1-Boc-3-azetidineacetic acid ethyl ester

1-Boc-3-azetidineacetic acid ethyl ester Property

Boiling point:

303.0±15.0 °C(Predicted)

Density 

1.089±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

clear liquid

pka

-1.89±0.40(Predicted)

color 

Colorless to Light yellow

Safety

HS Code 

2933998090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

1-Boc-3-azetidineacetic acid ethyl ester Chemical Properties,Usage,Production

Synthesis

a) Synthesis of 1-[2-(ethoxy)-2-oxoethyl]-1-azetidinecarboxylic acid 1,1-dimethylethyl ester To an oven-dried 250 mL round-bottomed flask under nitrogen protection was added a solution of 1-{[(1,1-dimethylethyl)oxy]carbonyl}-3-azetidinyl)acetic acid (10 g, 46.5 mmol) in ether (100 mL). N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (9.80 g, 51.1 mmol), 4-(dimethylamino)pyridine (0.568 g, 4.65 mmol), and ethanol (5.97 mL, 102 mmol) were then added sequentially. The reaction mixture was stirred at room temperature overnight. After 1 hour of reaction, the white mixture was transformed into a colorless solution and a gelatinous substance was visible at the bottom of the bottle. The reaction mixture was diluted with ether (300 mL) and washed sequentially with 1M NaHSO4 aqueous solution (150 mL) and saturated NaHCO3 aqueous solution (150 mL). The organic phase was separated, dried over MgSO4 and concentrated under reduced pressure to give tert-butyl 3-(2-ethoxy-2-oxoethyl)azetidine-1-carboxylate (10.55 g, 93% yield) as a clear, colorless liquid.MS (ES)+ m/e 244.4 [M + H]+.

References

[1] Patent: WO2011/103546, 2011, A1. Location in patent: Page/Page column 105-106