1-Boc-3-azetidineacetic acid ethyl ester
- Product Name
- 1-Boc-3-azetidineacetic acid ethyl ester
- CAS No.
- 158602-35-8
- Chemical Name
- 1-Boc-3-azetidineacetic acid ethyl ester
- Synonyms
- 3-(2-Ethoxy;Ethyl 1-Boc-3-azetidineacetate;tert-Butyl 3-(2-ethoxy-2-oxoethyl);1-Boc-3-(2-ethoxy-2-oxoethyl)azetidine;1-Boc-3-azetidineacetic acid ethyl ester;Ethyl 1-Boc-3-azetidineacetate - [E11853];Ethyl 1-(tert-Butoxycarbonyl)-3-azetidineacetate;1-(tert-Butoxycarbonyl)-3-(2-ethoxy-2-oxoethyl)azetidine;1-(tert-Butoxycarbonyl)-3-azetidineacetic Acid Ethyl Ester;3-Ethoxycarbonylmethyl-azetidine-1-carboxylic acid tert-butyl ester
- CBNumber
- CB22619347
- Molecular Formula
- C12H21NO4
- Formula Weight
- 243.3
- MOL File
- 158602-35-8.mol
1-Boc-3-azetidineacetic acid ethyl ester Property
- Boiling point:
- 303.0±15.0 °C(Predicted)
- Density
- 1.089±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- clear liquid
- pka
- -1.89±0.40(Predicted)
- color
- Colorless to Light yellow
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E1390
- Product name
- Ethyl 1-(tert-Butoxycarbonyl)-3-azetidineacetate
- Packaging
- 1G
- Price
- $122
- Updated
- 2025/07/31
- Product number
- T135700
- Product name
- tert-Butyl3-(2-Ethoxy-2-oxoethyl)azetidine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H58-1-B9
- Product name
- Ethyl 1-Boc-3-azetidineacetate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 42572
- Product name
- Ethyl1-(tert-butoxycarbonyl)-3-azetidineacetate,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 1G
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 8083CV
- Product name
- Tert-butyl3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
1-Boc-3-azetidineacetic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
183062-96-6
158602-35-8
a) Synthesis of 1-[2-(ethoxy)-2-oxoethyl]-1-azetidinecarboxylic acid 1,1-dimethylethyl ester To an oven-dried 250 mL round-bottomed flask under nitrogen protection was added a solution of 1-{[(1,1-dimethylethyl)oxy]carbonyl}-3-azetidinyl)acetic acid (10 g, 46.5 mmol) in ether (100 mL). N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (9.80 g, 51.1 mmol), 4-(dimethylamino)pyridine (0.568 g, 4.65 mmol), and ethanol (5.97 mL, 102 mmol) were then added sequentially. The reaction mixture was stirred at room temperature overnight. After 1 hour of reaction, the white mixture was transformed into a colorless solution and a gelatinous substance was visible at the bottom of the bottle. The reaction mixture was diluted with ether (300 mL) and washed sequentially with 1M NaHSO4 aqueous solution (150 mL) and saturated NaHCO3 aqueous solution (150 mL). The organic phase was separated, dried over MgSO4 and concentrated under reduced pressure to give tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate (10.55 g, 93% yield) as a clear, colorless liquid.MS (ES)+ m/e 244.4 [M + H]+.
References
[1] Patent: WO2011/103546, 2011, A1. Location in patent: Page/Page column 105-106
1-Boc-3-azetidineacetic acid ethyl ester Preparation Products And Raw materials
Raw materials
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