580, 2011, A1. Location in patent: Page/Page column 19; 20

4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methoxy-1H-indole-1-carboxylic acid tert-butyl ester Suppliers

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1093759-59-1